Evaluation of the efficacy of Hypericum perforatum (St. John's wort) oil in the prevention of stricture due to esophageal corrosive ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-11

AUTHORS

Mustafa Alper Akay, Mustafa Akduman, Ahmet Çağrı Tataroğlu, Ceyla Eraldemir, Tuğba Kum, Çiğdem Vural, Gülşen Ekingen Yıldız

ABSTRACT

BACKGROUND/PURPOSE: The inflammatory response that follows the caustic burns results in fibrosis on the esophageal wall leading to esophageal stricture, dysphagia, and malnutrition. The controversy over the use of corticosteroids warrants alternative therapeutic interventions. We investigated the effect of extracts from St. John's wort (SJW) with known wound-healing activity on stricture formation in rat esophageal injury models. METHODS: Five experimental groups were involved: sham group with no injury, control group with injury without treatment, and three different treatment groups (methylprednisolone, SJW extract, and combination of the two). Histopathological examination of esophageal damage and collagen accumulation, stenosis index, and tissue hydroxyproline levels were used to assess stricture and the effect of treatments. RESULTS: There was a significant weight loss in all groups except for those without injury and those treated with SJW extract, the latter gained weight albeit not significant. Stenosis index was increased in all groups compared to sham but not significantly in those treated with SJW extract. Histopathological and biochemical analyses produced mixed results. CONCLUSIONS: Some of the experimental indicators such as weight gain and stenosis index suggested the treatment of esophageal injury models using extracts of St. John's wort effective while other histopathological indicators show no significant benefit. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10388-019-00671-2

DOI

http://dx.doi.org/10.1007/s10388-019-00671-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113378555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30976959


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Kocaeli", 
          "id": "https://www.grid.ac/institutes/grid.411105.0", 
          "name": [
            "Department of Pediatric Surgery, Kocaeli University Medical Faculty, Umuttepe, 41380, Kocaeli, Turkey. pedcerr@gmail.com."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akay", 
        "givenName": "Mustafa Alper", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Republic of Turkey Ministry of Health", 
          "id": "https://www.grid.ac/institutes/grid.438866.7", 
          "name": [
            "Republic of Turkey Ministry of Health, Ankara, Turkey."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akduman", 
        "givenName": "Mustafa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Republic of Turkey Ministry of Health", 
          "id": "https://www.grid.ac/institutes/grid.438866.7", 
          "name": [
            "Republic of Turkey Ministry of Health, Ankara, Turkey."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tataro\u011flu", 
        "givenName": "Ahmet \u00c7a\u011fr\u0131", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kocaeli", 
          "id": "https://www.grid.ac/institutes/grid.411105.0", 
          "name": [
            "Department of Biochemistry, Kocaeli University Medical Faculty, Kocaeli, Turkey."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eraldemir", 
        "givenName": "Ceyla", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Republic of Turkey Ministry of Health", 
          "id": "https://www.grid.ac/institutes/grid.438866.7", 
          "name": [
            "Republic of Turkey Ministry of Health, Ankara, Turkey."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kum", 
        "givenName": "Tu\u011fba", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kocaeli", 
          "id": "https://www.grid.ac/institutes/grid.411105.0", 
          "name": [
            "Department of Pathology, Kocaeli University Medical Faculty, Kocaeli, Turkey."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vural", 
        "givenName": "\u00c7i\u011fdem", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kocaeli", 
          "id": "https://www.grid.ac/institutes/grid.411105.0", 
          "name": [
            "Department of Pediatric Surgery, Kocaeli University Medical Faculty, Umuttepe, 41380, Kocaeli, Turkey."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Y\u0131ld\u0131z", 
        "givenName": "G\u00fcl\u015fen Ekingen", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/9781444346220.ch40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000056260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-4975(10)62769-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002645541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13017-015-0043-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003773608", 
          "https://doi.org/10.1186/s13017-015-0043-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(89)90641-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005376031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800810325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006875020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijporl.2005.05.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008582914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.1981.00790390011004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009979957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1749-8090-4-56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013179605", 
