miRNAs: micro-managers of anticancer combination therapies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05

AUTHORS

Judy R. van Beijnum, Elisa Giovannetti, Dennis Poel, Patrycja Nowak-Sliwinska, Arjan W. Griffioen

ABSTRACT

Angiogenesis is one of the hallmarks of cancer progression and as such has been considered a target of therapeutic interest. However, single targeted agents have not fully lived up to the initial promise of anti-angiogenic therapy. Therefore, it has been suggested that combining therapies and agents will be the way forward in the oncology field. In recent years, microRNAs (miRNAs) have received considerable attention as drivers of tumor development and progression, either acting as tumor suppressors or as oncogenes (so-called oncomiRs), as well as in the process of tumor angiogenesis (angiomiRs). Not only from a functional, but also from a therapeutic view, miRNAs are attractive tools. Thus far, several mimics and antagonists of miRNAs have entered clinical development. Here, we review the provenance and promise of miRNAs as targets as well as therapeutics to contribute to anti-angiogenesis-based (combination) treatment of cancer. More... »

PAGES

269-285

References to SciGraph publications

  • 2014-07. Downregulation of miR-221/222 enhances sensitivity of breast cancer cells to tamoxifen through upregulation of TIMP3 in CANCER GENE THERAPY
  • 2017-03. Overcoming cellular barriers for RNA therapeutics in NATURE BIOTECHNOLOGY
  • 2017-05. Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy? in ANGIOGENESIS
  • 2017-05. Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment in ANGIOGENESIS
  • 2017-05. The clinical application of angiostatic therapy in combination with radiotherapy: past, present, future in ANGIOGENESIS
  • 2016-09. Small molecule-mediated up-regulation of microRNA targeting a key cell death modulator BNIP3 improves cardiac function following ischemic injury in SCIENTIFIC REPORTS
  • 2016-12. Role of Mir-155 in Controlling HIF-1α Level and Promoting Endothelial Cell Maturation in SCIENTIFIC REPORTS
  • 2012-12. DNA repair dysregulation from cancer driver to therapeutic target in NATURE REVIEWS CANCER
  • 2011-05. Molecular mechanisms and clinical applications of angiogenesis in NATURE
  • 2016-10. Up- regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy in SCIENTIFIC REPORTS
  • 2015-02. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment in NATURE
  • 2017-04. Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors in INVESTIGATIONAL NEW DRUGS
  • 2016-04-04. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer in NATURE COMMUNICATIONS
  • 2012-01. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells in NATURE
  • 2012-11. miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2017-05. Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer in ANGIOGENESIS
  • 2014-12. MicroRNA-34a functions as an anti-metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44 in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2013-06. Decrease in blood miR-296 predicts chemotherapy resistance and poor clinical outcome in patients receiving systemic chemotherapy for metastatic colon cancer in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2016-04. Knockdown of miR-221 promotes the cisplatin-inducing apoptosis by targeting the BIM-Bax/Bak axis in breast cancer in TUMOR BIOLOGY
  • 2010-12. Vascular regrowth following photodynamic therapy in the chicken embryo chorioallantoic membrane in ANGIOGENESIS
  • 2011-04. Strategies to improve radiotherapy with targeted drugs in NATURE REVIEWS CANCER
  • 2017-03. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases in NATURE REVIEWS DRUG DISCOVERY
  • 2017. Identification of Small Molecule Modulators of MicroRNA by Library Screening in DRUG TARGET MIRNA
  • 2010-04. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis in NATURE
  • 2013-11. MicroRNAs and other non-coding RNAs as targets for anticancer drug development in NATURE REVIEWS DRUG DISCOVERY
  • 2015-12. The regulatory and predictive functions of miR-17 and miR-92 families on cisplatin resistance of non-small cell lung cancer in BMC CANCER
  • 2016-02. Optimization of drug combinations using Feedback System Control in NATURE PROTOCOLS
  • 2015-07. Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer in ANGIOGENESIS
  • 2013-03. MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines in CELL DEATH & DISEASE
  • 1993-10. Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix in BRITISH JOURNAL OF CANCER
  • 2015-04. Tissue inhibitor of metalloproteinase-3 (TIMP3) promotes endothelial apoptosis via a caspase-independent mechanism in APOPTOSIS
  • 2007-04. miR-21-mediated tumor growth in ONCOGENE
  • 2013-12. Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice in RADIATION ONCOLOGY
  • 2014-02. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer in ONCOGENE
  • 2011-11. Tumor angiogenesis: molecular pathways and therapeutic targets in NATURE MEDICINE
  • 2014-10. The chicken chorioallantoic membrane model in biology, medicine and bioengineering in ANGIOGENESIS
  • 2010-08. MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis in NATURE MEDICINE
  • 2010-03. Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? in ANGIOGENESIS
  • 2015-06. Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma in CELL BIOCHEMISTRY AND BIOPHYSICS
  • 2014-08. Therapeutic targeting of microRNAs: current status and future challenges in NATURE REVIEWS DRUG DISCOVERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10456-017-9545-x

    DOI

    http://dx.doi.org/10.1007/s10456-017-9545-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085132829

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28474282


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Pathologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Neoplasm", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Angiogenesis Laboratory, Department of Medical Oncology, VUMC - Cancer Center Amsterdam, VU University Medical Center (VUmc), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Beijnum", 
            "givenName": "Judy R.", 
            "id": "sg:person.01357350151.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357350151.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Laboratory Medical Oncology, Department of Medical Oncology, VUMC - Cancer Center Amsterdam, VU University Medical Center (VUmc), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giovannetti", 
            "givenName": "Elisa", 
            "id": "sg:person.0577505063.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577505063.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Angiogenesis Laboratory, Department of Medical Oncology, VUMC - Cancer Center Amsterdam, VU University Medical Center (VUmc), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poel", 
            "givenName": "Dennis", 
            "id": "sg:person.0647341305.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647341305.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Geneva", 
              "id": "https://www.grid.ac/institutes/grid.8591.5", 
              "name": [
                "School of Pharmaceutical Sciences, University of Geneva (UNIGE), Geneva, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nowak-Sliwinska", 
            "givenName": "Patrycja", 
            "id": "sg:person.01150324555.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150324555.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Angiogenesis Laboratory, Department of Medical Oncology, VUMC - Cancer Center Amsterdam, VU University Medical Center (VUmc), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Griffioen", 
            "givenName": "Arjan W.", 
            "id": "sg:person.0750735571.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750735571.78"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-1755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000370007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000990475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2013.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001934432", 
              "https://doi.org/10.1038/cddis.2013.71"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2007.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004300736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005358522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/epi-2016-0035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005368235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005425145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-2441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005499390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2013.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005790895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.2235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005811784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep31651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006257549", 
