The role for surgeryin high-risk prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

Cécilia Lanchon, Shahrokh F. Shariat, Morgan Rouprêt

ABSTRACT

High-risk prostate cancer (PCa) refers to a very heterogeneous subgroup of disease. Recent series have shown very promising results of radical prostatectomy (RP)-alone or part as a multimodality approach-in patients with high-risk PCa, with satisfactory survival curves even though biochemical recurrence rate was high. Adjuvant treatment (radiotherapy (RT) alone or combined with androgen deprivation) was necessary in 20 to 54 % of patients, notably in cases with positive surgical margins. As for functional outcomes, urinary continence was preserved in about 92 % of cases and overall potency in 60 %. When comparing RP versus RT as primary treatment for high-risk PCa, a recent meta-analysis found surgery to be associated with an improved cancer-specific mortality compared with RT. In selected high-risk PCa young patients, surgery appears to be a valid option. Patients should however be informed of the possibility of adjuvant treatment, as part of a multimodal approach. More... »

PAGES

395-400

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10354-015-0389-y

DOI

http://dx.doi.org/10.1007/s10354-015-0389-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032651657

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26399721


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