          "https://doi.org/10.1186/1749-8090-4-56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjsurg.2003.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017691820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2004.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019408508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348948509400513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022940457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348948509400513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022940457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000225376.83670.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023519425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000225376.83670.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023519425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000225376.83670.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023519425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0102-86502013000200009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024088032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00139709-200524020-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025549500", 
          "https://doi.org/10.2165/00139709-200524020-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00139709-200524020-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025549500", 
          "https://doi.org/10.2165/00139709-200524020-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jpsu.2001.27032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025830445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0972-5229.171377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026287871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0972-5229.171377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026287871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11938-001-0047-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026379021", 
          "https://doi.org/10.1007/s11938-001-0047-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpedsurg.2008.01.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026678309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00383-014-3642-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028276980", 
          "https://doi.org/10.1007/s00383-014-3642-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199009063231004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028517845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13017-015-0039-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028667291", 
          "https://doi.org/10.1186/s13017-015-0039-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-6757(92)90067-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029599948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9781444346220.ch28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033138204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2458-10-83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033811643", 
          "https://doi.org/10.1186/1471-2458-10-83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2004.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037388938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2009.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038876243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2008.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039199362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15563650701285420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043052541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.34.11.1498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047487759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpedsurg.2004.11.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048486436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0022215100135716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048716511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2013-3331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050782743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1211/0022357011775910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052661330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(99)00214-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053164187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0034-1394504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057328291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2003-43581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057425844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/acm.2009.0317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059218774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074468296", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076771523", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5505/tjtes.2015.", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079152513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080611985", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4174/astr.2017.92.6.396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085747211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/wound.2017.0746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091450424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2017.01639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091503100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40124-018-0156-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100695513", 
          "https://doi.org/10.1007/s40124-018-0156-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-11", 
    "datePublishedReg": "2019-04-11", 