              "https://doi.org/10.1038/srep31651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007187065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2011.01440.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007230470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007355288", 
              "https://doi.org/10.1038/onc.2012.636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007355288", 
              "https://doi.org/10.1038/onc.2012.636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2008.04.045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007403975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007690825", 
              "https://doi.org/10.1038/nrc3007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nou084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008104020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/jca.10765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008639684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2014.79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009500801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2009.06.075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009781497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010208236", 
              "https://doi.org/10.1038/nature10661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cge.12362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010398329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-015-4267-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010612182", 
              "https://doi.org/10.1007/s13277-015-4267-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2014.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011095642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.200801555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011449310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mtm.2014.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011470275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011625732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2014.05.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011962111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-6563-2_12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012689816", 
              "https://doi.org/10.1007/978-1-4939-6563-2_12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa031317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012809616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cgt.2014.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013497473", 
              "https://doi.org/10.1038/cgt.2014.29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cgt.2014.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013497473", 
              "https://doi.org/10.1038/cgt.2014.29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013864378", 
              "https://doi.org/10.1038/nm.2186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2008.12.098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014077364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2015.129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014712013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015345471", 
              "https://doi.org/10.1038/nrc3399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2009.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015410118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbio.200900082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016145572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbio.200900082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016145572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10495-014-1076-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016146217", 
              "https://doi.org/10.1007/s10495-014-1076-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2005.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016798455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2005.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016798455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a006643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017182272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.9264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017194068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018253962", 
              "https://doi.org/10.1038/nrd4140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2015.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018314073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/941980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018382641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2211068216682338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019113133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2211068216682338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019113133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.10887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019343657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2016.08.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019994831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2012.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020042737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020160181", 
              "https://doi.org/10.1038/sj.onc.1210083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020160181", 
              "https://doi.org/10.1038/sj.onc.1210083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020448006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drup.2012.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020788254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-02-004291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021318753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.12734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021836554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0019139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022308253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-010-9185-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022545843", 
              "https://doi.org/10.1007/s10456-010-9185-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.12.7878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022697035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001622-200401000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023028909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001622-200401000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023028909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.5037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023199834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep35316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023335584", 
              "https://doi.org/10.1038/srep35316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2012.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023835661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023956879", 
              "https://doi.org/10.1038/nrd4359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2010.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024764595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024946989", 
              "https://doi.org/10.1038/nature08889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024946989", 
              "https://doi.org/10.1038/nature08889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/ijn.s64456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024951086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2014.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025102965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-012-1560-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025383287", 
              "https://doi.org/10.1007/s00384-012-1560-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.12.10.17681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027400992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1572-1000(04)00007-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027401788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0086263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027556679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01395-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027701800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0055652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028461610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-07-0573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029310583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m800731200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029400347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2009.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030173606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-016-0407-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443771", 
