Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-02-14

AUTHORS

Osamu Hieda, Takahiro Hiraoka, Takashi Fujikado, Satoshi Ishiko, Satoshi Hasebe, Hidemasa Torii, Hiroshi Takahashi, Yo Nakamura, Chie Sotozono, Tetsuro Oshika, Takeshi Morimoto, Kohji Nishida, Noriko Nishikawa, Young-Seok Song, Tomoki Tokutake, Yasuyo Nishi, Yuta Shigeno, Toshihide Kurihara, Kazuno Negishi, Kazuo Tsubota, Masafumi Ono, Tomoko Nakai, Donald Tan, Shiro Tanaka, Shigeru Kinoshita

ABSTRACT

PurposeAtropine eye drops prevent the progression of myopia, but their use has not been tested in the Japanese schoolchildren population. Here, we evaluate the efficacy and safety of 0.01% atropine eye drops for myopia control in Japanese children.Study designMulticenter (7 university hospitals), randomized, double-masked, placebo-controlled trial.MethodsParticipants were 171 Japanese schoolchildren aged 6 to 12 years, with progressive myopia, spherical equivalence (SE) of −1.00 to −6.00 diopters (D), and astigmatism of ≤1.5 D. They were randomized to receive either 0.01% atropine (n=85) or placebo (n=86) eye drops once nightly OU for 24 months. Primary and secondary efficacy endpoints were changes in SE and axial length (AL), respectively, from baseline to month 24.ResultsData from 168 subjects were analyzed. At month 24, compliance was similar in both groups (atropine: 83.3%; placebo: 85.7%). The least squares mean change in SE and AL from baseline were, respectively, −1.26 D (95% confidence interval [CI]: −1.35, −1.17) and 0.63 mm (0.59, 0.67) for atropine and −1.48 D (− 1.57, −1.39) and 0.77 mm (0.73, 0.81) for placebo. Inter-group differences were 0.22 D (95% CI: 0.09, 0.35; P < 0.001) for SE and − 0.14 mm (−0.20, −0.08; P < 0.001) for AL. Three patients experienced mild allergic conjunctivitis side effects, with no inter-group difference in incidence (atropine: 2.4%; 2/84 patients; placebo: 1.4%; 1/84 patients).ConclusionWith good compliance, 0.01% atropine is effective and safe for preventing the progression of childhood myopia. More... »

PAGES

315-325

References to SciGraph publications

Journal

TITLE

Japanese Journal of Ophthalmology

ISSUE

3

VOLUME

65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10384-021-00822-y

DOI

http://dx.doi.org/10.1007/s10384-021-00822-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1135368148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33586090


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343 grid-institutes:grid.272458.e schema:alternateName Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, 602-0841, Kyoto, Kyoto, Japan
344 Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan
345 schema:name Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, 602-0841, Kyoto, Kyoto, Japan
346 Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan
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348 grid-institutes:grid.410821.e schema:alternateName Department of Ophthalmology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
349 schema:name Department of Ophthalmology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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351 grid-institutes:grid.415086.e schema:alternateName Department of Ophthalmology 2, Kawasaki Medical School, Kurashiki, Okayama, Japan
352 Department of Ophthalmology, Kawasaki Medical School General Medical Center, Okayama, Okayama, Japan
353 schema:name Department of Ophthalmology 2, Kawasaki Medical School, Kurashiki, Okayama, Japan
354 Department of Ophthalmology, Kawasaki Medical School General Medical Center, Okayama, Okayama, Japan
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356 grid-institutes:grid.419272.b schema:alternateName Singapore National Eye Centre, Singapore, Singapore
357 schema:name Singapore National Eye Centre, Singapore, Singapore
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