    "description": "BACKGROUND/PURPOSE: The inflammatory response that follows the caustic burns results in fibrosis on the esophageal wall leading to esophageal stricture, dysphagia, and malnutrition. The controversy over the use of corticosteroids warrants alternative therapeutic interventions. We investigated the effect of extracts from St. John's wort (SJW) with known wound-healing activity on stricture formation in rat esophageal injury models.\nMETHODS: Five experimental groups were involved: sham group with no injury, control group with injury without treatment, and three different treatment groups (methylprednisolone, SJW extract, and combination of the two). Histopathological examination of esophageal damage and collagen accumulation, stenosis index, and tissue hydroxyproline levels were used to assess stricture and the effect of treatments.\nRESULTS: There was a significant weight loss in all groups except for those without injury and those treated with SJW extract, the latter gained weight albeit not significant. Stenosis index was increased in all groups compared to sham but not significantly in those treated with SJW extract. Histopathological and biochemical analyses produced mixed results.\nCONCLUSIONS: Some of the experimental indicators such as weight gain and stenosis index suggested the treatment of esophageal injury models using extracts of St. John's wort effective while other histopathological indicators show no significant benefit.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10388-019-00671-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1033355", 
        "issn": [
          "1612-9059", 
          "1612-9067"
        ], 
        "name": "Esophagus", 
        "type": "Periodical"
      }
    ], 
    "name": "Evaluation of the efficacy of Hypericum perforatum (St. John's wort) oil in the prevention of stricture due to esophageal corrosive burns.", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10388-019-00671-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113378555"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101206627"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30976959"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10388-019-00671-2", 
      "https://app.dimensions.ai/details/publication/pub.1113378555"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106842_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10388-019-00671-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10388-019-00671-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10388-019-00671-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10388-019-00671-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10388-019-00671-2'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      20 PREDICATES      69 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10388-019-00671-2 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nd23ebddbfb934726a4aa035953228815
4 schema:citation sg:pub.10.1007/s00383-014-3642-3
5 sg:pub.10.1007/s11938-001-0047-x
6 sg:pub.10.1007/s40124-018-0156-9
7 sg:pub.10.1186/1471-2458-10-83
8 sg:pub.10.1186/1749-8090-4-56
9 sg:pub.10.1186/s13017-015-0039-0
10 sg:pub.10.1186/s13017-015-0043-4
11 sg:pub.10.2165/00139709-200524020-00006
12 https://app.dimensions.ai/details/publication/pub.1074468296
13 https://app.dimensions.ai/details/publication/pub.1076771523
14 https://app.dimensions.ai/details/publication/pub.1080611985
15 https://doi.org/10.1001/archotol.1981.00790390011004
16 https://doi.org/10.1002/9781444346220.ch28
17 https://doi.org/10.1002/9781444346220.ch40
18 https://doi.org/10.1002/bjs.1800810325
19 https://doi.org/10.1016/0016-5085(89)90641-0
20 https://doi.org/10.1016/0735-6757(92)90067-8
21 https://doi.org/10.1016/j.amjsurg.2003.11.008
22 https://doi.org/10.1016/j.ijporl.2005.05.018
23 https://doi.org/10.1016/j.jep.2009.10.011
24 https://doi.org/10.1016/j.jpedsurg.2004.11.036
25 https://doi.org/10.1016/j.jpedsurg.2008.01.064
26 https://doi.org/10.1016/j.jss.2004.08.009
27 https://doi.org/10.1016/j.lfs.2004.05.001
28 https://doi.org/10.1016/j.surg.2008.10.007
29 https://doi.org/10.1016/s0003-4975(10)62769-5
30 https://doi.org/10.1016/s0140-6736(99)00214-7
31 https://doi.org/10.1017/s0022215100135716
32 https://doi.org/10.1053/jpsu.2001.27032
33 https://doi.org/10.1055/s-0034-1394504
34 https://doi.org/10.1055/s-2003-43581
35 https://doi.org/10.1056/nejm199009063231004
36 https://doi.org/10.1080/15563650701285420
37 https://doi.org/10.1089/acm.2009.0317
38 https://doi.org/10.1089/wound.2017.0746
39 https://doi.org/10.1097/01.mlg.0000225376.83670.4d
40 https://doi.org/10.1136/gut.34.11.1498
41 https://doi.org/10.1177/000348948509400513
42 https://doi.org/10.1211/0022357011775910
43 https://doi.org/10.1542/peds.2013-3331
44 https://doi.org/10.1590/s0102-86502013000200009
45 https://doi.org/10.3389/fmicb.2017.01639
46 https://doi.org/10.4103/0972-5229.171377
47 https://doi.org/10.4174/astr.2017.92.6.396
48 https://doi.org/10.5505/tjtes.2015.
49 schema:datePublished 2019-04-11
50 schema:datePublishedReg 2019-04-11
51 schema:description BACKGROUND/PURPOSE: The inflammatory response that follows the caustic burns results in fibrosis on the esophageal wall leading to esophageal stricture, dysphagia, and malnutrition. The controversy over the use of corticosteroids warrants alternative therapeutic interventions. We investigated the effect of extracts from St. John's wort (SJW) with known wound-healing activity on stricture formation in rat esophageal injury models. METHODS: Five experimental groups were involved: sham group with no injury, control group with injury without treatment, and three different treatment groups (methylprednisolone, SJW extract, and combination of the two). Histopathological examination of esophageal damage and collagen accumulation, stenosis index, and tissue hydroxyproline levels were used to assess stricture and the effect of treatments. RESULTS: There was a significant weight loss in all groups except for those without injury and those treated with SJW extract, the latter gained weight albeit not significant. Stenosis index was increased in all groups compared to sham but not significantly in those treated with SJW extract. Histopathological and biochemical analyses produced mixed results. CONCLUSIONS: Some of the experimental indicators such as weight gain and stenosis index suggested the treatment of esophageal injury models using extracts of St. John's wort effective while other histopathological indicators show no significant benefit.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf sg:journal.1033355
56 schema:name Evaluation of the efficacy of Hypericum perforatum (St. John's wort) oil in the prevention of stricture due to esophageal corrosive burns.
