Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08-07

AUTHORS

Serge Camelo, William Raoul, Sophie Lavalette, Bertrand Calippe, Brunella Cristofaro, Olivier Levy, Marianne Houssier, Eric Sulpice, Laurent Jonet, Christophe Klein, Estelle Devevre, Gilles Thuret, Antonio Duarte, Anne Eichmann, Laurence Leconte, Xavier Guillonneau, Florian Sennlaub

ABSTRACT

Inflammatory neovascularization, such as choroidal neovascularization (CNV), occur in the presence of Notch expressing macrophages. DLL4s anti-angiogenic effect on endothelial cells (EC) has been widely recognized, but its influence on Notch signaling on macrophages and its overall effect in inflammatory neovascularization is not well understood. We identified macrophages and ECs as the main Notch 1 and Notch 4 expressing cells in CNV. A soluble fraction spanning Ser28-Pro525 of the murine extracellular DLL4 domain (sDLL4/28-525) activated the Notch pathway, as it induces Notch target genes in macrophages and ECs and inhibited EC proliferation and vascular sprouting in aortic rings. In contrast, sDLL4/28-525 increased pro-angiogenic VEGF, and IL-1β expression in macrophages responsible for increased vascular sprouting observed in aortic rings incubated in conditioned media from sDLL4/28-525 stimulated macrophages. In vivo, Dll4(+/-) mice developed significantly more CNV and sDLL4/28-525 injections inhibited CNV in Dll4(+/-) CD1 mice. Similarly, sDLL4/28-525 inhibited CNV in C57Bl6 and its effect was reversed by a γ-secretase inhibitor that blocks Notch signaling. The inhibition occurred despite increased VEGF, IL-1β expression in infiltrating inflammatory macrophages in sDLL4/28-525 treated mice and might be due to direct inhibition of EC proliferation in laser-induced CNV as demonstrated by EdU labelling in vivo. In conclusion, Notch activation on macrophages and ECs leads to opposing effects in inflammatory neovascularization in situations such as CNV. More... »

PAGES

609-622

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10456-012-9290-0

DOI

http://dx.doi.org/10.1007/s10456-012-9290-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026685256

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22869002


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choroidal Neovascularization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages, Peritoneal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, UMR S 872, 75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "Centre de Recherche des Cordeliers, INSERM, UMR S 872, 75006 Paris, France", 
            "UPMC Univ Paris 06, UMR S 872, 75006 Paris, France", 
            "Universit\u00e9 Paris Descartes, UMR S 872, 75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Camelo", 
        "givenName": "Serge", 
        "id": "sg:person.01337534012.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337534012.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR_7210, 75012 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Inflammation, d\u00e9g\u00e9n\u00e9rescence et remodelage vasculaire dans les pathologies r\u00e9tiniennes\u00bb, Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France", 
            "Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France", 
            "CNRS, UMR_7210, 75012 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raoul", 
        "givenName": "William", 
        "id": "sg:person.01047304632.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047304632.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR_7210, 75012 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Inflammation, d\u00e9g\u00e9n\u00e9rescence et remodelage vasculaire dans les pathologies r\u00e9tiniennes\u00bb, Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France", 
            "Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France", 
            "CNRS, UMR_7210, 75012 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lavalette", 
        "givenName": "Sophie", 
        "id": "sg:person.0727671641.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727671641.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR_7210, 75012 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Inflammation, d\u00e9g\u00e9n\u00e9rescence et remodelage vasculaire dans les pathologies r\u00e9tiniennes\u00bb, Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France", 
            "Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France", 
            "CNRS, UMR_7210, 75012 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calippe", 
        "givenName": "Bertrand", 
        "id": "sg:person.01355754077.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355754077.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CIRB, Coll\u00e8ge de France, CNRS UMR 7241/Inserm U1050, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462887.7", 
          "name": [
            "CIRB, Coll\u00e8ge de France, CNRS UMR 7241/Inserm U1050, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cristofaro", 
        "givenName": "Brunella", 
        "id": "sg:person.0771260323.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771260323.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR_7210, 75012 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Inflammation, d\u00e9g\u00e9n\u00e9rescence et remodelage vasculaire dans les pathologies r\u00e9tiniennes\u00bb, Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France", 
            "Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France", 
            "CNRS, UMR_7210, 75012 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levy", 
        "givenName": "Olivier", 
        "id": "sg:person.01267244556.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267244556.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, UMR S 872, 75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "Centre de Recherche des Cordeliers, INSERM, UMR S 872, 75006 Paris, France", 
