Ontology type: schema:ScholarlyArticle Open Access: True
2015-07-16
AUTHORSYingying Huang, Xu Wen Ng, Soon Ghim Lim, Horng Haur Chen, John C. Burnett, Yin Chiang Freddy Boey, Subbu S. Venkatraman
ABSTRACTThe use of drug-eluting coronary stents has led to significant reduction in in-stent restenosis (ISR), but led to delayed endothelialization, necessitating the prolonged use of expensive anti-thrombotic drugs with their side-effects. Cenderitide (CD-NP) is a novel anti-proliferative chimeric peptide of semi-endothelial origin. Our previous work in vitro has demonstrated; that the smooth muscle cells were inhibited significantly more than endothelial cells which is the desirable feature of an anti-restenosis drug. This work reports the effects of implantation of a centeritide-eluting stent (CES) on ISR and endothelialization in an in vivo model. CESs were produced by coating bare metallic stents with CD-NP entrapped in biodegradable poly(ε-caprolactone) using an ultrasonic spray coater. A total of 32 stents were successfully implanted into 16 pigs, and all animal survived for 28 days. The plasma levels of CD-NP were significantly higher in the CES group than in the control group (bare metal stents and polymer-coated stent) at post-stenting, indicating the successful release of CD-NP from the stent in vivo. Furthermore, SEM analysis results showed the greater endothelial coverage of the stent struts, as well as between the struts in CES group. Moreover, histological results showed mild inflammation, and low fibrin score at 28 days. However, plasma cGMP (second messenger, cyclic 3′,5′ guanosine monophosphate) does not show a significant difference, and the CES is also unable to show significant difference in terms on neointimal area and stenosis, in comparison to BMS at 28 days. More... »
PAGES432-441
http://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1
DOIhttp://dx.doi.org/10.1007/s10439-015-1389-1
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1021027359
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26178873
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Engineering",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biomedical Engineering",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Absorbable Implants",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coated Materials, Biocompatible",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug-Eluting Stents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Endothelial Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Materials Testing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Natriuretic Peptides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyesters",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Snake Venoms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Swine",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore",
"id": "http://www.grid.ac/institutes/grid.59025.3b",
"name": [
"School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Huang",
"givenName": "Yingying",
"id": "sg:person.01275417272.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275417272.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore",
"id": "http://www.grid.ac/institutes/grid.59025.3b",
"name": [
"School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Ng",
"givenName": "Xu Wen",
"id": "sg:person.01343532472.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343532472.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore",
"id": "http://www.grid.ac/institutes/grid.59025.3b",
"name": [
"School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Lim",
"givenName": "Soon Ghim",
"id": "sg:person.01326264732.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326264732.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Horng Haur",
"id": "sg:person.01024326700.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024326700.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA"
],
"type": "Organization"
},
"familyName": "Burnett",
"givenName": "John C.",
"id": "sg:person.01001266776.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001266776.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore",
"id": "http://www.grid.ac/institutes/grid.59025.3b",
"name": [
"School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Boey",
"givenName": "Yin Chiang Freddy",
"id": "sg:person.0627336633.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627336633.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore",
"id": "http://www.grid.ac/institutes/grid.59025.3b",
"name": [
"School of Materials Science & Engineering, Nanyang Technological University, Block N4.1-02-06 Nanyang Avenue, 639798, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Venkatraman",
"givenName": "Subbu S.",
"id": "sg:person.0734354772.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734354772.00"
],
"type": "Person"
}
],
"datePublished": "2015-07-16",
"datePublishedReg": "2015-07-16",
"description": "Abstract\nThe use of drug-eluting coronary stents has led to significant reduction in in-stent restenosis (ISR), but led to delayed endothelialization, necessitating the prolonged use of expensive anti-thrombotic drugs with their side-effects. Cenderitide (CD-NP) is a novel anti-proliferative chimeric peptide of semi-endothelial origin. Our previous work in vitro has demonstrated; that the smooth muscle cells were inhibited significantly more than endothelial cells which is the desirable feature of an anti-restenosis drug. This work reports the effects of implantation of a centeritide-eluting stent (CES) on ISR and endothelialization in an in vivo model. CESs were produced by coating bare metallic stents with CD-NP entrapped in biodegradable poly(\u03b5-caprolactone) using an ultrasonic spray coater. A total of 32 stents were successfully implanted into 16 pigs, and all animal survived for 28\u00a0days. The plasma levels of CD-NP were significantly higher in the CES group than in the control group (bare metal stents and polymer-coated stent) at post-stenting, indicating the successful release of CD-NP from the stent in vivo. Furthermore, SEM analysis results showed the greater endothelial coverage of the stent struts, as well as between the struts in CES group. Moreover, histological results showed mild inflammation, and low fibrin score at 28\u00a0days. However, plasma cGMP (second messenger, cyclic 3\u2032,5\u2032 guanosine monophosphate) does not show a significant difference, and the CES is also unable to show significant difference in terms on neointimal area and stenosis, in comparison to BMS at 28\u00a0days.",
"genre": "article",
"id": "sg:pub.10.1007/s10439-015-1389-1",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2540817",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1087247",
"issn": [
"0145-3068",
"1573-9686"
],
"name": "Annals of Biomedical Engineering",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "44"
}
],
"keywords": [
"ultrasonic spray coater",
"spray coater",
"SEM analysis results",
"anti-restenosis drug",
"effect of implantation",
"bare metallic stents",
"analysis results",
"struts",
"CdS NPs",
"stent struts",
"endothelialization",
"coater",
"desirable features",
"coronary stents",
"endothelial coverage",
"drug-eluting coronary stents",
"work",
"previous work",
"vivo evaluation",
"successful release",
"results",
"metallic stents",
"stents",
"model",
"use",
"reduction",
"implantation",
"significant reduction",
"stent restenosis",
"Cenderitide",
"comparison",
"terms",
"effect",
"area",
"features",
"neointimal area",
"CES group",
"coverage",
"evaluation",
"release",
"BMS",
"histological results",
"differences",
"cells",
"prolonged use",
"levels",
"days",
"ISR",
"fibrin",
"significant differences",
"restenosis",
"origin",
"group",
"mild inflammation",
"endothelial cells",
"vivo model",
"vivo",
"smooth muscle cells",
"anti-thrombotic drugs",
"drugs",
"vitro",
"muscle cells",
"total",
"stenosis",
"pigs",
"control group",
"animals",
"chimeric peptide",
"plasma cGMP",
"peptides",
"plasma levels",
"inflammation",
"cGMP",
"expensive anti-thrombotic drugs",
"novel anti-proliferative chimeric peptide",
"anti-proliferative chimeric peptide",
"semi-endothelial origin",
"CES",
"greater endothelial coverage",
"low fibrin",
"Cenderitide-Eluting Stent (CES) II",
"Stent (CES) II"
],
"name": "In vivo Evaluation of Cenderitide-Eluting Stent (CES) II",
"pagination": "432-441",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1021027359"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10439-015-1389-1"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26178873"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10439-015-1389-1",
"https://app.dimensions.ai/details/publication/pub.1021027359"
],
"sdDataset": "articles",
"sdDatePublished": "2022-01-01T18:36",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_663.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s10439-015-1389-1"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10439-015-1389-1'
This table displays all metadata directly associated to this object as RDF triples.
235 TRIPLES
21 PREDICATES
119 URIs
111 LITERALS
18 BLANK NODES