Ontology type: schema:ScholarlyArticle
2021-02-14
AUTHORSOsamu Hieda, Takahiro Hiraoka, Takashi Fujikado, Satoshi Ishiko, Satoshi Hasebe, Hidemasa Torii, Hiroshi Takahashi, Yo Nakamura, Chie Sotozono, Tetsuro Oshika, Takeshi Morimoto, Kohji Nishida, Noriko Nishikawa, Young-Seok Song, Tomoki Tokutake, Yasuyo Nishi, Yuta Shigeno, Toshihide Kurihara, Kazuno Negishi, Kazuo Tsubota, Masafumi Ono, Tomoko Nakai, Donald Tan, Shiro Tanaka, Shigeru Kinoshita
ABSTRACTPurposeAtropine eye drops prevent the progression of myopia, but their use has not been tested in the Japanese schoolchildren population. Here, we evaluate the efficacy and safety of 0.01% atropine eye drops for myopia control in Japanese children.Study designMulticenter (7 university hospitals), randomized, double-masked, placebo-controlled trial.MethodsParticipants were 171 Japanese schoolchildren aged 6 to 12 years, with progressive myopia, spherical equivalence (SE) of −1.00 to −6.00 diopters (D), and astigmatism of ≤1.5 D. They were randomized to receive either 0.01% atropine (n=85) or placebo (n=86) eye drops once nightly OU for 24 months. Primary and secondary efficacy endpoints were changes in SE and axial length (AL), respectively, from baseline to month 24.ResultsData from 168 subjects were analyzed. At month 24, compliance was similar in both groups (atropine: 83.3%; placebo: 85.7%). The least squares mean change in SE and AL from baseline were, respectively, −1.26 D (95% confidence interval [CI]: −1.35, −1.17) and 0.63 mm (0.59, 0.67) for atropine and −1.48 D (− 1.57, −1.39) and 0.77 mm (0.73, 0.81) for placebo. Inter-group differences were 0.22 D (95% CI: 0.09, 0.35; P < 0.001) for SE and − 0.14 mm (−0.20, −0.08; P < 0.001) for AL. Three patients experienced mild allergic conjunctivitis side effects, with no inter-group difference in incidence (atropine: 2.4%; 2/84 patients; placebo: 1.4%; 1/84 patients).ConclusionWith good compliance, 0.01% atropine is effective and safe for preventing the progression of childhood myopia. More... »
PAGES315-325
http://scigraph.springernature.com/pub.10.1007/s10384-021-00822-y
DOIhttp://dx.doi.org/10.1007/s10384-021-00822-y
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33586090
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10384-021-00822-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10384-021-00822-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10384-021-00822-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10384-021-00822-y'
This table displays all metadata directly associated to this object as RDF triples.
358 TRIPLES
21 PREDICATES
90 URIs
81 LITERALS
16 BLANK NODES