Tumor blood flow change measured by CT perfusion during chemoradiation therapy (CRT) for monitoring response and predicting survival in patients ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01

AUTHORS

Koichi Hayano, Kiyohiko Shuto, Asami Satoh, Tomoyoshi Aoyagi, Kazuo Narushima, Hisashi Gunji, Tsuguaki Kono, Noriyuki Yanagawa, Shinichi Okazumi, Hisahiro Matsubara

ABSTRACT

The purpose of this study is to evaluate whether computed tomography perfusion (CTP) can evaluate the biological change during chemoradiation therapy (CRT) and the survival of patients with esophageal cancer after CRT. Thirty-two consecutive patients (31 men, 1 woman; mean age 65.9 years) with esophageal squamous cell carcinoma underwent CTP before and 2–3 weeks after CRT. The perfusion data were analyzed using software based on the deconvolution method. We investigated the relationship between the changes of CTP parameters during CRT, the response to CRT and outcome. This study included 22 clinical responders and 10 non-responders. Post-CRT blood flow (BF) was significantly lower than pre-CRT (P = 0.0003). BF in responders decreased significantly greater than in non-responders (P < 0.0001). Patients whose tumors showed a greater reduction (greater than 15 % reduction) in BF during CRT survived significantly longer than those with lower tumor BF reduction (P = 0.03). Substantial BF change may help to evaluate the response to CRT and survival in patients with advanced esophageal squamous cell carcinoma. More... »

PAGES

72-79

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10388-013-0400-x

DOI

http://dx.doi.org/10.1007/s10388-013-0400-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023358293


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39 schema:description The purpose of this study is to evaluate whether computed tomography perfusion (CTP) can evaluate the biological change during chemoradiation therapy (CRT) and the survival of patients with esophageal cancer after CRT. Thirty-two consecutive patients (31 men, 1 woman; mean age 65.9 years) with esophageal squamous cell carcinoma underwent CTP before and 2–3 weeks after CRT. The perfusion data were analyzed using software based on the deconvolution method. We investigated the relationship between the changes of CTP parameters during CRT, the response to CRT and outcome. This study included 22 clinical responders and 10 non-responders. Post-CRT blood flow (BF) was significantly lower than pre-CRT (P = 0.0003). BF in responders decreased significantly greater than in non-responders (P < 0.0001). Patients whose tumors showed a greater reduction (greater than 15 % reduction) in BF during CRT survived significantly longer than those with lower tumor BF reduction (P = 0.03). Substantial BF change may help to evaluate the response to CRT and survival in patients with advanced esophageal squamous cell carcinoma.
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