            "UPMC Univ Paris 06, UMR S 872, 75006 Paris, France", 
            "Universit\u00e9 Paris Descartes, UMR S 872, 75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houssier", 
        "givenName": "Marianne", 
        "id": "sg:person.01174402647.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174402647.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CEA Grenoble, DSV/iRTSV/BGE(INSERM U-1038)/Biomics, 17 rue des Martyrs, 38054 Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.457348.9", 
          "name": [
            "CEA Grenoble, DSV/iRTSV/BGE(INSERM U-1038)/Biomics, 17 rue des Martyrs, 38054 Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sulpice", 
        "givenName": "Eric", 
        "id": "sg:person.01130310301.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130310301.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, UMR S 872, 75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "Centre de Recherche des Cordeliers, INSERM, UMR S 872, 75006 Paris, France", 
            "UPMC Univ Paris 06, UMR S 872, 75006 Paris, France", 
            "Universit\u00e9 Paris Descartes, UMR S 872, 75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jonet", 
        "givenName": "Laurent", 
        "id": "sg:person.01052425027.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052425027.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Plateforme d\u2019imagerie, Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie, UMR S 872, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Plateforme d\u2019imagerie, Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie, UMR S 872, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein", 
        "givenName": "Christophe", 
        "id": "sg:person.011434217642.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011434217642.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Plateforme d\u2019imagerie, Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie, UMR S 872, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Plateforme d\u2019imagerie, Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie, UMR S 872, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Devevre", 
        "givenName": "Estelle", 
        "id": "sg:person.01173454717.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173454717.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique des H\u00f4pitaux de St Etienne, Centre hospitalier universitaire de Saint-Etienne, Universit\u00e9 Jean Monnet; Facult\u00e9 de M\u00e9decine, St Etienne, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Assistance Publique des H\u00f4pitaux de St Etienne, Centre hospitalier universitaire de Saint-Etienne, Universit\u00e9 Jean Monnet; Facult\u00e9 de M\u00e9decine, St Etienne, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thuret", 
        "givenName": "Gilles", 
        "id": "sg:person.01366453064.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366453064.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Gulbenkian de Ci\u00eancia, 2781-901 Oeiras, Portugal", 
          "id": "http://www.grid.ac/institutes/grid.418346.c", 
          "name": [
            "CIISA, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Avenida da Universidade T\u00e9cnica, 1300-477 Lisbon, Portugal", 
            "Instituto Gulbenkian de Ci\u00eancia, 2781-901 Oeiras, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duarte", 
        "givenName": "Antonio", 
        "id": "sg:person.0731014456.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731014456.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CIRB, Coll\u00e8ge de France, CNRS UMR 7241/Inserm U1050, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462887.7", 
          "name": [
            "CIRB, Coll\u00e8ge de France, CNRS UMR 7241/Inserm U1050, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eichmann", 
        "givenName": "Anne", 
        "id": "sg:person.01132655726.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132655726.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sis\u00e8ne; Paris Biotech Sant\u00e9, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.463770.1", 
          "name": [
            "Sis\u00e8ne; Paris Biotech Sant\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leconte", 
        "givenName": "Laurence", 
        "id": "sg:person.0716330041.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716330041.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR_7210, 75012 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Inflammation, d\u00e9g\u00e9n\u00e9rescence et remodelage vasculaire dans les pathologies r\u00e9tiniennes\u00bb, Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France", 
            "Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France", 
            "CNRS, UMR_7210, 75012 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guillonneau", 
        "givenName": "Xavier", 
        "id": "sg:person.0736717332.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736717332.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Equipe 14, Institut de la Vision, 17, rue Moreau, 75012 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.418241.a", 
          "name": [
            "Inflammation, d\u00e9g\u00e9n\u00e9rescence et remodelage vasculaire dans les pathologies r\u00e9tiniennes\u00bb, Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France", 
            "Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France", 
            "CNRS, UMR_7210, 75012 Paris, France", 
            "H\u00f4tel-Dieu Hospital, Department of Ophthalmology, APHP, Paris, France", 
            "Equipe 14, Institut de la Vision, 17, rue Moreau, 75012 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sennlaub", 
        "givenName": "Florian", 
        "id": "sg:person.01356263054.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature05355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037678066", 