              "https://doi.org/10.1007/s10637-016-0407-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-016-0407-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443771", 
              "https://doi.org/10.1007/s10637-016-0407-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/878450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030626171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jphotobiol.2013.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030751942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1402604111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030840953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-012-1396-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030865090", 
              "https://doi.org/10.1007/s11010-012-1396-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031152422", 
              "https://doi.org/10.1038/nm.2537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-01-012369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031346338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2014.03.105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031757966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0078344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031771634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.9237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031801877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.158790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032172947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1523975113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032225283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.22126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032236463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.22126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032236463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drup.2016.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032368900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.2623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032540268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/pr.114.010215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032697481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drup.2007.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032888455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.2012.1632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032941572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12013-014-0501-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033257508", 
              "https://doi.org/10.1007/s12013-014-0501-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-1667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033663023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2012.11.133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034335940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.7005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034428566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.12814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034596347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2012.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034697430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034725932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cas.12370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035614386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-0365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035780356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199202203260805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036045418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1308345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036201464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0b013e328345a180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036217296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0b013e328345a180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036217296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000265065.26744.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036694006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000265065.26744.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036694006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/abbs/gms026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036911491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e3181ba82e1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037513904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e3181ba82e1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037513904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e3181ba82e1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037513904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep23472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038527150", 
              "https://doi.org/10.1038/srep23472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2016.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038974742", 
              "https://doi.org/10.1038/nprot.2016.017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.115.226894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039081993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039350775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci.insight.86051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039681808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci.insight.86051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039681808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039740519", 
              "https://doi.org/10.1038/nature13905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.4769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040031267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-009-9160-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040167422", 
              "https://doi.org/10.1007/s10456-009-9160-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-009-9160-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040167422", 
              "https://doi.org/10.1007/s10456-009-9160-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja505986a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040895801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/dds496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040916501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13046-014-0115-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040981247", 
              "https://doi.org/10.1186/s13046-014-0115-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13046-014-0115-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040981247", 
              "https://doi.org/10.1186/s13046-014-0115-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-014-9440-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041430693", 
              "https://doi.org/10.1007/s10456-014-9440-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0781.2010.00507.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041446865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0781.2010.00507.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041446865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mtna.2015.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041492583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.5495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041657598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0113050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043074165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopha.2015.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043117212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2015.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043907812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.029736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044913248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0907904107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045318191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2009.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045351527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-16-0096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045483260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201100899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045530046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2014.06.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046272686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046416991", 
