Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09

AUTHORS

Ken Asakawa, Hitoshi Ishikawa, Shigekazu Uga, Kimiyo Mashimo, Kimiya Shimizu, Mineo Kondo, Hiroko Terasaki

ABSTRACT

PURPOSE: To investigate the process of retinal degeneration by analyzing the functional and morphological findings in transgenic rabbits with a Pro347Leu rhodopsin mutation. METHODS: Wild-type (WT) and transgenic (Tg) rabbits at ages 4, 8 and 12 months were used. We conducted functional evaluation by recording the changes in the pupil response to red and blue light stimulation and the amplitude of the electroretinography (ERG). Morphologically, rod and cone distribution was examined using light and electron microscopy. Immunostaining for the identification of retinal ganglion cells (RGCs) was also confirmed by injecting a TUJ-1 monoclonal antibody. RESULTS: Pupil constriction for infrared pupillography and the a- and b-waves for ERG in Tg rabbits decreased with increasing age; the differences were compared to the age-matched WT rabbits. The subnormal ERG in the Tg rabbits, especially the a-wave decrease and pupil constriction with a long latency time, was induced only during exposure to blue light stimulation at 12 months. Light and electron microscopic findings showed a progressive loss of photoreceptor cells over time manifesting by 8 months in the peripheral retina. Moreover, pyknotic nuclei of the outer nuclear layer in the center of the visual streak were observed. At 12 months, there was disappearance of the rods and ballooning degeneration of the cones. Some remaining RGCs had large cell bodies with long branching dendrites. CONCLUSIONS: The changes in the pupil light response and amplitude of the ERG could be used to predict the state of retinal degeneration in the Tg rabbit. More... »

PAGES

353-363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10384-015-0400-6

DOI

http://dx.doi.org/10.1007/s10384-015-0400-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033603431