          "https://doi.org/10.1038/nature05355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329630a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008055718", 
          "https://doi.org/10.1038/329630a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034553835", 
          "https://doi.org/10.1038/nature05313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01739641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027664151", 
          "https://doi.org/10.1007/bf01739641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007799896", 
          "https://doi.org/10.1038/nature08751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-7643-7311-3_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001296347", 
          "https://doi.org/10.1007/3-7643-7311-3_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00941723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021732396", 
          "https://doi.org/10.1007/bf00941723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35025220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043028620", 
          "https://doi.org/10.1038/35025220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029404187", 
          "https://doi.org/10.1038/nature10908"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-08-07", 
    "datePublishedReg": "2012-08-07", 
    "description": "Inflammatory neovascularization, such as choroidal neovascularization (CNV), occur in the presence of Notch expressing macrophages. DLL4s anti-angiogenic effect on endothelial cells (EC) has been widely recognized, but its influence on Notch signaling on macrophages and its overall effect in inflammatory neovascularization is not well understood. We identified macrophages and ECs as the main Notch 1 and Notch 4 expressing cells in CNV. A soluble fraction spanning Ser28-Pro525 of the murine extracellular DLL4 domain (sDLL4/28-525) activated the Notch pathway, as it induces Notch target genes in macrophages and ECs and inhibited EC proliferation and vascular sprouting in aortic rings. In contrast, sDLL4/28-525 increased pro-angiogenic VEGF, and IL-1\u03b2 expression in macrophages responsible for increased vascular sprouting observed in aortic rings incubated in conditioned media from sDLL4/28-525 stimulated macrophages. In vivo, Dll4(+/-) mice developed significantly more CNV and sDLL4/28-525 injections inhibited CNV in Dll4(+/-) CD1 mice. Similarly, sDLL4/28-525 inhibited CNV in C57Bl6 and its effect was reversed by a \u03b3-secretase inhibitor that blocks Notch signaling. The inhibition occurred despite increased VEGF, IL-1\u03b2 expression in infiltrating inflammatory macrophages in sDLL4/28-525 treated mice and might be due to direct inhibition of EC proliferation in laser-induced CNV as demonstrated by EdU labelling in vivo. In conclusion, Notch activation on macrophages and ECs leads to opposing effects in inflammatory neovascularization in situations such as CNV.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10456-012-9290-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3777783", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1119026", 
        "issn": [
          "0969-6970", 
          "1573-7209"
        ], 
        "name": "Angiogenesis", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "keywords": [
      "choroidal neovascularization", 
      "IL-1\u03b2 expression", 
      "inflammatory neovascularization", 
      "endothelial cells", 
      "aortic rings", 
      "more choroidal neovascularization", 
      "laser-induced choroidal neovascularization", 
      "anti-angiogenic effects", 
      "Inhibits Choroidal Neovascularization", 
      "EC proliferation", 
      "pro-angiogenic VEGF", 
      "vascular sprouting", 
      "CD1 mice", 
      "vascular endothelium", 
      "inflammatory macrophages", 
      "neovascularization", 
      "secretase inhibitors", 
      "macrophages", 
      "Notch-4", 
      "Notch-1", 
      "direct inhibition", 
      "mice", 
      "EdU labeling", 
      "Notch pathway", 
      "VEGF", 
      "Notch target genes", 
      "Notch activation", 
      "vivo", 
      "inhibition", 
      "proliferation", 
      "target genes", 
      "sprouting", 
      "overall effect", 
      "cells", 
      "C57BL6", 
      "expression", 
      "endothelium", 
      "effect", 
      "injection", 
      "inhibitors", 
      "activation", 
      "Notch", 
      "soluble fraction", 
      "conclusion", 
      "pathway", 
      "labeling", 
      "genes", 
      "contrast", 
      "presence", 
      "presence of notches", 
      "fraction", 
      "influence", 
      "medium", 
      "situation", 
      "domain", 
      "ring", 
      "main Notch 1", 
      "Ser28-Pro525", 
      "murine extracellular DLL4 domain", 
      "extracellular DLL4 domain", 
      "DLL4 domain", 
      "sDLL4/28-525", 
      "sDLL4/28-525 injections", 
      "Delta-like 4 inhibits choroidal neovascularization"
    ], 
    "name": "Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages", 
    "pagination": "609-622", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026685256"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10456-012-9290-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22869002"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10456-012-9290-0", 
      "https://app.dimensions.ai/details/publication/pub.1026685256"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_585.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10456-012-9290-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10456-012-9290-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10456-012-9290-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10456-012-9290-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10456-012-9290-0'


 

This table displays all metadata directly associated to this object as RDF triples.

