Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05

AUTHORS

Teele Kuusk, Laurence Albiges, Bernard Escudier, Nikolaos Grivas, John Haanen, Thomas Powles, Axel Bex

ABSTRACT

Antiangiogenic therapy with vascular endothelial growth factor (VEGF) inhibitors is the current first-line treatment in metastatic renal cell carcinoma (mRCC). Immunotherapy with checkpoint inhibitor has been recently added to the armamentarium of mRCC treatment. These therapies are based on treatment with antibodies that block programmed cell death-1 (PD-1), programmed cell death ligand 1 (PD-L1) pathways, demonstrating impressive response rates and improved survival in several tumour types. So far, nivolumab is the only approved anti-PD-1 monoclonal antibody after VEGF therapy in mRCC. According to preclinical and clinical studies, combination therapies with VEGF- and checkpoint inhibitors have synergistic effect achieving improved response rates. However, toxicity in some combinations is high. In this article, we present a review of the ongoing trials with these drug combinations for RCC. More... »

PAGES

205-215

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10456-017-9550-0

DOI

http://dx.doi.org/10.1007/s10456-017-9550-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084753299

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28401381


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