Ontology type: schema:ScholarlyArticle
2015-03
AUTHORSSherine Jue Ong, An-Ning Chao, Ho-Fai Wong, Kuan-Lyin Liou, Ling-Yuh Kao
ABSTRACTPURPOSE: To describe tumor response and complications after selective ophthalmic arterial injection (SOAI) of melphalan for treatment of intraocular retinoblastoma. METHODS: A retrospective review of 17 eyes (12 patients) treated with SOAI of melphalan from January 2010 through December 2013 at Chang Gung Memorial Hospital. RESULTS: SOAI was successfully performed in 49 of 54 attempts. Six eyes underwent SOAI as the primary treatment and 11 eyes had previously been treated with other treatment modalities. Subsequent to SOAI, tumor regression was observed in 12 of 17 eyes, and vitreous seeding with complete or partial regression in ten of 15 eyes. Globe salvage was achieved in ten of 17 eyes, with three of four in group B and group C eyes, and seven of 13 in group D and group E eyes. Pancytopenia accompanied by neutropenic fever was observed in one case. Twelve eyes had local side effects, including lid edema (two eyes), third cranial nerve palsy (two eyes), sixth cranial nerve palsy (one eye), chorioretinal atrophy (six eyes), retinal arterial occlusion (three eyes), retinal detachment (one eye), and vitreous hemorrhage (seven eyes). Three cases with high-risk features, according to the histopathologic examination, had metastatic disease, and two of them died. CONCLUSIONS: SOAI of melphalan is an effective treatment for intraocular retinoblastoma, achieving high globe salvage in cases of advanced disease, but can be associated with significant ocular complications. Repetitive SOAI with delayed enucleation could increase the risk of metastasis when used in high-risk cases. Therefore, clinicians should consider the benefits and potential risks and use this new technique with caution. More... »
PAGES109-117
http://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y
DOIhttp://dx.doi.org/10.1007/s10384-014-0356-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1016290384
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25465196
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Ophthalmology and Optometry",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents, Alkylating",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child, Preschool",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Injections, Intra-Arterial",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Melphalan",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ophthalmic Artery",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retinal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retinoblastoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Keelung Chang Gung Memorial Hospital",
"id": "https://www.grid.ac/institutes/grid.454209.e",
"name": [
"Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan"
],
"type": "Organization"
},
"familyName": "Ong",
"givenName": "Sherine Jue",
"id": "sg:person.01053551544.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053551544.17"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Chao",
"givenName": "An-Ning",
"id": "sg:person.011145525612.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011145525612.14"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Wong",
"givenName": "Ho-Fai",
"id": "sg:person.0740610414.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740610414.52"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Liou",
"givenName": "Kuan-Lyin",
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Kao",
"givenName": "Ling-Yuh",
"id": "sg:person.01263120741.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263120741.48"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1136/bjo.2009.177444",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001506250"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archophthalmol.2010.296",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003258595"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ophtha.2011.03.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003467483"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archophthalmol.2011.304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003778010"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-004-0392-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004047769",
"https://doi.org/10.1007/s10147-004-0392-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/opth.s12665",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004730721"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/opth.s12665",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004730721"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bjo.2008.150292",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004899235"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ophtha.2011.08.045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005040615"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archophthalmol.2011.150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008816641"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archophthalmol.2011.223",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011224891"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-003-0366-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012707891",
"https://doi.org/10.1007/s10147-003-0366-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archopht.120.12.1653",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013458808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bjo.77.9.544",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013567850"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/icu.0b013e3283524130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013886312"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/icu.0b013e3283524130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013886312"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/icu.0b013e3283524130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013886312"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ophtha.2009.02.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017704571"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9394(02)01348-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018893240"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1442-9071.2010.02297.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023375657"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1442-9071.2010.02297.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023375657"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archophthalmol.2011.151",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026250548"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/eye.2009.80",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028585419",
"https://doi.org/10.1038/eye.2009.80"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/eye.2009.80",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028585419",
"https://doi.org/10.1038/eye.2009.80"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archophthalmol.2011.361",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030439008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19940201)73:3<692::aid-cncr2820730331>3.0.co;2-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032085572"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archopht.126.6.862",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033011350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bjo.2009.174268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038324451"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archophthalmol.2011.5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039152788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ophtha.2009.12.030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040577034"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/iae.0b013e318203c101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043838600"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/iae.0b013e318203c101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043838600"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ophtha.2007.12.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044581528"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bjophthalmol-2011-300498",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047156927"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/opth.s43398",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049748773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/opth.s43398",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049748773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/opth.s24318",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051739522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/opth.s24318",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051739522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/icu.0b013e328338676a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051992787"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/icu.0b013e328338676a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051992787"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/icu.0b013e328338676a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051992787"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1755-3768.2011.02296.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052652334"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2011.1.jns10466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071076173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2011.1.jns10466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071076173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2011.1.jns10466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071076173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1043/1543-2165-133.8.1203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077940528"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-03",
"datePublishedReg": "2015-03-01",
"description": "PURPOSE: To describe tumor response and complications after selective ophthalmic arterial injection (SOAI) of melphalan for treatment of intraocular retinoblastoma.\nMETHODS: A retrospective review of 17 eyes (12 patients) treated with SOAI of melphalan from January 2010 through December 2013 at Chang Gung Memorial Hospital.\nRESULTS: SOAI was successfully performed in 49 of 54 attempts. Six eyes underwent SOAI as the primary treatment and 11 eyes had previously been treated with other treatment modalities. Subsequent to SOAI, tumor regression was observed in 12 of 17 eyes, and vitreous seeding with complete or partial regression in ten of 15 eyes. Globe salvage was achieved in ten of 17 eyes, with three of four in group B and group C eyes, and seven of 13 in group D and group E eyes. Pancytopenia accompanied by neutropenic fever was observed in one case. Twelve eyes had local side effects, including lid edema (two eyes), third cranial nerve palsy (two eyes), sixth cranial nerve palsy (one eye), chorioretinal atrophy (six eyes), retinal arterial occlusion (three eyes), retinal detachment (one eye), and vitreous hemorrhage (seven eyes). Three cases with high-risk features, according to the histopathologic examination, had metastatic disease, and two of them died.\nCONCLUSIONS: SOAI of melphalan is an effective treatment for intraocular retinoblastoma, achieving high globe salvage in cases of advanced disease, but can be associated with significant ocular complications. Repetitive SOAI with delayed enucleation could increase the risk of metastasis when used in high-risk cases. Therefore, clinicians should consider the benefits and potential risks and use this new technique with caution.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10384-014-0356-y",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1005673",
"issn": [
"0021-5155",
"1613-2246"
],
"name": "Japanese Journal of Ophthalmology",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "59"
}
],
"name": "Selective ophthalmic arterial injection of melphalan for intraocular retinoblastoma: a 4-year review",
"pagination": "109-117",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"4d9ec1d7b33af64a20022fb21025de09801db468d3cbdd0ecd614beef15bf756"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25465196"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0044652"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10384-014-0356-y"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1016290384"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10384-014-0356-y",
"https://app.dimensions.ai/details/publication/pub.1016290384"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T19:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000487.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s10384-014-0356-y"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10384-014-0356-y'
This table displays all metadata directly associated to this object as RDF triples.
261 TRIPLES
21 PREDICATES
76 URIs
34 LITERALS
22 BLANK NODES