              "https://doi.org/10.1038/ncomms11169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1751-1097.2009.00684.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047303543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1751-1097.2009.00684.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047303543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0603883103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048923044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2472630316682338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049174573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2472630316682338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049174573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-015-9462-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049455180", 
              "https://doi.org/10.1007/s10456-015-9462-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-015-9462-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049455180", 
              "https://doi.org/10.1007/s10456-015-9462-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-14-0855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050117337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050798018", 
              "https://doi.org/10.1038/nature10144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-0002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051120913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1748-717x-8-102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052279234", 
              "https://doi.org/10.1186/1748-717x-8-102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1713-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052644995", 
              "https://doi.org/10.1186/s12885-015-1713-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1993.434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052902752", 
              "https://doi.org/10.1038/bjc.1993.434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1993.434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052902752", 
              "https://doi.org/10.1038/bjc.1993.434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp100315q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056212458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp100315q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056212458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20140193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056717752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20140193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056717752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1104819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062451171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/092986711795843272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069162123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1389557515666150324123208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069183893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2015.4436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071523281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2015.4436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071523281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2016.4400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071527172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2016.4400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071527172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.2011.1535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071531648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.2014.3012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071532915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.2014.3012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071532915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cam.3.2.7910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072291921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7785/tcrt.2012.500364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074053007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7785/tcrt.2012.500364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074053007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074647481", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1568026617666161116144744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079355356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/2211536605666161208154633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079365284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd.2016.246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083845449", 
              "https://doi.org/10.1038/nrd.2016.246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9546-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084024660", 
              "https://doi.org/10.1007/s10456-017-9546-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9546-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084024660", 
              "https://doi.org/10.1007/s10456-017-9546-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9552-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084024661", 
              "https://doi.org/10.1007/s10456-017-9552-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9552-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084024661", 
              "https://doi.org/10.1007/s10456-017-9552-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128640", 
              "https://doi.org/10.1038/nbt.3802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9551-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084513520", 
              "https://doi.org/10.1007/s10456-017-9551-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9551-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084513520", 
              "https://doi.org/10.1007/s10456-017-9551-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9550-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084753299", 
              "https://doi.org/10.1007/s10456-017-9550-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-017-9550-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084753299", 
              "https://doi.org/10.1007/s10456-017-9550-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05", 
        "datePublishedReg": "2017-05-01", 
        "description": "Angiogenesis is one of the hallmarks of cancer progression and as such has been considered a target of therapeutic interest. However, single targeted agents have not fully lived up to the initial promise of anti-angiogenic therapy. Therefore, it has been suggested that combining therapies and agents will be the way forward in the oncology field. In recent years, microRNAs (miRNAs) have received considerable attention as drivers of tumor development and progression, either acting as tumor suppressors or as oncogenes (so-called oncomiRs), as well as in the process of tumor angiogenesis (angiomiRs). Not only from a functional, but also from a therapeutic view, miRNAs are attractive tools. Thus far, several mimics and antagonists of miRNAs have entered clinical development. Here, we review the provenance and promise of miRNAs as targets as well as therapeutics to contribute to anti-angiogenesis-based (combination) treatment of cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10456-017-9545-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1119026", 
            "issn": [
              "0969-6970", 
              "1573-7209"
            ], 
            "name": "Angiogenesis", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "miRNAs: micro-managers of anticancer combination therapies", 
        "pagination": "269-285", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4bf0b09048d5e8d2def78b88401643f2bf40b0dcb4d3ea08b1b3f1f5d32b7889"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28474282"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9814575"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10456-017-9545-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085132829"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10456-017-9545-x", 
          "https://app.dimensions.ai/details/publication/pub.1085132829"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29203_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs10456-017-9545-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10456-017-9545-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10456-017-9545-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10456-017-9545-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10456-017-9545-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    657 TRIPLES      21 PREDICATES      199 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10456-017-9545-x schema:about N20a978c616544aedb455d35922ef6afe
