Indikationen und Ergebnisse der Lungentransplantation bei idiopathischer Lungenfibrose View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-03

AUTHORS

J. Gottlieb

ABSTRACT

Die Lungentransplantation (LTx) ist eine etablierte Therapieoption für Patienten im Endstadium verschiedener nichtmaligner Lungenkrankheiten. Derzeit beträgt die weltweite Aktivität ca. 3500 Prozeduren pro Jahr. Leider führt die Verknappung von Spenderorganen dazu, dass etwa jeder sechste Patient in den westlichen Ländern vor Verfügbarkeit eines Spenderorgans auf der Warteliste verstirbt. Die häufigsten zugrundeliegenden klinischen Indikationen sind Emphysem, Lungenfibrose, und Mukoviszidose. Weltweit hatten in der letzten veröffentlichen Analyse des internationalen Registers 23% aller Empfänger die Diagnose einer idiopathischen Lungenfibrose (IPF). In erfahrenen Zentren werden die Kandidaten zur Lungentransplantation nach krankheitsspezifischen Kriterien unter dem Aspekt der Prognoseverbesserung nach Ausschluss von Kontraindikationen ausgewählt. Allerdings gibt es mehrere Herausforderungen für die LTx. Der Erfolg der Lungentransplantation wird begrenzt durch den Mangel an Spenderorganen. Im Vergleich zu anderen Formen der Organtransplantation sind die Langzeitüberlebensraten noch unterlegen. Dennoch bietet die LTx einen Überlebensvorteil bei sorgfältig ausgewählten Patienten vor allem mit interstitiellen Lungenkrankheiten und besonders der IPF. More... »

PAGES

112-119

References to SciGraph publications

Journal

TITLE

Der Pneumologe

ISSUE

2

VOLUME

10

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10405-012-0609-8

DOI

http://dx.doi.org/10.1007/s10405-012-0609-8

DIMENSIONS

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