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26245743


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electroretinography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Light", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photoreceptor Cells, Vertebrate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Point Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pupil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reflex, Pupillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Ganglion Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinitis Pigmentosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rhodopsin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tubulin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kitasato University", 
          "id": "https://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Orthoptics and Visual Science, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, 252-0373, Sagamihara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asakawa", 
        "givenName": "Ken", 
        "id": "sg:person.0606677062.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606677062.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kitasato University", 
          "id": "https://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Orthoptics and Visual Science, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, 252-0373, Sagamihara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishikawa", 
        "givenName": "Hitoshi", 
        "id": "sg:person.01116406051.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116406051.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kitasato University", 
          "id": "https://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Orthoptics and Visual Science, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, 252-0373, Sagamihara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uga", 
        "givenName": "Shigekazu", 
        "id": "sg:person.0772164322.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772164322.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kitasato University", 
          "id": "https://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mashimo", 
        "givenName": "Kimiyo", 
        "id": "sg:person.0617516171.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617516171.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kitasato University", 
          "id": "https://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimizu", 
        "givenName": "Kimiya", 
        "id": "sg:person.01173355062.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173355062.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Ophthalmology, Mie University Graduate School, School of Medicine, Mie, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondo", 
        "givenName": "Mineo", 
        "id": "sg:person.013003065207.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013003065207.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Ophthalmology, Nagoya University Graduate School, School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terasaki", 
        "givenName": "Hiroko", 
        "id": "sg:person.0716560561.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716560561.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.visres.2013.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002027133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.11-7611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003983215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.08-2863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008252881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10384-012-0147-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008837420", 
          "https://doi.org/10.1007/s10384-012-0147-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2006.07.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010206693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9394(14)73708-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013318572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.11-9067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013552072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.1992.01080230134038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016537440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0952523800006799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017226065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10384-010-0842-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021100932", 
          "https://doi.org/10.1007/s10384-010-0842-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10384-010-0842-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021100932", 
          "https://doi.org/10.1007/s10384-010-0842-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.65.1.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022864598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.072557799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022869578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024154404", 
          "https://doi.org/10.1038/88443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024154404", 
          "https://doi.org/10.1038/88443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.17.1.208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024183842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.07-0032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025154074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.09-3458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029767543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.11-9006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030520626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6989(85)90056-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032519798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6989(85)90056-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032519798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.22703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035297158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0036135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037238637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10384-011-0116-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039132512", 
          "https://doi.org/10.1007/s10384-011-0116-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00236786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039923802", 
          "https://doi.org/10.1007/bf00236786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00236786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039923802", 
          "https://doi.org/10.1007/bf00236786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.24.14176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045812488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02157769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048079189", 
          "https://doi.org/10.1007/bf02157769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-008-9155-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048157101", 
          "https://doi.org/10.1007/s10633-008-9155-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00142525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049085077", 
          "https://doi.org/10.1007/bf00142525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00142525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049085077", 
          "https://doi.org/10.1007/bf00142525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/80639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049247362", 
          "https://doi.org/10.1038/80639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/80639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049247362", 
          "https://doi.org/10.1038/80639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)69740-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050875870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.101.2635.653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062442384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7824934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.20-02-00600.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074575276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074692377", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074775232", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074860868", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077172579", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1991.71.2.447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078033004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082583480", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082662864", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082821292", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09", 
    "datePublishedReg": "2015-09-01", 
    "description": "PURPOSE: To investigate the process of retinal degeneration by analyzing the functional and morphological findings in transgenic rabbits with a Pro347Leu rhodopsin mutation.\nMETHODS: Wild-type (WT) and transgenic (Tg) rabbits at ages 4, 8 and 12 months were used. We conducted functional evaluation by recording the changes in the pupil response to red and blue light stimulation and the amplitude of the electroretinography (ERG). Morphologically, rod and cone distribution was examined using light and electron microscopy. Immunostaining for the identification of retinal ganglion cells (RGCs) was also confirmed by injecting a TUJ-1 monoclonal antibody.\nRESULTS: Pupil constriction for infrared pupillography and the a- and b-waves for ERG in Tg rabbits decreased with increasing age; the differences were compared to the age-matched WT rabbits. The subnormal ERG in the Tg rabbits, especially the a-wave decrease and pupil constriction with a long latency time, was induced only during exposure to blue light stimulation at 12 months. Light and electron microscopic findings showed a progressive loss of photoreceptor cells over time manifesting by 8 months in the peripheral retina. Moreover, pyknotic nuclei of the outer nuclear layer in the center of the visual streak were observed. At 12 months, there was disappearance of the rods and ballooning degeneration of the cones. Some remaining RGCs had large cell bodies with long branching dendrites.\nCONCLUSIONS: The changes in the pupil light response and amplitude of the ERG could be used to predict the state of retinal degeneration in the Tg rabbit.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10384-015-0400-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5859216", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6153804", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1005673", 
        "issn": [
          "0021-5155", 
          "1613-2246"
        ], 
        "name": "Japanese Journal of Ophthalmology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "59"
      }
    ], 
    "name": "Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation", 
    "pagination": "353-363", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a01351a7bead671b979ccb13ea87125108e2a8c9c0a1c2f0487cb6ec1c7fba62"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26245743"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0044652"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10384-015-0400-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033603431"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10384-015-0400-6", 
      "https://app.dimensions.ai/details/publication/pub.1033603431"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000489.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10384-015-0400-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10384-015-0400-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10384-015-0400-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10384-015-0400-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10384-015-0400-6'


 

This table displays all metadata directly associated to this object as RDF triples.