361 TRIPLES      22 PREDICATES      112 URIs      95 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10456-012-9290-0 schema:about N033cbebc1bd14f258dd827bbdb6d0afb
2 N08ab17bbb212445a8e6283a763a0e6e2
3 N10bf11e2d84146639b7d96424da343d4
4 N142707f6c9744019a1acfa17c9ec1013
5 N3c9635a6c9424cbcaa02677657bc4bd9
6 N5b2591379d6e4dc4af4c61e37aee8f45
7 N5e37fae4ac9349a88b1b609843303f32
8 N9605f204c364485a9bf48aa762bcfd7d
9 N9de31de2c69e4388ba179c527a5d43f9
10 Nad25fe8b03dc4c02a321383305dd40ff
11 Nd495971efc564a5db3466ec1fada6145
12 Nde7bc19d718b41c3ae71adc240c46a07
13 Nec080461c98145bda937ab51022f81f6
14 anzsrc-for:11
15 anzsrc-for:1107
16 schema:author N8b205d5bd4414c6d8bf830d0659c9fda
17 schema:citation sg:pub.10.1007/3-7643-7311-3_1
18 sg:pub.10.1007/bf00941723
19 sg:pub.10.1007/bf01739641
20 sg:pub.10.1038/329630a0
21 sg:pub.10.1038/35025220
22 sg:pub.10.1038/nature05313
23 sg:pub.10.1038/nature05355
24 sg:pub.10.1038/nature08751
25 sg:pub.10.1038/nature10908
26 schema:datePublished 2012-08-07
27 schema:datePublishedReg 2012-08-07
28 schema:description Inflammatory neovascularization, such as choroidal neovascularization (CNV), occur in the presence of Notch expressing macrophages. DLL4s anti-angiogenic effect on endothelial cells (EC) has been widely recognized, but its influence on Notch signaling on macrophages and its overall effect in inflammatory neovascularization is not well understood. We identified macrophages and ECs as the main Notch 1 and Notch 4 expressing cells in CNV. A soluble fraction spanning Ser28-Pro525 of the murine extracellular DLL4 domain (sDLL4/28-525) activated the Notch pathway, as it induces Notch target genes in macrophages and ECs and inhibited EC proliferation and vascular sprouting in aortic rings. In contrast, sDLL4/28-525 increased pro-angiogenic VEGF, and IL-1β expression in macrophages responsible for increased vascular sprouting observed in aortic rings incubated in conditioned media from sDLL4/28-525 stimulated macrophages. In vivo, Dll4(+/-) mice developed significantly more CNV and sDLL4/28-525 injections inhibited CNV in Dll4(+/-) CD1 mice. Similarly, sDLL4/28-525 inhibited CNV in C57Bl6 and its effect was reversed by a γ-secretase inhibitor that blocks Notch signaling. The inhibition occurred despite increased VEGF, IL-1β expression in infiltrating inflammatory macrophages in sDLL4/28-525 treated mice and might be due to direct inhibition of EC proliferation in laser-induced CNV as demonstrated by EdU labelling in vivo. In conclusion, Notch activation on macrophages and ECs leads to opposing effects in inflammatory neovascularization in situations such as CNV.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree true
32 schema:isPartOf Ne13b643a87bd49afa063c66d83c2b35a
33 Nef713b9495044992b1869e60c2472bd8
34 sg:journal.1119026
35 schema:keywords C57BL6
36 CD1 mice
37 DLL4 domain
38 Delta-like 4 inhibits choroidal neovascularization
39 EC proliferation
40 EdU labeling
41 IL-1β expression
42 Inhibits Choroidal Neovascularization
43 Notch
44 Notch activation
45 Notch pathway
46 Notch target genes
47 Notch-1
48 Notch-4
49 Ser28-Pro525
50 VEGF
51 activation
52 anti-angiogenic effects
53 aortic rings
54 cells
55 choroidal neovascularization
56 conclusion
57 contrast
58 direct inhibition
59 domain
60 effect
61 endothelial cells
62 endothelium
63 expression
64 extracellular DLL4 domain
65 fraction
66 genes
67 inflammatory macrophages
68 inflammatory neovascularization
69 influence
70 inhibition
71 inhibitors
72 injection
73 labeling
74 laser-induced choroidal neovascularization
75 macrophages
76 main Notch 1