    2 N497de24637fb490d9868c14b2f5a563b
    3 N4f40f3da2a464bc18846236503122aab
    4 N6e80e1a791f141269197b35e8073b2ad
    5 N7161093f5f9a48fbad0e4b49dc044f8d
    6 N8bd535a52dc547f9ae840e34b1a7df90
    7 Na406e807917c41e291b960fad9c57321
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author N9d57f67e3f024bf3a3f6b8273dc9f53c
    11 schema:citation sg:pub.10.1007/978-1-4939-6563-2_12
    12 sg:pub.10.1007/s00384-012-1560-1
    13 sg:pub.10.1007/s10456-009-9160-6
    14 sg:pub.10.1007/s10456-010-9185-x
    15 sg:pub.10.1007/s10456-014-9440-7
    16 sg:pub.10.1007/s10456-015-9462-9
    17 sg:pub.10.1007/s10456-017-9546-9
    18 sg:pub.10.1007/s10456-017-9550-0
    19 sg:pub.10.1007/s10456-017-9551-z
    20 sg:pub.10.1007/s10456-017-9552-y
    21 sg:pub.10.1007/s10495-014-1076-y
    22 sg:pub.10.1007/s10637-016-0407-y
    23 sg:pub.10.1007/s11010-012-1396-6
    24 sg:pub.10.1007/s12013-014-0501-8
    25 sg:pub.10.1007/s13277-015-4267-4
    26 sg:pub.10.1038/bjc.1993.434
    27 sg:pub.10.1038/cddis.2013.71
    28 sg:pub.10.1038/cgt.2014.29
    29 sg:pub.10.1038/nature08889
    30 sg:pub.10.1038/nature10144
    31 sg:pub.10.1038/nature10661
    32 sg:pub.10.1038/nature13905
    33 sg:pub.10.1038/nbt.3802
    34 sg:pub.10.1038/ncomms11169
    35 sg:pub.10.1038/nm.2186
    36 sg:pub.10.1038/nm.2537
    37 sg:pub.10.1038/nprot.2016.017
    38 sg:pub.10.1038/nrc3007
    39 sg:pub.10.1038/nrc3399
    40 sg:pub.10.1038/nrd.2016.246
    41 sg:pub.10.1038/nrd4140
    42 sg:pub.10.1038/nrd4359
    43 sg:pub.10.1038/onc.2012.636
    44 sg:pub.10.1038/sj.onc.1210083
    45 sg:pub.10.1038/srep23472
    46 sg:pub.10.1038/srep31651
    47 sg:pub.10.1038/srep35316
    48 sg:pub.10.1186/1748-717x-8-102
    49 sg:pub.10.1186/s12885-015-1713-z
    50 sg:pub.10.1186/s13046-014-0115-4
    51 https://app.dimensions.ai/details/publication/pub.1074647481
    52 https://doi.org/10.1002/anie.200801555
    53 https://doi.org/10.1002/jbio.200900082
    54 https://doi.org/10.1002/jcp.22126
    55 https://doi.org/10.1002/jgm.2623
    56 https://doi.org/10.1016/j.addr.2014.09.010
    57 https://doi.org/10.1016/j.bbcan.2005.06.001
    58 https://doi.org/10.1016/j.bbcan.2009.09.005
    59 https://doi.org/10.1016/j.bbcan.2012.03.003
    60 https://doi.org/10.1016/j.bbcan.2012.10.004
    61 https://doi.org/10.1016/j.bbrc.2008.12.098
    62 https://doi.org/10.1016/j.bbrc.2009.02.013
    63 https://doi.org/10.1016/j.bbrc.2009.06.075
    64 https://doi.org/10.1016/j.bbrc.2014.03.105
    65 https://doi.org/10.1016/j.bcp.2015.10.015
    66 https://doi.org/10.1016/j.biopha.2015.12.002
    67 https://doi.org/10.1016/j.brainres.2010.07.009
    68 https://doi.org/10.1016/j.canlet.2008.04.045
    69 https://doi.org/10.1016/j.canlet.2016.08.009
    70 https://doi.org/10.1016/j.ccr.2008.10.005
    71 https://doi.org/10.1016/j.cell.2011.02.013
    72 https://doi.org/10.1016/j.devcel.2008.07.002
    73 https://doi.org/10.1016/j.devcel.2008.07.008
    74 https://doi.org/10.1016/j.drup.2007.02.002
    75 https://doi.org/10.1016/j.drup.2012.04.002
    76 https://doi.org/10.1016/j.drup.2016.02.002
    77 https://doi.org/10.1016/j.gde.2009.04.002
    78 https://doi.org/10.1016/j.ijpharm.2014.06.028
    79 https://doi.org/10.1016/j.jconrel.2014.09.001
    80 https://doi.org/10.1016/j.jconrel.2015.04.002
    81 https://doi.org/10.1016/j.jphotobiol.2013.01.012
    82 https://doi.org/10.1016/j.juro.2012.11.133
    83 https://doi.org/10.1016/j.tips.2007.10.014
    84 https://doi.org/10.1016/j.yexcr.2012.02.010
    85 https://doi.org/10.1016/j.yexcr.2014.05.022
    86 https://doi.org/10.1016/s1572-1000(04)00007-9
    87 https://doi.org/10.1021/ja505986a
    88 https://doi.org/10.1021/mp100315q
    89 https://doi.org/10.1038/mt.2014.79
    90 https://doi.org/10.1038/mt.2015.129
    91 https://doi.org/10.1038/mtm.2014.64
    92 https://doi.org/10.1038/mtna.2015.47
    93 https://doi.org/10.1042/bst20140193
    94 https://doi.org/10.1053/j.gastro.2013.10.010
    95 https://doi.org/10.1056/nejm199202203260805
    96 https://doi.org/10.1056/nejmoa031317
    97 https://doi.org/10.1056/nejmoa1308345
    98 https://doi.org/10.1073/pnas.0603883103
    99 https://doi.org/10.1073/pnas.0907904107
    100 https://doi.org/10.1073/pnas.1402604111
    101 https://doi.org/10.1073/pnas.1523975113
    102 https://doi.org/10.1074/jbc.m110.158790
    103 https://doi.org/10.1074/jbc.m800731200
    104 https://doi.org/10.1093/abbs/gms026
    105 https://doi.org/10.1093/hmg/dds496
    106 https://doi.org/10.1093/neuonc/nou084
    107 https://doi.org/10.1097/00001622-200401000-00009
    108 https://doi.org/10.1097/moh.0b013e328345a180
    109 https://doi.org/10.1097/mpa.0b013e3181ba82e1
    110 https://doi.org/10.1101/cshperspect.a006643
    111 https://doi.org/10.1111/cas.12370
    112 https://doi.org/10.1111/cge.12362
    113 https://doi.org/10.1111/j.1582-4934.2011.01440.x
    114 https://doi.org/10.1111/j.1600-0781.2010.00507.x
    115 https://doi.org/10.1111/j.1751-1097.2009.00684.x
    116 https://doi.org/10.1124/jpet.115.226894
    117 https://doi.org/10.1124/pr.114.010215
    118 https://doi.org/10.1126/science.1104819
    119 https://doi.org/10.1128/mcb.01395-06
    120 https://doi.org/10.1155/2014/878450
    121 https://doi.org/10.1155/2015/941980
    122 https://doi.org/10.1158/0008-5472.can-10-2010
    123 https://doi.org/10.1158/0008-5472.can-11-0365
    124 https://doi.org/10.1158/0008-5472.can-14-0855
    125 https://doi.org/10.1158/1078-0432.ccr-06-2441
    126 https://doi.org/10.1158/1078-0432.ccr-07-1755
    127 https://doi.org/10.1158/1078-0432.ccr-11-0679
    128 https://doi.org/10.1158/1078-0432.ccr-11-1667
    129 https://doi.org/10.1158/1078-0432.ccr-12-0002
    130 https://doi.org/10.1158/1535-7163.mct-07-0573
    131 https://doi.org/10.1158/1535-7163.mct-16-0096
    132 https://doi.org/10.1161/01.res.0000265065.26744.17
    133 https://doi.org/10.1172/jci.insight.86051
    134 https://doi.org/10.1177/2211068216682338
    135 https://doi.org/10.1177/2472630316682338
    136 https://doi.org/10.1182/blood-2006-01-012369
    137 https://doi.org/10.1182/blood-2006-02-004291
    138 https://doi.org/10.1200/jco.2007.12.7878
    139 https://doi.org/10.1242/dev.029736
    140 https://doi.org/10.1371/journal.pone.0000116
    141 https://doi.org/10.1371/journal.pone.0010630
    142 https://doi.org/10.1371/journal.pone.0019139
    143 https://doi.org/10.1371/journal.pone.0055652
    144 https://doi.org/10.1371/journal.pone.0078344
    145 https://doi.org/10.1371/journal.pone.0086263
    146 https://doi.org/10.1371/journal.pone.0113050
    147 https://doi.org/10.15252/emmm.201100899
    148 https://doi.org/10.1593/neo.12734
    149 https://doi.org/10.18632/oncotarget.10887
    150 https://doi.org/10.18632/oncotarget.12814
    151 https://doi.org/10.18632/oncotarget.2235
    152 https://doi.org/10.18632/oncotarget.4769
    153 https://doi.org/10.18632/oncotarget.5037
    154 https://doi.org/10.18632/oncotarget.5495
    155 https://doi.org/10.18632/oncotarget.7005
    156 https://doi.org/10.18632/oncotarget.9237
    157 https://doi.org/10.18632/oncotarget.9264
    158 https://doi.org/10.2147/ijn.s64456
    159 https://doi.org/10.2174/092986711795843272
    160 https://doi.org/10.2174/1389557515666150324123208
    161 https://doi.org/10.2174/1568026617666161116144744
    162 https://doi.org/10.2174/2211536605666161208154633
    163 https://doi.org/10.2217/epi-2016-0035
    164 https://doi.org/10.3322/caac.20114
    165 https://doi.org/10.3892/mmr.2015.4436
    166 https://doi.org/10.3892/ol.2016.4400
    167 https://doi.org/10.3892/or.2011.1535
    168 https://doi.org/10.3892/or.2012.1632
    169 https://doi.org/10.3892/or.2014.3012
    170 https://doi.org/10.4161/cam.3.2.7910
    171 https://doi.org/10.4161/cbt.12.10.17681
    172 https://doi.org/10.7150/jca.10765
    173 https://doi.org/10.7785/tcrt.2012.500364
    174 schema:datePublished 2017-05
    175 schema:datePublishedReg 2017-05-01
    176 schema:description Angiogenesis is one of the hallmarks of cancer progression and as such has been considered a target of therapeutic interest. However, single targeted agents have not fully lived up to the initial promise of anti-angiogenic therapy. Therefore, it has been suggested that combining therapies and agents will be the way forward in the oncology field. In recent years, microRNAs (miRNAs) have received considerable attention as drivers of tumor development and progression, either acting as tumor suppressors or as oncogenes (so-called oncomiRs), as well as in the process of tumor angiogenesis (angiomiRs). Not only from a functional, but also from a therapeutic view, miRNAs are attractive tools. Thus far, several mimics and antagonists of miRNAs have entered clinical development. Here, we review the provenance and promise of miRNAs as targets as well as therapeutics to contribute to anti-angiogenesis-based (combination) treatment of cancer.