296 TRIPLES      21 PREDICATES      82 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10384-015-0400-6 schema:about N117d84b9e62640839d43967a2c8c9b4c
2 N2bb074698ccf40e48f1243834571df28
3 N2c05ec6b22c24b7799ffc480c4bfcfa9
4 N4061ba0b1d56473187894bde32b61ce6
5 N4d1cf191be4546cabd10efdf5f2e257c
6 N944623142b994ffd86f446e57a8db061
7 N946d2a0024284d75a55db1973b8a5f2b
8 N9bbc27a9ce784cadaf5cc3e7ed69b164
9 N9ea67586b11d441087c60ebfd00a1951
10 Na6b87b891e1f4800b999680752701a8b
11 Na737bd9e5316435abb88c9e653fb8b4a
12 Nb043fe0b82c24259976f91e3528a97b4
13 Nbe5d792febae4bee86ff59b049de61cc
14 Nec52791961f3422db8d84d0426b017e5
15 anzsrc-for:11
16 anzsrc-for:1113
17 schema:author N8c64c5adb44b47da99b3869a468c2d1f
18 schema:citation sg:pub.10.1007/bf00142525
19 sg:pub.10.1007/bf00236786
20 sg:pub.10.1007/bf02157769
21 sg:pub.10.1007/s10384-010-0842-9
22 sg:pub.10.1007/s10384-011-0116-1
23 sg:pub.10.1007/s10384-012-0147-2
24 sg:pub.10.1007/s10633-008-9155-4
25 sg:pub.10.1038/80639
26 sg:pub.10.1038/88443
27 https://app.dimensions.ai/details/publication/pub.1074692377
28 https://app.dimensions.ai/details/publication/pub.1074775232
29 https://app.dimensions.ai/details/publication/pub.1074860868
30 https://app.dimensions.ai/details/publication/pub.1077172579
31 https://app.dimensions.ai/details/publication/pub.1082583480
32 https://app.dimensions.ai/details/publication/pub.1082662864
33 https://app.dimensions.ai/details/publication/pub.1082821292
34 https://doi.org/10.1001/archopht.1992.01080230134038
35 https://doi.org/10.1002/cne.22703
36 https://doi.org/10.1016/0042-6989(85)90056-2
37 https://doi.org/10.1016/j.ajo.2006.07.024
38 https://doi.org/10.1016/j.visres.2013.08.006
39 https://doi.org/10.1016/s0002-9394(14)73708-0
40 https://doi.org/10.1016/s0140-6736(06)69740-7
41 https://doi.org/10.1017/s0952523800006799
42 https://doi.org/10.1073/pnas.072557799
43 https://doi.org/10.1073/pnas.93.24.14176
44 https://doi.org/10.1083/jcb.17.1.208
45 https://doi.org/10.1126/science.101.2635.653
46 https://doi.org/10.1126/science.7824934
47 https://doi.org/10.1136/bjo.65.1.23
48 https://doi.org/10.1152/physrev.1991.71.2.447
49 https://doi.org/10.1167/iovs.07-0032
50 https://doi.org/10.1167/iovs.08-2863
51 https://doi.org/10.1167/iovs.09-3458
52 https://doi.org/10.1167/iovs.11-7611
53 https://doi.org/10.1167/iovs.11-9006
54 https://doi.org/10.1167/iovs.11-9067
55 https://doi.org/10.1371/journal.pone.0036135
56 https://doi.org/10.1523/jneurosci.20-02-00600.2000
57 schema:datePublished 2015-09
58 schema:datePublishedReg 2015-09-01
59 schema:description PURPOSE: To investigate the process of retinal degeneration by analyzing the functional and morphological findings in transgenic rabbits with a Pro347Leu rhodopsin mutation. METHODS: Wild-type (WT) and transgenic (Tg) rabbits at ages 4, 8 and 12 months were used. We conducted functional evaluation by recording the changes in the pupil response to red and blue light stimulation and the amplitude of the electroretinography (ERG). Morphologically, rod and cone distribution was examined using light and electron microscopy. Immunostaining for the identification of retinal ganglion cells (RGCs) was also confirmed by injecting a TUJ-1 monoclonal antibody. RESULTS: Pupil constriction for infrared pupillography and the a- and b-waves for ERG in Tg rabbits decreased with increasing age; the differences were compared to the age-matched WT rabbits. The subnormal ERG in the Tg rabbits, especially the a-wave decrease and pupil constriction with a long latency time, was induced only during exposure to blue light stimulation at 12 months. Light and electron microscopic findings showed a progressive loss of photoreceptor cells over time manifesting by 8 months in the peripheral retina. Moreover, pyknotic nuclei of the outer nuclear layer in the center of the visual streak were observed. At 12 months, there was disappearance of the rods and ballooning degeneration of the cones. Some remaining RGCs had large cell bodies with long branching dendrites. CONCLUSIONS: The changes in the pupil light response and amplitude of the ERG could be used to predict the state of retinal degeneration in the Tg rabbit.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N02d6567973a644bf8a9451f810a53f3a
64 N561b10ed18ab4ab584fdd1d430b8d5d0
65 sg:journal.1005673
66 schema:name Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation
67 schema:pagination 353-363
68 schema:productId N0282ffb4cb214974b1907dd00a0a0b5c
69 N2c128d7046164ffaae381adc4b1b128d
70 N57aeab9d0fb64f10957caaee8ce3a127
71 N847326c8e3894f088e760a507d6fc55b
72 N8e3378bf42554bce97c6796477025950
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033603431
74 https://doi.org/10.1007/s10384-015-0400-6
75 schema:sdDatePublished 2019-04-10T19:03
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Nc3016cdfcdaa49a0858dcbe4dd3c23c1
78 schema:url http://link.springer.com/10.1007/s10384-015-0400-6
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N0282ffb4cb214974b1907dd00a0a0b5c schema:name nlm_unique_id
83 schema:value 0044652
84 rdf:type schema:PropertyValue
85 N02d6567973a644bf8a9451f810a53f3a schema:issueNumber 5
86 rdf:type schema:PublicationIssue
87 N117d84b9e62640839d43967a2c8c9b4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Pupil
89 rdf:type schema:DefinedTerm
90 N1dfc8790a9f840908cb098e1200af5ee rdf:first sg:person.013003065207.03
91 rdf:rest Nd1acb3457cca4cf8954660d2a90c2a7e
92 N2bb074698ccf40e48f1243834571df28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Rabbits
94 rdf:type schema:DefinedTerm
