Selective ophthalmic arterial injection of melphalan for intraocular retinoblastoma: a 4-year review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03

AUTHORS

Sherine Jue Ong, An-Ning Chao, Ho-Fai Wong, Kuan-Lyin Liou, Ling-Yuh Kao

ABSTRACT

PURPOSE: To describe tumor response and complications after selective ophthalmic arterial injection (SOAI) of melphalan for treatment of intraocular retinoblastoma. METHODS: A retrospective review of 17 eyes (12 patients) treated with SOAI of melphalan from January 2010 through December 2013 at Chang Gung Memorial Hospital. RESULTS: SOAI was successfully performed in 49 of 54 attempts. Six eyes underwent SOAI as the primary treatment and 11 eyes had previously been treated with other treatment modalities. Subsequent to SOAI, tumor regression was observed in 12 of 17 eyes, and vitreous seeding with complete or partial regression in ten of 15 eyes. Globe salvage was achieved in ten of 17 eyes, with three of four in group B and group C eyes, and seven of 13 in group D and group E eyes. Pancytopenia accompanied by neutropenic fever was observed in one case. Twelve eyes had local side effects, including lid edema (two eyes), third cranial nerve palsy (two eyes), sixth cranial nerve palsy (one eye), chorioretinal atrophy (six eyes), retinal arterial occlusion (three eyes), retinal detachment (one eye), and vitreous hemorrhage (seven eyes). Three cases with high-risk features, according to the histopathologic examination, had metastatic disease, and two of them died. CONCLUSIONS: SOAI of melphalan is an effective treatment for intraocular retinoblastoma, achieving high globe salvage in cases of advanced disease, but can be associated with significant ocular complications. Repetitive SOAI with delayed enucleation could increase the risk of metastasis when used in high-risk cases. Therefore, clinicians should consider the benefits and potential risks and use this new technique with caution. More... »

PAGES

109-117

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y

DOI

http://dx.doi.org/10.1007/s10384-014-0356-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016290384