77 medium
78 mice
79 more choroidal neovascularization
80 murine extracellular DLL4 domain
81 neovascularization
82 overall effect
83 pathway
84 presence
85 presence of notches
86 pro-angiogenic VEGF
87 proliferation
88 ring
89 sDLL4/28-525
90 sDLL4/28-525 injections
91 secretase inhibitors
92 situation
93 soluble fraction
94 sprouting
95 target genes
96 vascular endothelium
97 vascular sprouting
98 vivo
99 schema:name Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages
100 schema:pagination 609-622
101 schema:productId N0d442641f32349bcac28b94bc3e13e59
102 N180ef031a32740fa96dd84bb14bec6ef
103 Ne9e14fda04484021a9c4620cb08d57ca
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026685256
105 https://doi.org/10.1007/s10456-012-9290-0
106 schema:sdDatePublished 2022-01-01T18:28
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N6a189b3eb6564af7b8c0aae3791b587c
109 schema:url https://doi.org/10.1007/s10456-012-9290-0
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N033cbebc1bd14f258dd827bbdb6d0afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Endothelium, Vascular
115 rdf:type schema:DefinedTerm
116 N08ab17bbb212445a8e6283a763a0e6e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Calcium-Binding Proteins
118 rdf:type schema:DefinedTerm
119 N0d442641f32349bcac28b94bc3e13e59 schema:name dimensions_id
120 schema:value pub.1026685256
121 rdf:type schema:PropertyValue
122 N0f01cfda719b4c75b753ac1a83d76f8e rdf:first sg:person.01052425027.09
123 rdf:rest Nda203ab7609946709f58dfa6beaf30e8
124 N0f119be8686d43039a1eb877be4293c3 rdf:first sg:person.01174402647.29
125 rdf:rest Nfb75b5cfda4c45f991b702d5a2107b45
126 N10bf11e2d84146639b7d96424da343d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Adaptor Proteins, Signal Transducing
128 rdf:type schema:DefinedTerm
129 N142707f6c9744019a1acfa17c9ec1013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Animals
131 rdf:type schema:DefinedTerm
132 N142bcbaddde24dd08fa1ee078ca5c260 rdf:first sg:person.0736717332.12
133 rdf:rest Ndd9ed7eb09c74fbc8214ce6cebd1aec3
134 N180ef031a32740fa96dd84bb14bec6ef schema:name doi
135 schema:value 10.1007/s10456-012-9290-0
136 rdf:type schema:PropertyValue
137 N3c9635a6c9424cbcaa02677657bc4bd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name DNA Primers
139 rdf:type schema:DefinedTerm
140 N406771f3a6d34f5c9e6eaa1a9b73a7da rdf:first sg:person.01267244556.32
141 rdf:rest N0f119be8686d43039a1eb877be4293c3
142 N5b2591379d6e4dc4af4c61e37aee8f45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mice, Inbred C57BL
144 rdf:type schema:DefinedTerm
145 N5e37fae4ac9349a88b1b609843303f32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Choroidal Neovascularization
147 rdf:type schema:DefinedTerm
148 N64cd8084e0af416e825ce8e397e1e942 rdf:first sg:person.01173454717.01
149 rdf:rest Nb45b91d992e64569a285c6565284be79
150 N6a189b3eb6564af7b8c0aae3791b587c schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 N8b205d5bd4414c6d8bf830d0659c9fda rdf:first sg:person.01337534012.31
153 rdf:rest Nc3c0b91064d9447db41d4a5fe0362b6f
154 N9408171f1f19441482d9f28b2056a098 rdf:first sg:person.0771260323.69
155 rdf:rest N406771f3a6d34f5c9e6eaa1a9b73a7da
156 N9605f204c364485a9bf48aa762bcfd7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Blotting, Western
158 rdf:type schema:DefinedTerm
159 N9de31de2c69e4388ba179c527a5d43f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Mice
161 rdf:type schema:DefinedTerm
162 Nacd5a5d38932441b9a62da09a0d221fe rdf:first sg:person.01355754077.61
163 rdf:rest N9408171f1f19441482d9f28b2056a098
