Predictors of Daily Adherence to HIV Pre-exposure Prophylaxis in Gay/Bisexual Men in the PRELUDE Demonstration Project View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-06

AUTHORS

Stefanie J. Vaccher, Mark A. Marzinke, David J. Templeton, Bridget G. Haire, Nathan Ryder, Anna McNulty, Rosalind Foster, Andrew E. Grulich, Iryna B. Zablotska, the PRELUDE Study Team, the NSW HIV Prevention Partnership Project

ABSTRACT

Adequate adherence to pre-exposure prophylaxis (PrEP) is critical to prevent HIV infection, but accurately measuring adherence remains challenging. We compared two biological [blood drug concentrations in plasma and peripheral blood mononuclear cells (PBMC)] and two self-reported measures (facilitated recall to clinicians and self-report in online surveys) and identified predictors of daily PrEP adherence among gay and bisexual men (GBM) in their first 12 months on PRELUDE, an open-label, single-arm PrEP demonstration project in New South Wales, Australia. 327 participants were enrolled; 263 GBM attended their 12-month follow-up visit (81% retention). Overall, 91% of blood samples had plasma drug concentrations indicative of taking 7 pills/week, and 99% had protective drug concentrations (≥ 4 pills/week). Facilitated recall to clinicians identified 99% of participants with protective adherence as measured by PBMC drug concentrations. Daily adherence measured by facilitated recall was associated with behavioural practices including group sex (aOR 1.33, 95% CI 1.15-1.53, p < 0.001). Retained participants maintained high adherence to daily PrEP over 12 months, confirmed by four different measures. Facilitated recall to clinicians is a suitable measure for assessing PrEP adherence in populations engaged in care where there is established trust and rapport with patients. Trial registration: ClinicalTrials.gov NCT02206555. More... »

PAGES

1-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10461-018-2353-5

DOI

http://dx.doi.org/10.1007/s10461-018-2353-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110421790

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30523489


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