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25465196


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Alkylating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intra-Arterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melphalan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ophthalmic Artery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Keelung Chang Gung Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.454209.e", 
          "name": [
            "Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ong", 
        "givenName": "Sherine Jue", 
        "id": "sg:person.01053551544.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053551544.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chao", 
        "givenName": "An-Ning", 
        "id": "sg:person.011145525612.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011145525612.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "Ho-Fai", 
        "id": "sg:person.0740610414.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740610414.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liou", 
        "givenName": "Kuan-Lyin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kao", 
        "givenName": "Ling-Yuh", 
        "id": "sg:person.01263120741.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263120741.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/bjo.2009.177444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001506250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2010.296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003258595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2011.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003467483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2011.304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003778010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-004-0392-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004047769", 
          "https://doi.org/10.1007/s10147-004-0392-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s12665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004730721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s12665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004730721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.2008.150292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004899235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2011.08.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005040615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2011.150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008816641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2011.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011224891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-003-0366-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012707891", 
          "https://doi.org/10.1007/s10147-003-0366-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.120.12.1653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013458808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.77.9.544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013567850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0b013e3283524130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013886312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0b013e3283524130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013886312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0b013e3283524130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013886312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2009.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017704571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9394(02)01348-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018893240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1442-9071.2010.02297.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023375657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1442-9071.2010.02297.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023375657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2011.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026250548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/eye.2009.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028585419", 
          "https://doi.org/10.1038/eye.2009.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/eye.2009.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028585419", 
          "https://doi.org/10.1038/eye.2009.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2011.361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030439008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940201)73:3<692::aid-cncr2820730331>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032085572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.126.6.862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033011350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.2009.174268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038324451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2011.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039152788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2009.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040577034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/iae.0b013e318203c101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043838600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/iae.0b013e318203c101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043838600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2007.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044581528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjophthalmol-2011-300498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047156927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s43398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049748773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s43398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049748773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s24318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051739522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s24318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051739522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0b013e328338676a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051992787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0b013e328338676a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051992787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0b013e328338676a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051992787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-3768.2011.02296.