95 N2c05ec6b22c24b7799ffc480c4bfcfa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Retinitis Pigmentosa
97 rdf:type schema:DefinedTerm
98 N2c128d7046164ffaae381adc4b1b128d schema:name doi
99 schema:value 10.1007/s10384-015-0400-6
100 rdf:type schema:PropertyValue
101 N30e9bfa9db604853a11edf142a8b4e8b rdf:first sg:person.0617516171.61
102 rdf:rest Nc21e10f7d60142d18c2ae802b849495d
103 N4061ba0b1d56473187894bde32b61ce6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Tubulin
105 rdf:type schema:DefinedTerm
106 N4d1cf191be4546cabd10efdf5f2e257c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Reflex, Pupillary
108 rdf:type schema:DefinedTerm
109 N561b10ed18ab4ab584fdd1d430b8d5d0 schema:volumeNumber 59
110 rdf:type schema:PublicationVolume
111 N57aeab9d0fb64f10957caaee8ce3a127 schema:name readcube_id
112 schema:value a01351a7bead671b979ccb13ea87125108e2a8c9c0a1c2f0487cb6ec1c7fba62
113 rdf:type schema:PropertyValue
114 N713b1ea7e4d04a14a65f7eefc5c5c061 rdf:first sg:person.01116406051.77
115 rdf:rest Nc5644219c0474a30990423fd64754f24
116 N847326c8e3894f088e760a507d6fc55b schema:name pubmed_id
117 schema:value 26245743
118 rdf:type schema:PropertyValue
119 N8c64c5adb44b47da99b3869a468c2d1f rdf:first sg:person.0606677062.99
120 rdf:rest N713b1ea7e4d04a14a65f7eefc5c5c061
121 N8e3378bf42554bce97c6796477025950 schema:name dimensions_id
122 schema:value pub.1033603431
123 rdf:type schema:PropertyValue
124 N944623142b994ffd86f446e57a8db061 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Photoreceptor Cells, Vertebrate
126 rdf:type schema:DefinedTerm
127 N946d2a0024284d75a55db1973b8a5f2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Animals
129 rdf:type schema:DefinedTerm
130 N9bbc27a9ce784cadaf5cc3e7ed69b164 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Light
132 rdf:type schema:DefinedTerm
133 N9ea67586b11d441087c60ebfd00a1951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Disease Models, Animal
135 rdf:type schema:DefinedTerm
136 Na6b87b891e1f4800b999680752701a8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Point Mutation
138 rdf:type schema:DefinedTerm
139 Na737bd9e5316435abb88c9e653fb8b4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Electroretinography
141 rdf:type schema:DefinedTerm
142 Nb043fe0b82c24259976f91e3528a97b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Rhodopsin
144 rdf:type schema:DefinedTerm
145 Nbe5d792febae4bee86ff59b049de61cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Animals, Genetically Modified
147 rdf:type schema:DefinedTerm
148 Nc21e10f7d60142d18c2ae802b849495d rdf:first sg:person.01173355062.13
149 rdf:rest N1dfc8790a9f840908cb098e1200af5ee
150 Nc3016cdfcdaa49a0858dcbe4dd3c23c1 schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 Nc5644219c0474a30990423fd64754f24 rdf:first sg:person.0772164322.12
153 rdf:rest N30e9bfa9db604853a11edf142a8b4e8b
154 Nd1acb3457cca4cf8954660d2a90c2a7e rdf:first sg:person.0716560561.35
155 rdf:rest rdf:nil
156 Nec52791961f3422db8d84d0426b017e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Retinal Ganglion Cells
158 rdf:type schema:DefinedTerm
159 Nefa0a812cf1a4b4f95617b71fbb0a6c3 schema:name Department of Ophthalmology, Mie University Graduate School, School of Medicine, Mie, Japan
160 rdf:type schema:Organization
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
165 schema:name Ophthalmology and Optometry
166 rdf:type schema:DefinedTerm
167 sg:grant.5859216 http://pending.schema.org/fundedItem sg:pub.10.1007/s10384-015-0400-6
168 rdf:type schema:MonetaryGrant
169 sg:grant.6153804 http://pending.schema.org/fundedItem sg:pub.10.1007/s10384-015-0400-6
170 rdf:type schema:MonetaryGrant
171 sg:journal.1005673 schema:issn 0021-5155
172 1613-2246
173 schema:name Japanese Journal of Ophthalmology
174 rdf:type schema:Periodical
175 sg:person.01116406051.77 schema:affiliation https://www.grid.ac/institutes/grid.410786.c
176 schema:familyName Ishikawa
177 schema:givenName Hitoshi
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116406051.77
179 rdf:type schema:Person
180 sg:person.01173355062.13 schema:affiliation https://www.grid.ac/institutes/grid.410786.c
181 schema:familyName Shimizu
182 schema:givenName Kimiya
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173355062.13
184 rdf:type schema:Person
185 sg:person.013003065207.03 schema:affiliation Nefa0a812cf1a4b4f95617b71fbb0a6c3
186 schema:familyName Kondo
187 schema:givenName Mineo
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013003065207.03
189 rdf:type schema:Person
190 sg:person.0606677062.99 schema:affiliation https://www.grid.ac/institutes/grid.410786.c
191 schema:familyName Asakawa
192 schema:givenName Ken
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606677062.99
194 rdf:type schema:Person
195 sg:person.0617516171.61 schema:affiliation https://www.grid.ac/institutes/grid.410786.c
196 schema:familyName Mashimo
197 schema:givenName Kimiyo
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617516171.61
199 rdf:type schema:Person
200 sg:person.0716560561.35 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
201 schema:familyName Terasaki
202 schema:givenName Hiroko
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716560561.35
204 rdf:type schema:Person
205 sg:person.0772164322.12 schema:affiliation https://www.grid.ac/institutes/grid.410786.c
206 schema:familyName Uga
207 schema:givenName Shigekazu
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772164322.12
209 rdf:type schema:Person
210 sg:pub.10.1007/bf00142525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049085077
