In vivo Evaluation of Cenderitide-Eluting Stent (CES) II View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07-16

AUTHORS

Yingying Huang, Xu Wen Ng, Soon Ghim Lim, Horng Haur Chen, John C. Burnett, Yin Chiang Freddy Boey, Subbu S. Venkatraman

ABSTRACT

The use of drug-eluting coronary stents has led to significant reduction in in-stent restenosis (ISR), but led to delayed endothelialization, necessitating the prolonged use of expensive anti-thrombotic drugs with their side-effects. Cenderitide (CD-NP) is a novel anti-proliferative chimeric peptide of semi-endothelial origin. Our previous work in vitro has demonstrated; that the smooth muscle cells were inhibited significantly more than endothelial cells which is the desirable feature of an anti-restenosis drug. This work reports the effects of implantation of a centeritide-eluting stent (CES) on ISR and endothelialization in an in vivo model. CESs were produced by coating bare metallic stents with CD-NP entrapped in biodegradable poly(ε-caprolactone) using an ultrasonic spray coater. A total of 32 stents were successfully implanted into 16 pigs, and all animal survived for 28 days. The plasma levels of CD-NP were significantly higher in the CES group than in the control group (bare metal stents and polymer-coated stent) at post-stenting, indicating the successful release of CD-NP from the stent in vivo. Furthermore, SEM analysis results showed the greater endothelial coverage of the stent struts, as well as between the struts in CES group. Moreover, histological results showed mild inflammation, and low fibrin score at 28 days. However, plasma cGMP (second messenger, cyclic 3′,5′ guanosine monophosphate) does not show a significant difference, and the CES is also unable to show significant difference in terms on neointimal area and stenosis, in comparison to BMS at 28 days. More... »

PAGES

432-441

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1

DOI

http://dx.doi.org/10.1007/s10439-015-1389-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021027359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26178873