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052652334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2011.1.jns10466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071076173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2011.1.jns10466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071076173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2011.1.jns10466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071076173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1043/1543-2165-133.8.1203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077940528"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-03", 
    "datePublishedReg": "2015-03-01", 
    "description": "PURPOSE: To describe tumor response and complications after selective ophthalmic arterial injection (SOAI) of melphalan for treatment of intraocular retinoblastoma.\nMETHODS: A retrospective review of 17 eyes (12 patients) treated with SOAI of melphalan from January 2010 through December 2013 at Chang Gung Memorial Hospital.\nRESULTS: SOAI was successfully performed in 49 of 54 attempts. Six eyes underwent SOAI as the primary treatment and 11 eyes had previously been treated with other treatment modalities. Subsequent to SOAI, tumor regression was observed in 12 of 17 eyes, and vitreous seeding with complete or partial regression in ten of 15 eyes. Globe salvage was achieved in ten of 17 eyes, with three of four in group B and group C eyes, and seven of 13 in group D and group E eyes. Pancytopenia accompanied by neutropenic fever was observed in one case. Twelve eyes had local side effects, including lid edema (two eyes), third cranial nerve palsy (two eyes), sixth cranial nerve palsy (one eye), chorioretinal atrophy (six eyes), retinal arterial occlusion (three eyes), retinal detachment (one eye), and vitreous hemorrhage (seven eyes). Three cases with high-risk features, according to the histopathologic examination, had metastatic disease, and two of them died.\nCONCLUSIONS: SOAI of melphalan is an effective treatment for intraocular retinoblastoma, achieving high globe salvage in cases of advanced disease, but can be associated with significant ocular complications. Repetitive SOAI with delayed enucleation could increase the risk of metastasis when used in high-risk cases. Therefore, clinicians should consider the benefits and potential risks and use this new technique with caution.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10384-014-0356-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1005673", 
        "issn": [
          "0021-5155", 
          "1613-2246"
        ], 
        "name": "Japanese Journal of Ophthalmology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "59"
      }
    ], 
    "name": "Selective ophthalmic arterial injection of melphalan for intraocular retinoblastoma: a 4-year review", 
    "pagination": "109-117", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4d9ec1d7b33af64a20022fb21025de09801db468d3cbdd0ecd614beef15bf756"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25465196"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0044652"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10384-014-0356-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016290384"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10384-014-0356-y", 
      "https://app.dimensions.ai/details/publication/pub.1016290384"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000487.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10384-014-0356-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      76 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10384-014-0356-y schema:about N24729cbc3b8642e2a86809e31ae42127
2 N3614c46ce1804f88b0b569e72682f6f9
3 N4a0c2c67aed24e64adb288792a6ab981
4 N5d919954e1aa4242b2a395696681e64f
5 N5d9e180a133b40a19d173fe493db7912
6 N71bc0481f70f4888ba05955751142073
7 N77fdd375501a456ba04f3aca01a3790b
8 N8753cf98327b4422be2997d4dc64c1de
9 N89c0344dcb704df89f2130b2f1db9920
10 N8dcc6dc12f21400cbe0dc8e57c8e7e12
11 Nb097f4b4e0d04e1dbebd2429b6ec440b
12 Nba66ea7debc243d1af2210e5fbf79187
13 Nef0eea928ebc46b3954a904cbac895e1
14 anzsrc-for:11
15 anzsrc-for:1113
16 schema:author N94d96abd163b4aff91bc25a66d8f681f
17 schema:citation sg:pub.10.1007/s10147-003-0366-0
18 sg:pub.10.1007/s10147-004-0392-6
19 sg:pub.10.1038/eye.2009.80
20 https://doi.org/10.1001/archopht.120.12.1653
21 https://doi.org/10.1001/archopht.126.6.862
22 https://doi.org/10.1001/archophthalmol.2010.296
23 https://doi.org/10.1001/archophthalmol.2011.150
24 https://doi.org/10.1001/archophthalmol.2011.151
25 https://doi.org/10.1001/archophthalmol.2011.223
26 https://doi.org/10.1001/archophthalmol.2011.304
27 https://doi.org/10.1001/archophthalmol.2011.361
28 https://doi.org/10.1001/archophthalmol.2011.5
29 https://doi.org/10.1002/1097-0142(19940201)73:3<692::aid-cncr2820730331>3.0.co;2-8
30 https://doi.org/10.1016/j.ophtha.2007.12.014
31 https://doi.org/10.1016/j.ophtha.2009.02.018
32 https://doi.org/10.1016/j.ophtha.2009.12.030
33 https://doi.org/10.1016/j.ophtha.2011.03.013
34 https://doi.org/10.1016/j.ophtha.2011.08.045
35 https://doi.org/10.1016/s0002-9394(02)01348-x
36 https://doi.org/10.1043/1543-2165-133.8.1203
37 https://doi.org/10.1097/iae.0b013e318203c101
38 https://doi.org/10.1097/icu.0b013e328338676a
39 https://doi.org/10.1097/icu.0b013e3283524130
40 https://doi.org/10.1111/j.1442-9071.2010.02297.x
41 https://doi.org/10.1111/j.1755-3768.2011.02296.x
42 https://doi.org/10.1136/bjo.2008.150292
43 https://doi.org/10.1136/bjo.2009.174268
44 https://doi.org/10.1136/bjo.2009.177444
45 https://doi.org/10.1136/bjo.77.9.544
46 https://doi.org/10.1136/bjophthalmol-2011-300498
47 https://doi.org/10.2147/opth.s12665
48 https://doi.org/10.2147/opth.s24318
49 https://doi.org/10.2147/opth.s43398
50 https://doi.org/10.3171/2011.1.jns10466
51 schema:datePublished 2015-03
52 schema:datePublishedReg 2015-03-01
