A multicenter clinical trial of orthokeratology in school-aged children and adolescents in Japan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-05-29

AUTHORS

Tomoko Goto, Atsushi Shiraishi, Yuichi Ohashi, Kazuno Negishi, Kazuo Tsubota, Yo Nakamura, Osamu Hieda, Chie Sotozono, Shigeru Kinoshita

ABSTRACT

PurposeThis study investigated the safety and efficacy of orthokeratology in myopic children in Japan.Study designProspective clinical trial.MethodsThis study enrolled myopic children aged 6–16 years with a spherical equivalent of −1.00 D to −4.00 D and astigmatism of −1.5 D or lower, whose parents could manage contact lens use and could provide written informed consent. The children were treated with orthokeratology lenses (BREATH-O CORRECT R, Universal View Co., Ltd.) for 3 years. Slit-lamp findings, visual acuity, intraocular pressure, subjective refraction, corneal topography, corneal endothelial cell density, corneal thickness, and axial length were regularly assessed.ResultsThis study included 96 eyes of 48 patients (average age, 10.7 ± 2.08 years). The average baseline spherical equivalent was −2.46 ± 0.97 D. The average baseline uncorrected visual acuity was 0.74 ± 0.32 logMAR, with significant improvement to −0.08 ± 0.18 logMAR at 4 weeks and 0.02 ± 0.21 logMAR at 3 years (both p < 0.001, Dunnett’s test). The average baseline corneal endothelial cell density was 3053 ± 181 cells/mm2 and 3028 ± 213 cells/mm2 at postoperative 3 years (p = 0.9933, Dunnett’s test). The average axial length was 24.70 ± 0.78 mm at baseline, 24.77 ± 0.80 mm at 12 weeks, and 25.32 ± 0.85 mm at 36 months. Although mild corneal epithelial disorders occurred in 18% of eyes, they were successfully treated with eye drops, enabling resumption of lens usage. No serious adverse events were observed.ConclusionOrthokeratology lens (BREATH-O CORRECT R) use in children demonstrated good efficacy and safety during 3 years of follow-up. More... »

PAGES

624-631

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10384-021-00842-8

DOI

http://dx.doi.org/10.1007/s10384-021-00842-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138463823

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34050849


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