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biomedical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Absorbable Implants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coated Materials, Biocompatible", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug-Eluting Stents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Materials Testing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Natriuretic Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyesters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Snake Venoms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore", 
          "id": "http://www.grid.ac/institutes/grid.59025.3b", 
          "name": [
            "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Yingying", 
        "id": "sg:person.01275417272.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275417272.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore", 
          "id": "http://www.grid.ac/institutes/grid.59025.3b", 
          "name": [
            "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Xu Wen", 
        "id": "sg:person.01343532472.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343532472.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore", 
          "id": "http://www.grid.ac/institutes/grid.59025.3b", 
          "name": [
            "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lim", 
        "givenName": "Soon Ghim", 
        "id": "sg:person.01326264732.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326264732.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Horng Haur", 
        "id": "sg:person.01024326700.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024326700.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burnett", 
        "givenName": "John C.", 
        "id": "sg:person.01001266776.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001266776.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore", 
          "id": "http://www.grid.ac/institutes/grid.59025.3b", 
          "name": [
            "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boey", 
        "givenName": "Yin Chiang Freddy", 
        "id": "sg:person.0627336633.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627336633.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore", 
          "id": "http://www.grid.ac/institutes/grid.59025.3b", 
          "name": [
            "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Venkatraman", 
        "givenName": "Subbu S.", 
        "id": "sg:person.0734354772.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734354772.00"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2015-07-16", 
    "datePublishedReg": "2015-07-16", 
    "description": "Abstract\nThe use of drug-eluting coronary stents has led to significant reduction in in-stent restenosis (ISR), but led to delayed endothelialization, necessitating the prolonged use of expensive anti-thrombotic drugs with their side-effects. Cenderitide (CD-NP) is a novel anti-proliferative chimeric peptide of semi-endothelial origin. Our previous work in vitro has demonstrated; that the smooth muscle cells were inhibited significantly more than endothelial cells which is the desirable feature of an anti-restenosis drug. This work reports the effects of implantation of a centeritide-eluting stent (CES) on ISR and endothelialization in an in vivo model. CESs were produced by coating bare metallic stents with CD-NP entrapped in biodegradable poly(\u03b5-caprolactone) using an ultrasonic spray coater. A total of 32 stents were successfully implanted into 16 pigs, and all animal survived for 28\u00a0days. The plasma levels of CD-NP were significantly higher in the CES group than in the control group (bare metal stents and polymer-coated stent) at post-stenting, indicating the successful release of CD-NP from the stent in vivo. Furthermore, SEM analysis results showed the greater endothelial coverage of the stent struts, as well as between the struts in CES group. Moreover, histological results showed mild inflammation, and low fibrin score at 28\u00a0days. However, plasma cGMP (second messenger, cyclic 3\u2032,5\u2032 guanosine monophosphate) does not show a significant difference, and the CES is also unable to show significant difference in terms on neointimal area and stenosis, in comparison to BMS at 28\u00a0days.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10439-015-1389-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2540817", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1087247", 
        "issn": [
          "0145-3068", 
          "1573-9686"
        ], 
        "name": "Annals of Biomedical Engineering", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "keywords": [
      "ultrasonic spray coater", 
      "spray coater", 
      "SEM analysis results", 
      "anti-restenosis drug", 
      "effect of implantation", 
      "bare metallic stents", 
      "analysis results", 
      "struts", 
      "CdS NPs", 
      "stent struts", 
      "endothelialization", 
      "coater", 
      "desirable features", 
      "coronary stents", 
      "endothelial coverage", 
      "drug-eluting coronary stents", 
      "work", 
      "previous work", 
      "vivo evaluation", 
      "successful release", 
      "results", 
      "metallic stents", 
      "stents", 
      "model", 
      "use", 
      "reduction", 
      "implantation", 
      "significant reduction", 
      "stent restenosis", 
      "Cenderitide", 
      "comparison", 
      "terms", 
      "effect", 
      "area", 
      "features", 
      "neointimal area", 
      "CES group", 
      "coverage", 
      "evaluation", 
      "release", 
      "BMS", 
      "histological results", 
      "differences", 
      "cells", 
      "prolonged use", 
      "levels", 
      "days", 
      "ISR", 
      "fibrin", 
      "significant differences", 
      "restenosis", 
      "origin", 
      "group", 
      "mild inflammation", 
      "endothelial cells", 
      "vivo model", 
      "vivo", 
      "smooth muscle cells", 
      "anti-thrombotic drugs", 
      "drugs", 
      "vitro", 
      "muscle cells", 
      "total", 
      "stenosis", 
      "pigs", 
      "control group", 
      "animals", 
      "chimeric peptide", 
      "plasma cGMP", 
      "peptides", 
      "plasma levels", 
      "inflammation", 
      "cGMP"
    ], 
    "name": "In vivo Evaluation of Cenderitide-Eluting Stent (CES) II", 
    "pagination": "432-441", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021027359"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10439-015-1389-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26178873"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10439-015-1389-1", 
      "https://app.dimensions.ai/details/publication/pub.1021027359"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_654.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10439-015-1389-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'


 

This table displays all metadata directly associated to this object as RDF triples.