53 schema:description PURPOSE: To describe tumor response and complications after selective ophthalmic arterial injection (SOAI) of melphalan for treatment of intraocular retinoblastoma. METHODS: A retrospective review of 17 eyes (12 patients) treated with SOAI of melphalan from January 2010 through December 2013 at Chang Gung Memorial Hospital. RESULTS: SOAI was successfully performed in 49 of 54 attempts. Six eyes underwent SOAI as the primary treatment and 11 eyes had previously been treated with other treatment modalities. Subsequent to SOAI, tumor regression was observed in 12 of 17 eyes, and vitreous seeding with complete or partial regression in ten of 15 eyes. Globe salvage was achieved in ten of 17 eyes, with three of four in group B and group C eyes, and seven of 13 in group D and group E eyes. Pancytopenia accompanied by neutropenic fever was observed in one case. Twelve eyes had local side effects, including lid edema (two eyes), third cranial nerve palsy (two eyes), sixth cranial nerve palsy (one eye), chorioretinal atrophy (six eyes), retinal arterial occlusion (three eyes), retinal detachment (one eye), and vitreous hemorrhage (seven eyes). Three cases with high-risk features, according to the histopathologic examination, had metastatic disease, and two of them died. CONCLUSIONS: SOAI of melphalan is an effective treatment for intraocular retinoblastoma, achieving high globe salvage in cases of advanced disease, but can be associated with significant ocular complications. Repetitive SOAI with delayed enucleation could increase the risk of metastasis when used in high-risk cases. Therefore, clinicians should consider the benefits and potential risks and use this new technique with caution.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N350cf2c7b3654083bf4f3ffdd5a4a7a6
58 N69e85b27bf2c451fb0a7e0aa0d66b43e
59 sg:journal.1005673
60 schema:name Selective ophthalmic arterial injection of melphalan for intraocular retinoblastoma: a 4-year review
61 schema:pagination 109-117
62 schema:productId N8a54e8d602804ca6941589408a978cb0
63 Ndb15cef7f89349b78bea4e8d5d5a83af
64 Ne74eb60d06924adea8f65ce8e0919901
65 Neb1799f3c85c4f23a01075c177834684
66 Nf6b92364a3a743268706f608e570fb73
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016290384
68 https://doi.org/10.1007/s10384-014-0356-y
69 schema:sdDatePublished 2019-04-10T19:03
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher Nf2fbdfe079d846d69e621715ba3a88d9
72 schema:url http://link.springer.com/10.1007/s10384-014-0356-y
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N24729cbc3b8642e2a86809e31ae42127 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Infant
78 rdf:type schema:DefinedTerm
79 N350cf2c7b3654083bf4f3ffdd5a4a7a6 schema:issueNumber 2
80 rdf:type schema:PublicationIssue
81 N3614c46ce1804f88b0b569e72682f6f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Male
83 rdf:type schema:DefinedTerm
84 N4a0c2c67aed24e64adb288792a6ab981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Melphalan
86 rdf:type schema:DefinedTerm
87 N5d919954e1aa4242b2a395696681e64f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Humans
89 rdf:type schema:DefinedTerm
90 N5d9e180a133b40a19d173fe493db7912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Retrospective Studies
92 rdf:type schema:DefinedTerm
93 N65aac8e9840c40e88f91c555a673a928 schema:affiliation Na6f93a18d14f40139302b7be8cc1af1e
94 schema:familyName Liou
95 schema:givenName Kuan-Lyin
96 rdf:type schema:Person
97 N69e85b27bf2c451fb0a7e0aa0d66b43e schema:volumeNumber 59
98 rdf:type schema:PublicationVolume
99 N71bc0481f70f4888ba05955751142073 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Ophthalmic Artery
101 rdf:type schema:DefinedTerm
102 N77fdd375501a456ba04f3aca01a3790b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Child, Preschool
104 rdf:type schema:DefinedTerm
105 N7fc37a3b1d8843d194ce45a0fa7cf29f schema:name Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan
106 rdf:type schema:Organization
107 N8753cf98327b4422be2997d4dc64c1de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N89c0344dcb704df89f2130b2f1db9920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Antineoplastic Agents, Alkylating
112 rdf:type schema:DefinedTerm
113 N8a54e8d602804ca6941589408a978cb0 schema:name nlm_unique_id
114 schema:value 0044652
115 rdf:type schema:PropertyValue
116 N8dcc6dc12f21400cbe0dc8e57c8e7e12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Follow-Up Studies
118 rdf:type schema:DefinedTerm
119 N94d96abd163b4aff91bc25a66d8f681f rdf:first sg:person.01053551544.17
120 rdf:rest Nfe2ea6c2a96f453a95c22dc8e8aa313d
121 N952e75d64b6a41f89fd75406fcfb59da schema:name Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan
122 rdf:type schema:Organization
123 Na6f93a18d14f40139302b7be8cc1af1e schema:name Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan
124 rdf:type schema:Organization
125 Nb097f4b4e0d04e1dbebd2429b6ec440b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Injections, Intra-Arterial
127 rdf:type schema:DefinedTerm
128 Nba66ea7debc243d1af2210e5fbf79187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Retinal Neoplasms
130 rdf:type schema:DefinedTerm
131 Nc15e46af39e64ffe9d1f74d5deb9b410 schema:name Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan
132 rdf:type schema:Organization
133 Ndb15cef7f89349b78bea4e8d5d5a83af schema:name dimensions_id
134 schema:value pub.1016290384
135 rdf:type schema:PropertyValue
136 Ne563a17dd29c47c7a87e849567ae1e14 rdf:first sg:person.01263120741.48
137 rdf:rest rdf:nil
138 Ne628208b069f4f12b394ea8557960381 rdf:first sg:person.0740610414.52
139 rdf:rest Nf00aec2d4d6c497d8ac092ce125e2bab
140 Ne74eb60d06924adea8f65ce8e0919901 schema:name readcube_id
141 schema:value 4d9ec1d7b33af64a20022fb21025de09801db468d3cbdd0ecd614beef15bf756
142 rdf:type schema:PropertyValue
143 Neb1799f3c85c4f23a01075c177834684 schema:name pubmed_id
144 schema:value 25465196
145 rdf:type schema:PropertyValue
146 Nef0eea928ebc46b3954a904cbac895e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Retinoblastoma
148 rdf:type schema:DefinedTerm
149 Nf00aec2d4d6c497d8ac092ce125e2bab rdf:first N65aac8e9840c40e88f91c555a673a928
150 rdf:rest Ne563a17dd29c47c7a87e849567ae1e14
151 Nf2fbdfe079d846d69e621715ba3a88d9 schema:name Springer Nature - SN SciGraph project
152 rdf:type schema:Organization
153 Nf6b92364a3a743268706f608e570fb73 schema:name doi