    177 schema:genre research_article
    178 schema:inLanguage en
    179 schema:isAccessibleForFree true
    180 schema:isPartOf N5e2055325b1a42df858499fe9fecf1ca
    181 Nfa00cbf05f06438db5e60a45fb9f446e
    182 sg:journal.1119026
    183 schema:name miRNAs: micro-managers of anticancer combination therapies
    184 schema:pagination 269-285
    185 schema:productId N344c29dfd7e44ac392331436c87d7567
    186 N9e55ae3c9ab847d7af9159c0552c8f65
    187 Nbcea4b84873a4b91a598da8a038e1821
    188 Nf7686ff8ec0f4a1094f7c35bcbf675ab
    189 Nf78e5ace0a9a47c388510938656bd980
    190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085132829
    191 https://doi.org/10.1007/s10456-017-9545-x
    192 schema:sdDatePublished 2019-04-11T11:54
    193 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    194 schema:sdPublisher Ne20ee960807b49e2ba23f7ac39123f98
    195 schema:url https://link.springer.com/10.1007%2Fs10456-017-9545-x
    196 sgo:license sg:explorer/license/
    197 sgo:sdDataset articles
    198 rdf:type schema:ScholarlyArticle
    199 N0840fb2363c34d559f01eff6b2d41c26 rdf:first sg:person.0577505063.56
    200 rdf:rest Nc2f2074245ca42029029aae505f33fea
    201 N20a978c616544aedb455d35922ef6afe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Neovascularization, Pathologic
    203 rdf:type schema:DefinedTerm
    204 N344c29dfd7e44ac392331436c87d7567 schema:name nlm_unique_id
    205 schema:value 9814575
    206 rdf:type schema:PropertyValue
    207 N497de24637fb490d9868c14b2f5a563b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Humans
    209 rdf:type schema:DefinedTerm
    210 N4f40f3da2a464bc18846236503122aab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name RNA, Neoplasm
    212 rdf:type schema:DefinedTerm
    213 N5e2055325b1a42df858499fe9fecf1ca schema:issueNumber 2
    214 rdf:type schema:PublicationIssue
    215 N5e62643b44e1468d9d957258f1e251ef rdf:first sg:person.0750735571.78
    216 rdf:rest rdf:nil
    217 N6e80e1a791f141269197b35e8073b2ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Animals
    219 rdf:type schema:DefinedTerm
    220 N7161093f5f9a48fbad0e4b49dc044f8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name MicroRNAs
    222 rdf:type schema:DefinedTerm
    223 N8bd535a52dc547f9ae840e34b1a7df90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Antineoplastic Combined Chemotherapy Protocols
    225 rdf:type schema:DefinedTerm
    226 N9d57f67e3f024bf3a3f6b8273dc9f53c rdf:first sg:person.01357350151.05
    227 rdf:rest N0840fb2363c34d559f01eff6b2d41c26
    228 N9e55ae3c9ab847d7af9159c0552c8f65 schema:name doi
    229 schema:value 10.1007/s10456-017-9545-x
    230 rdf:type schema:PropertyValue
    231 Na406e807917c41e291b960fad9c57321 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Neoplasms
    233 rdf:type schema:DefinedTerm
    234 Nbcea4b84873a4b91a598da8a038e1821 schema:name pubmed_id
    235 schema:value 28474282
    236 rdf:type schema:PropertyValue
    237 Nc2f2074245ca42029029aae505f33fea rdf:first sg:person.0647341305.28
    238 rdf:rest Nf344ce682e004f638bad2c34fe28a587
    239 Ne20ee960807b49e2ba23f7ac39123f98 schema:name Springer Nature - SN SciGraph project
    240 rdf:type schema:Organization
    241 Nf344ce682e004f638bad2c34fe28a587 rdf:first sg:person.01150324555.82
    242 rdf:rest N5e62643b44e1468d9d957258f1e251ef
    243 Nf7686ff8ec0f4a1094f7c35bcbf675ab schema:name readcube_id
    244 schema:value 4bf0b09048d5e8d2def78b88401643f2bf40b0dcb4d3ea08b1b3f1f5d32b7889
    245 rdf:type schema:PropertyValue
    246 Nf78e5ace0a9a47c388510938656bd980 schema:name dimensions_id
    247 schema:value pub.1085132829
    248 rdf:type schema:PropertyValue
    249 Nfa00cbf05f06438db5e60a45fb9f446e schema:volumeNumber 20
    250 rdf:type schema:PublicationVolume
    251 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    252 schema:name Medical and Health Sciences
    253 rdf:type schema:DefinedTerm
    254 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    255 schema:name Oncology and Carcinogenesis
    256 rdf:type schema:DefinedTerm
    257 sg:journal.1119026 schema:issn 0969-6970
    258 1573-7209
    259 schema:name Angiogenesis
    260 rdf:type schema:Periodical
    261 sg:person.01150324555.82 schema:affiliation https://www.grid.ac/institutes/grid.8591.5
    262 schema:familyName Nowak-Sliwinska
    263 schema:givenName Patrycja
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150324555.82
    265 rdf:type schema:Person
    266 sg:person.01357350151.05 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    267 schema:familyName van Beijnum
    268 schema:givenName Judy R.