164 Nad25fe8b03dc4c02a321383305dd40ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Intercellular Signaling Peptides and Proteins
166 rdf:type schema:DefinedTerm
167 Nb45b91d992e64569a285c6565284be79 rdf:first sg:person.01366453064.75
168 rdf:rest Nf74e2f8a79ed41b9a4db784846170bfa
169 Nc3c0b91064d9447db41d4a5fe0362b6f rdf:first sg:person.01047304632.44
170 rdf:rest Ne694bede21974f88b261454e4684441d
171 Nc7635f41b48a49b0b6ecd27a9b3f15e6 rdf:first sg:person.01132655726.95
172 rdf:rest Nf4960604d5a54c4a80144b5c91860888
173 Nd495971efc564a5db3466ec1fada6145 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Base Sequence
175 rdf:type schema:DefinedTerm
176 Nda203ab7609946709f58dfa6beaf30e8 rdf:first sg:person.011434217642.09
177 rdf:rest N64cd8084e0af416e825ce8e397e1e942
178 Ndd9ed7eb09c74fbc8214ce6cebd1aec3 rdf:first sg:person.01356263054.39
179 rdf:rest rdf:nil
180 Nde7bc19d718b41c3ae71adc240c46a07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Macrophages, Peritoneal
182 rdf:type schema:DefinedTerm
183 Ne13b643a87bd49afa063c66d83c2b35a schema:issueNumber 4
184 rdf:type schema:PublicationIssue
185 Ne694bede21974f88b261454e4684441d rdf:first sg:person.0727671641.74
186 rdf:rest Nacd5a5d38932441b9a62da09a0d221fe
187 Ne9e14fda04484021a9c4620cb08d57ca schema:name pubmed_id
188 schema:value 22869002
189 rdf:type schema:PropertyValue
190 Nec080461c98145bda937ab51022f81f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Reverse Transcriptase Polymerase Chain Reaction
192 rdf:type schema:DefinedTerm
193 Nef713b9495044992b1869e60c2472bd8 schema:volumeNumber 15
194 rdf:type schema:PublicationVolume
195 Nf4960604d5a54c4a80144b5c91860888 rdf:first sg:person.0716330041.50
196 rdf:rest N142bcbaddde24dd08fa1ee078ca5c260
197 Nf74e2f8a79ed41b9a4db784846170bfa rdf:first sg:person.0731014456.26
198 rdf:rest Nc7635f41b48a49b0b6ecd27a9b3f15e6
199 Nfb75b5cfda4c45f991b702d5a2107b45 rdf:first sg:person.01130310301.78
200 rdf:rest N0f01cfda719b4c75b753ac1a83d76f8e
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
205 schema:name Immunology
206 rdf:type schema:DefinedTerm
207 sg:grant.3777783 http://pending.schema.org/fundedItem sg:pub.10.1007/s10456-012-9290-0
208 rdf:type schema:MonetaryGrant
209 sg:journal.1119026 schema:issn 0969-6970
210 1573-7209
211 schema:name Angiogenesis
212 schema:publisher Springer Nature
213 rdf:type schema:Periodical
214 sg:person.01047304632.44 schema:affiliation grid-institutes:grid.4444.0
215 schema:familyName Raoul
216 schema:givenName William
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047304632.44
218 rdf:type schema:Person
219 sg:person.01052425027.09 schema:affiliation grid-institutes:grid.508487.6
220 schema:familyName Jonet
221 schema:givenName Laurent
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052425027.09
223 rdf:type schema:Person
224 sg:person.01130310301.78 schema:affiliation grid-institutes:grid.457348.9
225 schema:familyName Sulpice
226 schema:givenName Eric
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130310301.78
228 rdf:type schema:Person
229 sg:person.01132655726.95 schema:affiliation grid-institutes:grid.462887.7
230 schema:familyName Eichmann
231 schema:givenName Anne
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132655726.95
233 rdf:type schema:Person
234 sg:person.011434217642.09 schema:affiliation grid-institutes:grid.417925.c
235 schema:familyName Klein
236 schema:givenName Christophe
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011434217642.09
238 rdf:type schema:Person
239 sg:person.01173454717.01 schema:affiliation grid-institutes:grid.417925.c
240 schema:familyName Devevre