57 schema:productId N26ead405b9464537a5000f4c2377abf8
58 N4ac7496e05a74e4cadf2013c6619f082
59 N9fb6047cc6d64e3a9f65051eab2803e2
60 Nf45e883bcf0b4efbbf817ef03bf1afb3
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113378555
62 https://doi.org/10.1007/s10388-019-00671-2
63 schema:sdDatePublished 2019-04-16T06:26
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Ne612c78fe4884c4eb3a993de8fe54030
66 schema:url http://link.springer.com/10.1007/s10388-019-00671-2
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N1363625b5b1f4678a00edf1e1fe16c24 rdf:first Nac224e79d45447768cb2dbe9fbeec94c
71 rdf:rest rdf:nil
72 N26ead405b9464537a5000f4c2377abf8 schema:name doi
73 schema:value 10.1007/s10388-019-00671-2
74 rdf:type schema:PropertyValue
75 N37727d6c1bbd46ef81663bc20c531a74 schema:affiliation https://www.grid.ac/institutes/grid.411105.0
76 schema:familyName Eraldemir
77 schema:givenName Ceyla
78 rdf:type schema:Person
79 N42f3374861054e8dbcebbc045d434f9f schema:affiliation https://www.grid.ac/institutes/grid.438866.7
80 schema:familyName Kum
81 schema:givenName Tuğba
82 rdf:type schema:Person
83 N4ac7496e05a74e4cadf2013c6619f082 schema:name pubmed_id
84 schema:value 30976959
85 rdf:type schema:PropertyValue
86 N4b6a1951e3b2444b9f41cbafb5daee14 rdf:first N42f3374861054e8dbcebbc045d434f9f
87 rdf:rest N5fba335532964c958497b97ec86c2969
88 N4fc72e49685e4c73a021d0164ed695d5 schema:affiliation https://www.grid.ac/institutes/grid.411105.0
89 schema:familyName Akay
90 schema:givenName Mustafa Alper
91 rdf:type schema:Person
92 N5fba335532964c958497b97ec86c2969 rdf:first N9b7c0167163540e9bb07e5d036da9c3d
93 rdf:rest N1363625b5b1f4678a00edf1e1fe16c24
94 N8e0db9dcf5ec4e9ba868ad518432ade8 rdf:first Nbf992639102e4195ade47b6895b55452
95 rdf:rest Ne4ec672067b948ae85562f319bea8eed
96 N9b7c0167163540e9bb07e5d036da9c3d schema:affiliation https://www.grid.ac/institutes/grid.411105.0
97 schema:familyName Vural
98 schema:givenName Çiğdem
99 rdf:type schema:Person
100 N9fb6047cc6d64e3a9f65051eab2803e2 schema:name dimensions_id
101 schema:value pub.1113378555
102 rdf:type schema:PropertyValue
103 Na6305038adfb486a88b32c17c584317e schema:affiliation https://www.grid.ac/institutes/grid.438866.7
104 schema:familyName Tataroğlu
105 schema:givenName Ahmet Çağrı
106 rdf:type schema:Person
107 Nac224e79d45447768cb2dbe9fbeec94c schema:affiliation https://www.grid.ac/institutes/grid.411105.0
108 schema:familyName Yıldız
109 schema:givenName Gülşen Ekingen
110 rdf:type schema:Person
111 Nbf992639102e4195ade47b6895b55452 schema:affiliation https://www.grid.ac/institutes/grid.438866.7
112 schema:familyName Akduman
113 schema:givenName Mustafa
114 rdf:type schema:Person
115 Nd23ebddbfb934726a4aa035953228815 rdf:first N4fc72e49685e4c73a021d0164ed695d5
116 rdf:rest N8e0db9dcf5ec4e9ba868ad518432ade8
117 Ne4ec672067b948ae85562f319bea8eed rdf:first Na6305038adfb486a88b32c17c584317e
118 rdf:rest Nf32cc29ba387422b884f37b837522600
119 Ne612c78fe4884c4eb3a993de8fe54030 schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 Nf32cc29ba387422b884f37b837522600 rdf:first N37727d6c1bbd46ef81663bc20c531a74
122 rdf:rest N4b6a1951e3b2444b9f41cbafb5daee14
123 Nf45e883bcf0b4efbbf817ef03bf1afb3 schema:name nlm_unique_id
124 schema:value 101206627
125 rdf:type schema:PropertyValue
126 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
127 schema:name Medical and Health Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
130 schema:name Clinical Sciences
131 rdf:type schema:DefinedTerm
132 sg:journal.1033355 schema:issn 1612-9059
133 1612-9067
134 schema:name Esophagus
135 rdf:type schema:Periodical
136 sg:pub.10.1007/s00383-014-3642-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028276980
137 https://doi.org/10.1007/s00383-014-3642-3
138 rdf:type schema:CreativeWork
139 sg:pub.10.1007/s11938-001-0047-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026379021
140 https://doi.org/10.1007/s11938-001-0047-x
141 rdf:type schema:CreativeWork
142 sg:pub.10.1007/s40124-018-0156-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100695513
143 https://doi.org/10.1007/s40124-018-0156-9
144 rdf:type schema:CreativeWork
145 sg:pub.10.1186/1471-2458-10-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033811643
146 https://doi.org/10.1186/1471-2458-10-83
147 rdf:type schema:CreativeWork
148 sg:pub.10.1186/1749-8090-4-56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013179605
149 https://doi.org/10.1186/1749-8090-4-56
150 rdf:type schema:CreativeWork
151 sg:pub.10.1186/s13017-015-0039-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028667291
152 https://doi.org/10.1186/s13017-015-0039-0
153 rdf:type schema:CreativeWork
154 sg:pub.10.1186/s13017-015-0043-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003773608
155 https://doi.org/10.1186/s13017-015-0043-4
156 rdf:type schema:CreativeWork
157 sg:pub.10.2165/00139709-200524020-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025549500
158 https://doi.org/10.2165/00139709-200524020-00006
159 rdf:type schema:CreativeWork
160 https://app.dimensions.ai/details/publication/pub.1074468296 schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1076771523 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1080611985 schema:CreativeWork
163 https://doi.org/10.1001/archotol.1981.00790390011004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009979957
