Effect and Mechanism of Betaxolol and Timolol on Vascular Relaxation in Isolated Rabbit Ciliary Artery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-11

AUTHORS

Yaru Dong, Hitoshi Ishikawa, Yazhen Wu, Kimiya Shimizu, Toshiaki Goseki, Takeshi Yoshitomi

ABSTRACT

PURPOSE: In order to clarify the vasodilatory mechanism of betaxolol and timolol, we studied the effects of these drugs in isolated rabbit ciliary arteries. METHODS: Rabbit ciliary artery specimens were mounted in a double myograph system, and betaxolol, timolol, or another agent was introduced into the organ chamber. The mechanical response of the arteries was studied using an isometric tension recording method. The intracellular free calcium concentration [Ca2+]i was also measured using fluorescence photometry. RESULTS: Betaxolol and timolol induced dose-dependent relaxation in the rabbit ciliary arteries precontracted by high-K+ Krebs solution. The minimum concentrations required to cause relaxation were 10 microM of betaxolol, and 30 microM of timolol. At the maximum concentration of 1 mM, betaxolol induced almost complete relaxation of the ciliary arteries, whereas timolol induced approximately 70% relaxation. These actions were not inhibited by pretreatment with 100 microM NG-nitro-l-arginine methylester (L-NAME), a nitric oxide synthase inhibitor, or by denudation of the vascular endothelium. However, 300 microM of betaxolol or timolol decreased the [Ca2+]i of the vascular smooth muscle, an action similar to that of diltiazem, a typical L-type voltage calcium-channel blocker. CONCLUSIONS: Betaxolol, a selective beta1-adrenoceptor antagonist, and timolol, a nonselective beta-adrenoceptor antagonist, both frequently used in the medical management of glaucoma, decrease [Ca2+]i by acting as Ca2+ channel blockers, thus causing relaxation of isolated rabbit ciliary artery. More... »

PAGES

504-508

References to SciGraph publications

  • 1999-07. Effects of β antagonists on mechanical properties in rabbit ciliary artery in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2002-02. Pharmacological effects of latanoprost, prostaglandin E2, and F2α on isolated rabbit ciliary artery in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2001-07. Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10384-006-0377-2

    DOI

    http://dx.doi.org/10.1007/s10384-006-0377-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012170390

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17180523


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