Baseline Cigarette Smoking Status as a Predictor of Virologic Suppression and CD4 Cell Count During One-Year Follow-Up in Substance Users ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Theresa Winhusen, Daniel J. Feaster, Rui Duan, Jennifer L. Brown, Eric S. Daar, Raul Mandler, Lisa R. Metsch

ABSTRACT

Cigarette smoking is prevalent in people living with HIV/AIDS (PLHIV) who abuse alcohol and/or illicit substances. This study evaluated whether smoking is predictive of virologic non-suppression (> 200 copies/mL) and low CD4 count (< 200 cells/mm3) during 1-year follow-up in medically hospitalized, substance-using PLHIV recruited for a multi-site trial. Smoking status was assessed with the Heaviness of Smoking Index (HSI). Analyses revealed that, controlling for baseline differences and adherence to antiretroviral therapy, non-smokers (n = 237), compared to smokers scoring in the medium-to-high range on the HSI (n = 386), were significantly more likely to achieve viral suppression (OR 1.50, 95% CI 1.02, 2.20). There was a significant smoking-by-time interaction for CD4 cell count (χ2(1) = 4.08, p < .05), with smokers less likely to have low CD4 count at baseline and 6-month follow-up, but more likely to have low CD4 count at 12-month follow-up. The results suggest that smoking may play a role in immunological functioning in HIV-infected substance users. ClinicalTrials.gov Identifier: NCT01612169. More... »

PAGES

2026-2032

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10461-017-1928-x

DOI

http://dx.doi.org/10.1007/s10461-017-1928-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092198862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29030717


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