241 schema:givenName Estelle
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173454717.01
243 rdf:type schema:Person
244 sg:person.01174402647.29 schema:affiliation grid-institutes:grid.508487.6
245 schema:familyName Houssier
246 schema:givenName Marianne
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174402647.29
248 rdf:type schema:Person
249 sg:person.01267244556.32 schema:affiliation grid-institutes:grid.4444.0
250 schema:familyName Levy
251 schema:givenName Olivier
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267244556.32
253 rdf:type schema:Person
254 sg:person.01337534012.31 schema:affiliation grid-institutes:grid.508487.6
255 schema:familyName Camelo
256 schema:givenName Serge
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337534012.31
258 rdf:type schema:Person
259 sg:person.01355754077.61 schema:affiliation grid-institutes:grid.4444.0
260 schema:familyName Calippe
261 schema:givenName Bertrand
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355754077.61
263 rdf:type schema:Person
264 sg:person.01356263054.39 schema:affiliation grid-institutes:grid.418241.a
265 schema:familyName Sennlaub
266 schema:givenName Florian
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39
268 rdf:type schema:Person
269 sg:person.01366453064.75 schema:affiliation grid-institutes:None
270 schema:familyName Thuret
271 schema:givenName Gilles
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366453064.75
273 rdf:type schema:Person
274 sg:person.0716330041.50 schema:affiliation grid-institutes:grid.463770.1
275 schema:familyName Leconte
276 schema:givenName Laurence
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716330041.50
278 rdf:type schema:Person
279 sg:person.0727671641.74 schema:affiliation grid-institutes:grid.4444.0
280 schema:familyName Lavalette
281 schema:givenName Sophie
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727671641.74
283 rdf:type schema:Person
284 sg:person.0731014456.26 schema:affiliation grid-institutes:grid.418346.c
285 schema:familyName Duarte
286 schema:givenName Antonio
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731014456.26
288 rdf:type schema:Person
289 sg:person.0736717332.12 schema:affiliation grid-institutes:grid.4444.0
290 schema:familyName Guillonneau
291 schema:givenName Xavier
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736717332.12
293 rdf:type schema:Person
294 sg:person.0771260323.69 schema:affiliation grid-institutes:grid.462887.7
295 schema:familyName Cristofaro
296 schema:givenName Brunella
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771260323.69
298 rdf:type schema:Person
299 sg:pub.10.1007/3-7643-7311-3_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001296347
300 https://doi.org/10.1007/3-7643-7311-3_1
301 rdf:type schema:CreativeWork
302 sg:pub.10.1007/bf00941723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021732396
303 https://doi.org/10.1007/bf00941723
304 rdf:type schema:CreativeWork
305 sg:pub.10.1007/bf01739641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027664151
306 https://doi.org/10.1007/bf01739641
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/329630a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008055718
309 https://doi.org/10.1038/329630a0
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/35025220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043028620
312 https://doi.org/10.1038/35025220
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/nature05313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553835
315 https://doi.org/10.1038/nature05313