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357350151.05
    270 rdf:type schema:Person
    271 sg:person.0577505063.56 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    272 schema:familyName Giovannetti
    273 schema:givenName Elisa
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577505063.56
    275 rdf:type schema:Person
    276 sg:person.0647341305.28 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    277 schema:familyName Poel
    278 schema:givenName Dennis
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647341305.28
    280 rdf:type schema:Person
    281 sg:person.0750735571.78 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    282 schema:familyName Griffioen
    283 schema:givenName Arjan W.
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750735571.78
    285 rdf:type schema:Person
    286 sg:pub.10.1007/978-1-4939-6563-2_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012689816
    287 https://doi.org/10.1007/978-1-4939-6563-2_12
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s00384-012-1560-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025383287
    290 https://doi.org/10.1007/s00384-012-1560-1
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s10456-009-9160-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040167422
    293 https://doi.org/10.1007/s10456-009-9160-6
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s10456-010-9185-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022545843
    296 https://doi.org/10.1007/s10456-010-9185-x
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s10456-014-9440-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041430693
    299 https://doi.org/10.1007/s10456-014-9440-7
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s10456-015-9462-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049455180
    302 https://doi.org/10.1007/s10456-015-9462-9
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s10456-017-9546-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084024660
    305 https://doi.org/10.1007/s10456-017-9546-9
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s10456-017-9550-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084753299
    308 https://doi.org/10.1007/s10456-017-9550-0
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s10456-017-9551-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1084513520
    311 https://doi.org/10.1007/s10456-017-9551-z
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s10456-017-9552-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084024661
    314 https://doi.org/10.1007/s10456-017-9552-y
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s10495-014-1076-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1016146217
    317 https://doi.org/10.1007/s10495-014-1076-y
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1007/s10637-016-0407-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443771
    320 https://doi.org/10.1007/s10637-016-0407-y
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1007/s11010-012-1396-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030865090
    323 https://doi.org/10.1007/s11010-012-1396-6
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1007/s12013-014-0501-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033257508
    326 https://doi.org/10.1007/s12013-014-0501-8
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1007/s13277-015-4267-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010612182
    329 https://doi.org/10.1007/s13277-015-4267-4
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/bjc.1993.434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052902752
    332 https://doi.org/10.1038/bjc.1993.434
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/cddis.2013.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001934432
    335 https://doi.org/10.1038/cddis.2013.71
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/cgt.2014.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013497473
    338 https://doi.org/10.1038/cgt.2014.29
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nature08889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024946989
    341 https://doi.org/10.1038/nature08889
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/nature10144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050798018
    344 https://doi.org/10.1038/nature10144
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nature10661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010208236
    347 https://doi.org/10.1038/nature10661
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/nature13905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039740519
    350 https://doi.org/10.1038/nature13905
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/nbt.3802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128640
    353 https://doi.org/10.1038/nbt.3802
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/ncomms11169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046416991
    356 https://doi.org/10.1038/ncomms11169
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/nm.2186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013864378
    359 https://doi.org/10.1038/nm.2186
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/nm.2537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031152422
    362 https://doi.org/10.1038/nm.2537
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/nprot.2016.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038974742
    365 https://doi.org/10.1038/nprot.2016.017
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/nrc3007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007690825
    368 https://doi.org/10.1038/nrc3007
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/nrc3399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015345471
    371 https://doi.org/10.1038/nrc3399
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/nrd.2016.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083845449
    374 https://doi.org/10.1038/nrd.2016.246
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/nrd4140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018253962
    377 https://doi.org/10.1038/nrd4140
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/nrd4359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023956879
    380 https://doi.org/10.1038/nrd4359
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/onc.2012.636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007355288
    383 https://doi.org/10.1038/onc.2012.636
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/sj.onc.1210083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020160181
    386 https://doi.org/10.1038/sj.onc.1210083
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/srep23472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038527150
    389 https://doi.org/10.1038/srep23472
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/srep31651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006257549
    392 https://doi.org/10.1038/srep31651
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/srep35316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023335584
    395 https://doi.org/10.1038/srep35316
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1186/1748-717x-8-102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052279234
    398 https://doi.org/10.1186/1748-717x-8-102
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1186/s12885-015-1713-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1052644995
    401 https://doi.org/10.1186/s12885-015-1713-z
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1186/s13046-014-0115-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040981247
    404 https://doi.org/10.1186/s13046-014-0115-4
    405 rdf:type schema:CreativeWork
    406 https://app.dimensions.ai/details/publication/pub.1074647481 schema:CreativeWork
    407 https://doi.org/10.1002/anie.200801555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011449310
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1002/jbio.200900082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016145572
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1002/jcp.22126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032236463
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1002/jgm.2623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032540268
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/j.addr.2014.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025102965
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.bbcan.2005.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016798455
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/j.bbcan.2009.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045351527
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/j.bbcan.2012.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020042737
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/j.bbcan.2012.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034697430
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/j.bbrc.2008.12.098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014077364
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/j.bbrc.2009.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030173606
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/j.bbrc.2009.06.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009781497
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/j.bbrc.2014.03.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031757966
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.bcp.2015.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043907812
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.biopha.2015.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043117212
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.brainres.2010.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024764595
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.canlet.2008.04.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007403975
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/j.canlet.2016.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019994831
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/j.ccr.2008.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039350775
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.devcel.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000990475
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/j.devcel.2008.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005425145
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/j.drup.2007.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032888455
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.drup.2012.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020788254
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.drup.2016.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032368900
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/j.gde.2009.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015410118
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/j.ijpharm.2014.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046272686
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/j.jconrel.2014.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011095642
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.jconrel.2015.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018314073
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.jphotobiol.2013.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030751942
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.juro.2012.11.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034335940
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.tips.2007.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004300736
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/j.yexcr.2012.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023835661
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/j.yexcr.2014.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011962111
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/s1572-1000(04)00007-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027401788
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1021/ja505986a schema:sameAs https://app.dimensions.ai/details/publication/pub.1040895801