211 https://doi.org/10.1007/bf00142525
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/bf00236786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039923802
214 https://doi.org/10.1007/bf00236786
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/bf02157769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048079189
217 https://doi.org/10.1007/bf02157769
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s10384-010-0842-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100932
220 https://doi.org/10.1007/s10384-010-0842-9
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s10384-011-0116-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039132512
223 https://doi.org/10.1007/s10384-011-0116-1
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s10384-012-0147-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008837420
226 https://doi.org/10.1007/s10384-012-0147-2
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s10633-008-9155-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048157101
229 https://doi.org/10.1007/s10633-008-9155-4
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/80639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049247362
232 https://doi.org/10.1038/80639
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/88443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024154404
235 https://doi.org/10.1038/88443
236 rdf:type schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1074692377 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1074775232 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1074860868 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1077172579 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082583480 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082662864 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082821292 schema:CreativeWork
244 https://doi.org/10.1001/archopht.1992.01080230134038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016537440
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/cne.22703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035297158
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0042-6989(85)90056-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032519798
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.ajo.2006.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010206693
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.visres.2013.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002027133
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s0002-9394(14)73708-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013318572
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0140-6736(06)69740-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050875870
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1017/s0952523800006799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017226065
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1073/pnas.072557799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022869578
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1073/pnas.93.24.14176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045812488
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1083/jcb.17.1.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024183842
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1126/science.101.2635.653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062442384
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1126/science.7824934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649828
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1136/bjo.65.1.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022864598
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1152/physrev.1991.71.2.447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078033004
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1167/iovs.07-0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025154074
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1167/iovs.08-2863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008252881
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1167/iovs.09-3458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029767543
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1167/iovs.11-7611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003983215
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1167/iovs.11-9006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030520626
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1167/iovs.11-9067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013552072
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1371/journal.pone.0036135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037238637
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1523/jneurosci.20-02-00600.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074575276
289 rdf:type schema:CreativeWork
290 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
291 schema:name Department of Ophthalmology, Nagoya University Graduate School, School of Medicine, Nagoya, Japan
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.410786.c schema:alternateName Kitasato University
294 schema:name Department of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
295 Department of Orthoptics and Visual Science, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, 252-0373, Sagamihara, Kanagawa, Japan
296 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...