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/nature05355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037678066
318 https://doi.org/10.1038/nature05355
319 rdf:type schema:CreativeWork
320 sg:pub.10.1038/nature08751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007799896
321 https://doi.org/10.1038/nature08751
322 rdf:type schema:CreativeWork
323 sg:pub.10.1038/nature10908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029404187
324 https://doi.org/10.1038/nature10908
325 rdf:type schema:CreativeWork
326 grid-institutes:None schema:alternateName Assistance Publique des Hôpitaux de St Etienne, Centre hospitalier universitaire de Saint-Etienne, Université Jean Monnet; Faculté de Médecine, St Etienne, France
327 schema:name Assistance Publique des Hôpitaux de St Etienne, Centre hospitalier universitaire de Saint-Etienne, Université Jean Monnet; Faculté de Médecine, St Etienne, France
328 rdf:type schema:Organization
329 grid-institutes:grid.417925.c schema:alternateName Plateforme d’imagerie, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMR S 872, Paris, France
330 schema:name Plateforme d’imagerie, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMR S 872, Paris, France
331 rdf:type schema:Organization
332 grid-institutes:grid.418241.a schema:alternateName Equipe 14, Institut de la Vision, 17, rue Moreau, 75012 Paris, France
333 schema:name CNRS, UMR_7210, 75012 Paris, France
334 Equipe 14, Institut de la Vision, 17, rue Moreau, 75012 Paris, France
335 Hôtel-Dieu Hospital, Department of Ophthalmology, APHP, Paris, France
336 Inflammation, dégénérescence et remodelage vasculaire dans les pathologies rétiniennes», Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France
337 Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France
338 rdf:type schema:Organization
339 grid-institutes:grid.418346.c schema:alternateName Instituto Gulbenkian de Ciência, 2781-901 Oeiras, Portugal
340 schema:name CIISA, Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal
341 Instituto Gulbenkian de Ciência, 2781-901 Oeiras, Portugal
342 rdf:type schema:Organization
343 grid-institutes:grid.4444.0 schema:alternateName CNRS, UMR_7210, 75012 Paris, France
344 schema:name CNRS, UMR_7210, 75012 Paris, France
345 Inflammation, dégénérescence et remodelage vasculaire dans les pathologies rétiniennes», Institut de la Vision, INSERM UMRS 968, 17 rue Moreau, 75012 Paris, France
346 Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 75012 Paris, France
347 rdf:type schema:Organization
348 grid-institutes:grid.457348.9 schema:alternateName CEA Grenoble, DSV/iRTSV/BGE(INSERM U-1038)/Biomics, 17 rue des Martyrs, 38054 Grenoble, France
349 schema:name CEA Grenoble, DSV/iRTSV/BGE(INSERM U-1038)/Biomics, 17 rue des Martyrs, 38054 Grenoble, France
350 rdf:type schema:Organization
351 grid-institutes:grid.462887.7 schema:alternateName CIRB, Collège de France, CNRS UMR 7241/Inserm U1050, Paris, France
352 schema:name CIRB, Collège de France, CNRS UMR 7241/Inserm U1050, Paris, France
353 rdf:type schema:Organization
354 grid-institutes:grid.463770.1 schema:alternateName Sisène; Paris Biotech Santé, Paris, France
355 schema:name Sisène; Paris Biotech Santé, Paris, France
356 rdf:type schema:Organization
357 grid-institutes:grid.508487.6 schema:alternateName Université Paris Descartes, UMR S 872, 75006 Paris, France
358 schema:name Centre de Recherche des Cordeliers, INSERM, UMR S 872, 75006 Paris, France
359 UPMC Univ Paris 06, UMR S 872, 75006 Paris, France
360 Université Paris Descartes, UMR S 872, 75006 Paris, France
361 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...