226 TRIPLES      21 PREDICATES      110 URIs      102 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10439-015-1389-1 schema:about N1f9ad11357e44d31a72a07acfe5e3aa7
2 N20134bba233a43349d794543791d92da
3 N211754a4a9e442bcac76a2e2f287b780
4 N279da1d2d49b45f1bdcf3cdbbddb7a41
5 N34e0c918b418413aa198371a4d52fac5
6 N4ed120b5329a4f909535d6230c8adb9d
7 N516abaed242f47d3a0be354d9edcef2f
8 N6cf454d8a7f74ec49f7b505fa54332a9
9 N95e31db6b8194bc3a2e2b59e739d897e
10 Nca2bee1a1ad24ddd8e4caf09a09671c0
11 Nfb304364c4f544f89a065be7e1231406
12 anzsrc-for:09
13 anzsrc-for:0903
14 schema:author N3be1f8c9f28a4165b2c7ba0fc7b3cf47
15 schema:datePublished 2015-07-16
16 schema:datePublishedReg 2015-07-16
17 schema:description Abstract The use of drug-eluting coronary stents has led to significant reduction in in-stent restenosis (ISR), but led to delayed endothelialization, necessitating the prolonged use of expensive anti-thrombotic drugs with their side-effects. Cenderitide (CD-NP) is a novel anti-proliferative chimeric peptide of semi-endothelial origin. Our previous work in vitro has demonstrated; that the smooth muscle cells were inhibited significantly more than endothelial cells which is the desirable feature of an anti-restenosis drug. This work reports the effects of implantation of a centeritide-eluting stent (CES) on ISR and endothelialization in an in vivo model. CESs were produced by coating bare metallic stents with CD-NP entrapped in biodegradable poly(ε-caprolactone) using an ultrasonic spray coater. A total of 32 stents were successfully implanted into 16 pigs, and all animal survived for 28 days. The plasma levels of CD-NP were significantly higher in the CES group than in the control group (bare metal stents and polymer-coated stent) at post-stenting, indicating the successful release of CD-NP from the stent in vivo. Furthermore, SEM analysis results showed the greater endothelial coverage of the stent struts, as well as between the struts in CES group. Moreover, histological results showed mild inflammation, and low fibrin score at 28 days. However, plasma cGMP (second messenger, cyclic 3′,5′ guanosine monophosphate) does not show a significant difference, and the CES is also unable to show significant difference in terms on neointimal area and stenosis, in comparison to BMS at 28 days.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree true
21 schema:isPartOf N1f0aab47ca6942b3ba4ba862562462c4
22 N980ab4a225a24c86bbb568f57ca66459
23 sg:journal.1087247
24 schema:keywords BMS
25 CES group
26 CdS NPs
27 Cenderitide
28 ISR
29 SEM analysis results
30 analysis results
31 animals
32 anti-restenosis drug
33 anti-thrombotic drugs
34 area
35 bare metallic stents
36 cGMP
37 cells
38 chimeric peptide
39 coater
40 comparison
41 control group
42 coronary stents
43 coverage
44 days
45 desirable features
46 differences
47 drug-eluting coronary stents
48 drugs
49 effect
50 effect of implantation
51 endothelial cells
52 endothelial coverage
53 endothelialization
54 evaluation
55 features
56 fibrin
57 group
58 histological results
59 implantation
60 inflammation
61 levels
62 metallic stents
63 mild inflammation
64 model
65 muscle cells
66 neointimal area
67 origin
68 peptides
69 pigs
70 plasma cGMP
71 plasma levels
72 previous work
73 prolonged use
74 reduction
75 release
76 restenosis
77 results
78 significant differences
79 significant reduction
80 smooth muscle cells
81 spray coater
82 stenosis
83 stent restenosis
84 stent struts
85 stents
86 struts
87 successful release
88 terms
89 total
90 ultrasonic spray coater
91 use
92 vitro
93 vivo
94 vivo evaluation
95 vivo model
96 work
97 schema:name In vivo Evaluation of Cenderitide-Eluting Stent (CES) II
98 schema:pagination 432-441
99 schema:productId N25393a3fbdd2461f818244baa38df524
100 N3ff53373479c4926b91957c9d9088b60
101 Nd543abe11feb44a8bc490d5c76cc0c27
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021027359
103 https://doi.org/10.1007/s10439-015-1389-1
104 schema:sdDatePublished 2022-05-20T07:30
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher Ncbb6bf1e43d14d3cb4cdc83758cf7930
107 schema:url https://doi.org/10.1007/s10439-015-1389-1
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N1f0aab47ca6942b3ba4ba862562462c4 schema:volumeNumber 44
112 rdf:type schema:PublicationVolume
113 N1f9ad11357e44d31a72a07acfe5e3aa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Female
115 rdf:type schema:DefinedTerm
116 N20134bba233a43349d794543791d92da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Natriuretic Peptides
118 rdf:type schema:DefinedTerm
119 N211754a4a9e442bcac76a2e2f287b780 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Animals
121 rdf:type schema:DefinedTerm
122 N25393a3fbdd2461f818244baa38df524 schema:name pubmed_id
123 schema:value 26178873
124 rdf:type schema:PropertyValue