154 schema:value 10.1007/s10384-014-0356-y
155 rdf:type schema:PropertyValue
156 Nfe2ea6c2a96f453a95c22dc8e8aa313d rdf:first sg:person.011145525612.14
157 rdf:rest Ne628208b069f4f12b394ea8557960381
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
162 schema:name Ophthalmology and Optometry
163 rdf:type schema:DefinedTerm
164 sg:journal.1005673 schema:issn 0021-5155
165 1613-2246
166 schema:name Japanese Journal of Ophthalmology
167 rdf:type schema:Periodical
168 sg:person.01053551544.17 schema:affiliation https://www.grid.ac/institutes/grid.454209.e
169 schema:familyName Ong
170 schema:givenName Sherine Jue
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053551544.17
172 rdf:type schema:Person
173 sg:person.011145525612.14 schema:affiliation N952e75d64b6a41f89fd75406fcfb59da
174 schema:familyName Chao
175 schema:givenName An-Ning
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011145525612.14
177 rdf:type schema:Person
178 sg:person.01263120741.48 schema:affiliation Nc15e46af39e64ffe9d1f74d5deb9b410
179 schema:familyName Kao
180 schema:givenName Ling-Yuh
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263120741.48
182 rdf:type schema:Person
183 sg:person.0740610414.52 schema:affiliation N7fc37a3b1d8843d194ce45a0fa7cf29f
184 schema:familyName Wong
185 schema:givenName Ho-Fai
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740610414.52
187 rdf:type schema:Person
188 sg:pub.10.1007/s10147-003-0366-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012707891
189 https://doi.org/10.1007/s10147-003-0366-0
190 rdf:type schema:CreativeWork
191 sg:pub.10.1007/s10147-004-0392-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004047769
192 https://doi.org/10.1007/s10147-004-0392-6
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/eye.2009.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028585419
195 https://doi.org/10.1038/eye.2009.80
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1001/archopht.120.12.1653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013458808
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1001/archopht.126.6.862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033011350
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1001/archophthalmol.2010.296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003258595
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1001/archophthalmol.2011.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008816641
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1001/archophthalmol.2011.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026250548
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1001/archophthalmol.2011.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011224891
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1001/archophthalmol.2011.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003778010
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1001/archophthalmol.2011.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030439008
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1001/archophthalmol.2011.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039152788
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/1097-0142(19940201)73:3<692::aid-cncr2820730331>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032085572
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.ophtha.2007.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044581528
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ophtha.2009.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017704571
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ophtha.2009.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040577034
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.ophtha.2011.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003467483
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.ophtha.2011.08.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005040615
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0002-9394(02)01348-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018893240
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1043/1543-2165-133.8.1203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077940528
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1097/iae.0b013e318203c101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043838600
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/icu.0b013e328338676a schema:sameAs https://app.dimensions.ai/details/publication/pub.1051992787
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1097/icu.0b013e3283524130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013886312
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1111/j.1442-9071.2010.02297.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023375657
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/j.1755-3768.2011.02296.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052652334
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1136/bjo.2008.150292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004899235
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1136/bjo.2009.174268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038324451
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1136/bjo.2009.177444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001506250
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1136/bjo.77.9.544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013567850
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1136/bjophthalmol-2011-300498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047156927
250 rdf:type schema:CreativeWork
251 https://doi.org/10.2147/opth.s12665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004730721
252 rdf:type schema:CreativeWork
253 https://doi.org/10.2147/opth.s24318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051739522
254 rdf:type schema:CreativeWork
255 https://doi.org/10.2147/opth.s43398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049748773
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3171/2011.1.jns10466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071076173
258 rdf:type schema:CreativeWork
259 https://www.grid.ac/institutes/grid.454209.e schema:alternateName Keelung Chang Gung Memorial Hospital
260 schema:name Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...