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1002/9781444346220.ch28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033138204
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1002/9781444346220.ch40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000056260
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1002/bjs.1800810325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006875020
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/0016-5085(89)90641-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005376031
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/0735-6757(92)90067-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029599948
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.amjsurg.2003.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017691820
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.ijporl.2005.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008582914
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.jep.2009.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038876243
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.jpedsurg.2004.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048486436
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.jpedsurg.2008.01.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026678309
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.jss.2004.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037388938
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.lfs.2004.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019408508
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.surg.2008.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039199362
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/s0003-4975(10)62769-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002645541
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0140-6736(99)00214-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053164187
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1017/s0022215100135716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048716511
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1053/jpsu.2001.27032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025830445
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1055/s-0034-1394504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057328291
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1055/s-2003-43581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057425844
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1056/nejm199009063231004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028517845
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1080/15563650701285420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043052541
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1089/acm.2009.0317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059218774
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1089/wound.2017.0746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091450424
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1097/01.mlg.0000225376.83670.4d schema:sameAs https://app.dimensions.ai/details/publication/pub.1023519425
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1136/gut.34.11.1498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047487759
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1177/000348948509400513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022940457
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1211/0022357011775910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052661330
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1542/peds.2013-3331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050782743
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1590/s0102-86502013000200009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024088032
222 rdf:type schema:CreativeWork
223 https://doi.org/10.3389/fmicb.2017.01639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091503100
224 rdf:type schema:CreativeWork
225 https://doi.org/10.4103/0972-5229.171377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026287871
226 rdf:type schema:CreativeWork
227 https://doi.org/10.4174/astr.2017.92.6.396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085747211
228 rdf:type schema:CreativeWork
229 https://doi.org/10.5505/tjtes.2015. schema:sameAs https://app.dimensions.ai/details/publication/pub.1079152513
230 rdf:type schema:CreativeWork
231 https://www.grid.ac/institutes/grid.411105.0 schema:alternateName University of Kocaeli
232 schema:name Department of Biochemistry, Kocaeli University Medical Faculty, Kocaeli, Turkey.
233 Department of Pathology, Kocaeli University Medical Faculty, Kocaeli, Turkey.
234 Department of Pediatric Surgery, Kocaeli University Medical Faculty, Umuttepe, 41380, Kocaeli, Turkey.
235 Department of Pediatric Surgery, Kocaeli University Medical Faculty, Umuttepe, 41380, Kocaeli, Turkey. pedcerr@gmail.com.
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.438866.7 schema:alternateName Republic of Turkey Ministry of Health
238 schema:name Republic of Turkey Ministry of Health, Ankara, Turkey.
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...