125 N279da1d2d49b45f1bdcf3cdbbddb7a41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Materials Testing
127 rdf:type schema:DefinedTerm
128 N34e0c918b418413aa198371a4d52fac5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Coated Materials, Biocompatible
130 rdf:type schema:DefinedTerm
131 N3be1f8c9f28a4165b2c7ba0fc7b3cf47 rdf:first sg:person.01275417272.70
132 rdf:rest Nc8646079589545c0ba404ef94f99e42a
133 N3d627242052e45698c2e424d271f0519 rdf:first sg:person.01001266776.01
134 rdf:rest Nf4f8901d0f8842b5b68782ab2ac608b4
135 N3ff53373479c4926b91957c9d9088b60 schema:name dimensions_id
136 schema:value pub.1021027359
137 rdf:type schema:PropertyValue
138 N4ed120b5329a4f909535d6230c8adb9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Swine
140 rdf:type schema:DefinedTerm
141 N516abaed242f47d3a0be354d9edcef2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Snake Venoms
143 rdf:type schema:DefinedTerm
144 N6cf454d8a7f74ec49f7b505fa54332a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Absorbable Implants
146 rdf:type schema:DefinedTerm
147 N95e31db6b8194bc3a2e2b59e739d897e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Endothelial Cells
149 rdf:type schema:DefinedTerm
150 N980ab4a225a24c86bbb568f57ca66459 schema:issueNumber 2
151 rdf:type schema:PublicationIssue
152 Nc592b95a268341698a8730cedf2b3e4e rdf:first sg:person.01326264732.34
153 rdf:rest Nf5a82b40c5424349a8d94e60729a9d8b
154 Nc8646079589545c0ba404ef94f99e42a rdf:first sg:person.01343532472.25
155 rdf:rest Nc592b95a268341698a8730cedf2b3e4e
156 Nca2bee1a1ad24ddd8e4caf09a09671c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Drug-Eluting Stents
158 rdf:type schema:DefinedTerm
159 Ncbb6bf1e43d14d3cb4cdc83758cf7930 schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Nd543abe11feb44a8bc490d5c76cc0c27 schema:name doi
162 schema:value 10.1007/s10439-015-1389-1
163 rdf:type schema:PropertyValue
164 Nf3260ebcba3d47e6a00588147adf0855 rdf:first sg:person.0734354772.00
165 rdf:rest rdf:nil
166 Nf4f8901d0f8842b5b68782ab2ac608b4 rdf:first sg:person.0627336633.01
167 rdf:rest Nf3260ebcba3d47e6a00588147adf0855
168 Nf5a82b40c5424349a8d94e60729a9d8b rdf:first sg:person.01024326700.50
169 rdf:rest N3d627242052e45698c2e424d271f0519
170 Nfb304364c4f544f89a065be7e1231406 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Polyesters
172 rdf:type schema:DefinedTerm
173 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
174 schema:name Engineering
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biomedical Engineering
178 rdf:type schema:DefinedTerm
179 sg:grant.2540817 http://pending.schema.org/fundedItem sg:pub.10.1007/s10439-015-1389-1
180 rdf:type schema:MonetaryGrant
181 sg:journal.1087247 schema:issn 0145-3068
182 1573-9686
183 schema:name Annals of Biomedical Engineering
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01001266776.01 schema:affiliation grid-institutes:grid.66875.3a
187 schema:familyName Burnett
188 schema:givenName John C.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001266776.01
190 rdf:type schema:Person
191 sg:person.01024326700.50 schema:affiliation grid-institutes:grid.66875.3a
192 schema:familyName Chen
193 schema:givenName Horng Haur
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024326700.50
195 rdf:type schema:Person
196 sg:person.01275417272.70 schema:affiliation grid-institutes:grid.59025.3b
197 schema:familyName Huang
198 schema:givenName Yingying
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275417272.70
200 rdf:type schema:Person
201 sg:person.01326264732.34 schema:affiliation grid-institutes:grid.59025.3b
202 schema:familyName Lim
203 schema:givenName Soon Ghim
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326264732.34
205 rdf:type schema:Person
206 sg:person.01343532472.25 schema:affiliation grid-institutes:grid.59025.3b
207 schema:familyName Ng
208 schema:givenName Xu Wen
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343532472.25
210 rdf:type schema:Person
211 sg:person.0627336633.01 schema:affiliation grid-institutes:grid.59025.3b
212 schema:familyName Boey
213 schema:givenName Yin Chiang Freddy
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627336633.01
215 rdf:type schema:Person
216 sg:person.0734354772.00 schema:affiliation grid-institutes:grid.59025.3b
217 schema:familyName Venkatraman
218 schema:givenName Subbu S.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734354772.00
220 rdf:type schema:Person
221 grid-institutes:grid.59025.3b schema:alternateName School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore
222 schema:name School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore
223 rdf:type schema:Organization
224 grid-institutes:grid.66875.3a schema:alternateName Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA
225 schema:name Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA
226 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...