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1021/mp100315q schema:sameAs https://app.dimensions.ai/details/publication/pub.1056212458
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1038/mt.2014.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009500801
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1038/mt.2015.129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014712013
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1038/mtm.2014.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011470275
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1038/mtna.2015.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041492583
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1042/bst20140193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717752
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1053/j.gastro.2013.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005790895
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1056/nejm199202203260805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036045418
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1056/nejmoa031317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012809616
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1056/nejmoa1308345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036201464
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1073/pnas.0603883103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048923044
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1073/pnas.0907904107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045318191
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1073/pnas.1402604111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030840953
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1073/pnas.1523975113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032225283
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1074/jbc.m110.158790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032172947
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1074/jbc.m800731200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029400347
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1093/abbs/gms026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036911491
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1093/hmg/dds496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040916501
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1093/neuonc/nou084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008104020
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1097/00001622-200401000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023028909
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1097/moh.0b013e328345a180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036217296
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1097/mpa.0b013e3181ba82e1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037513904
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1101/cshperspect.a006643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017182272
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1111/cas.12370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035614386
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1111/cge.12362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010398329
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1111/j.1582-4934.2011.01440.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007230470
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1111/j.1600-0781.2010.00507.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041446865
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1111/j.1751-1097.2009.00684.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047303543
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1124/jpet.115.226894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039081993
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1124/pr.114.010215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032697481
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1126/science.1104819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062451171
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1128/mcb.01395-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027701800
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1155/2014/878450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030626171
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1155/2015/941980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018382641
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1158/0008-5472.can-10-2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011625732
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1158/0008-5472.can-11-0365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035780356
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1158/0008-5472.can-14-0855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050117337
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1158/1078-0432.ccr-06-2441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005499390
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1158/1078-0432.ccr-07-1755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000370007
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1158/1078-0432.ccr-11-0679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034725932
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1158/1078-0432.ccr-11-1667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033663023
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1158/1078-0432.ccr-12-0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051120913
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1158/1535-7163.mct-07-0573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029310583
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1158/1535-7163.mct-16-0096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045483260
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1161/01.res.0000265065.26744.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036694006
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1172/jci.insight.86051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039681808
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1177/2211068216682338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019113133
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1177/2472630316682338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049174573
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1182/blood-2006-01-012369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031346338
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1182/blood-2006-02-004291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021318753
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1200/jco.2007.12.7878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022697035
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1242/dev.029736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044913248
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1371/journal.pone.0000116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007187065
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1371/journal.pone.0010630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005358522
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1371/journal.pone.0019139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022308253
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1371/journal.pone.0055652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028461610
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1371/journal.pone.0078344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031771634
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1371/journal.pone.0086263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027556679
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1371/journal.pone.0113050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043074165
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.15252/emmm.201100899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045530046
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1593/neo.12734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021836554
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.18632/oncotarget.10887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019343657
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.18632/oncotarget.12814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034596347
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.18632/oncotarget.2235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005811784
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.18632/oncotarget.4769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040031267
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.18632/oncotarget.5037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023199834
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.18632/oncotarget.5495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041657598
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.18632/oncotarget.7005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034428566
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.18632/oncotarget.9237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031801877
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.18632/oncotarget.9264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017194068
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.2147/ijn.s64456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024951086
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.2174/092986711795843272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069162123
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.2174/1389557515666150324123208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069183893
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.2174/1568026617666161116144744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079355356
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.2174/2211536605666161208154633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079365284
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.2217/epi-2016-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005368235
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.3322/caac.20114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020448006
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.3892/mmr.2015.4436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071523281
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.3892/ol.2016.4400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071527172
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.3892/or.2011.1535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071531648
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.3892/or.2012.1632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032941572
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.3892/or.2014.3012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071532915
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.4161/cam.3.2.7910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072291921
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.4161/cbt.12.10.17681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027400992
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.7150/jca.10765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008639684
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.7785/tcrt.2012.500364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074053007
    650 rdf:type schema:CreativeWork
    651 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    652 schema:name Angiogenesis Laboratory, Department of Medical Oncology, VUMC - Cancer Center Amsterdam, VU University Medical Center (VUmc), Amsterdam, The Netherlands
    653 Laboratory Medical Oncology, Department of Medical Oncology, VUMC - Cancer Center Amsterdam, VU University Medical Center (VUmc), Amsterdam, The Netherlands
    654 rdf:type schema:Organization
    655 https://www.grid.ac/institutes/grid.8591.5 schema:alternateName University of Geneva
    656 schema:name School of Pharmaceutical Sciences, University of Geneva (UNIGE), Geneva, Switzerland
    657 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...