Fibroblast growth factor 8 overexpression is predictive of poor prognosis in pancreatic ductal adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-08

AUTHORS

Gerd Jomrich, Lavinia Wilfing, Sanja Radosavljevic, Ario Parak, Daniel Winkler, Gerald Timelthaler, Martin Schindl, Sebastian F. Schoppmann, Bernhard Klösch

ABSTRACT

BackgroundDespite distinctive advances in the field of pancreatic cancer therapy over the past few years, patient survival remains poor. Fibroblast growth factors 8 (FGF8) and 18 (FGF18) both play a role in modulating the activity of malignant cells and have been identified as promising biomarkers in a number of cancers. However, no data exist on the expression of FGF8 and FGF18 in pancreatic ductal adenocarcinoma (PDAC).MethodsProtein expression levels of FGF8 and FGF18 in postoperative specimens of neoadjuvantly treated and primarily resected patients were investigated using immunohistochemistry. Immunostaining scores were calculated as the products of the staining intensity and the staining rate. Scores exceeding the median score were considered as high expression.ResultsSpecimens from 78 patients with PDAC were available and met the eligibility criteria for analysis of protein expression using immunohistochemistry. 15 (19.2%) patients had received neoadjuvant chemotherapy. High protein levels of FGF8 and FGF18 were detected in 40 (51.8%) and 33 (42.3%) patients, respectively. Kaplan–Meier analysis demonstrated significantly shorter overall survival in patients with high expression of FGF8 (p = 0.04). Multivariable Cox proportional hazard regression models revealed that high expression of FGF8 (Hazard ratio [HR] 0.53, 95% Confidence interval [CI] 0.32–0.89, p = 0.016) was an independent prognostic factor for diminished overall survival in patients with PDAC. By contrast, no statistical significance was found for FGF18 overexpression. In addition, the FGF8 protein level correlated with the factor resection margin (p = 0.042).ConclusionFGF8 is a promising target for new anticancer therapies using FGF inhibitors in pancreatic ductal adenocarcinomas. More... »

PAGES

282-289

References to SciGraph publications

  • 2019-03-13. Minimally invasive pancreatic surgery—where are we going? in EUROPEAN SURGERY
  • 2017-08-01. Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2019-04-10. Evolution of oncosurgical management of pancreatic cancer in EUROPEAN SURGERY
  • 2018-10-01. FGF8 induces therapy resistance in neoadjuvantly radiated rectal cancer in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2019-03-28. Systemic Immune-Inflammation Index (SII) Predicts Poor Survival in Pancreatic Cancer Patients Undergoing Resection in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2018-08-06. FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p in ONCOGENE
  • 2020-01-03. The Prognostic Index Independently Predicts Survival in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Resection in ANNALS OF SURGICAL ONCOLOGY
  • 2019-03-05. Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy in EUROPEAN SURGERY
  • 2010-02-01. Fibroblast growth factor signalling: from development to cancer in NATURE REVIEWS CANCER
  • 2019-05-17. Imaging response evaluation after novel neoadjuvant treatments of pancreatic cancer in EUROPEAN SURGERY
  • 2002-08-15. Fibroblast growth factor 8 expression in breast carcinoma: associations with androgen receptor and prostate-specific antigen expressions in VIRCHOWS ARCHIV
  • 2019-05-15. Management of ductal pancreatic cancer in EUROPEAN SURGERY
  • 1999-04-28. FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10353-020-00669-6

    DOI

    http://dx.doi.org/10.1007/s10353-020-00669-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131537430


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.512189.6", 
              "name": [
                "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria", 
                "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jomrich", 
            "givenName": "Gerd", 
            "id": "sg:person.01133240777.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133240777.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilfing", 
            "givenName": "Lavinia", 
            "id": "sg:person.010324377405.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010324377405.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Radosavljevic", 
            "givenName": "Sanja", 
            "id": "sg:person.011717340405.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011717340405.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parak", 
            "givenName": "Ario", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vienna University of Economics and Business, Welthandelsplatz\u00a01, 1020, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.15788.33", 
              "name": [
                "Vienna University of Economics and Business, Welthandelsplatz\u00a01, 1020, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winkler", 
            "givenName": "Daniel", 
            "id": "sg:person.012776107454.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012776107454.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria", 
                "Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Timelthaler", 
            "givenName": "Gerald", 
            "id": "sg:person.0674116056.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674116056.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.512189.6", 
              "name": [
                "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria", 
                "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schindl", 
            "givenName": "Martin", 
            "id": "sg:person.0603017413.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603017413.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.512189.6", 
              "name": [
                "Department of Surgery, Medical University of Vienna, Spitalgasse\u00a023, 1090, Vienna, Austria", 
                "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schoppmann", 
            "givenName": "Sebastian F.", 
            "id": "sg:person.0660570115.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660570115.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Comprehensive Cancer Center (CCC), Spitalgasse\u00a023, 1090, Vienna, Austria", 
                "Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kl\u00f6sch", 
            "givenName": "Bernhard", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41388-018-0430-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106019061", 
              "https://doi.org/10.1038/s41388-018-0430-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2017.218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090933253", 
              "https://doi.org/10.1038/ajg.2017.218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-018-2757-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107345277", 
              "https://doi.org/10.1007/s00432-018-2757-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10353-019-0583-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1114349026", 
              "https://doi.org/10.1007/s10353-019-0583-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-019-08161-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123813588", 
              "https://doi.org/10.1245/s10434-019-08161-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-019-04187-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113059570", 
              "https://doi.org/10.1007/s11605-019-04187-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10353-019-0576-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112731686", 
              "https://doi.org/10.1007/s10353-019-0576-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10353-019-0575-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112540711", 
              "https://doi.org/10.1007/s10353-019-0575-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025760788", 
              "https://doi.org/10.1038/nrc2780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10353-019-0598-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1114523611", 
              "https://doi.org/10.1007/s10353-019-0598-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-002-0687-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048525089", 
              "https://doi.org/10.1007/s00428-002-0687-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10353-019-0587-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113358534", 
              "https://doi.org/10.1007/s10353-019-0587-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027431068", 
              "https://doi.org/10.1038/sj.onc.1202624"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-10-08", 
        "datePublishedReg": "2020-10-08", 
        "description": "BackgroundDespite distinctive advances in the field of pancreatic cancer therapy over the past few years, patient survival remains poor. Fibroblast growth factors\u00a08 (FGF8) and 18 (FGF18) both play a\u00a0role in modulating the activity of malignant cells and have been identified as promising biomarkers in a\u00a0number of cancers. However, no data exist on the expression of FGF8 and FGF18 in pancreatic ductal adenocarcinoma (PDAC).MethodsProtein expression levels of FGF8 and FGF18 in postoperative specimens of neoadjuvantly treated and primarily resected patients were investigated using immunohistochemistry. Immunostaining scores were calculated as the products of the staining intensity and the staining rate. Scores exceeding the median score were considered as high expression.ResultsSpecimens from 78\u00a0patients with PDAC were available and met the eligibility criteria for analysis of protein expression using immunohistochemistry. 15 (19.2%) patients had received neoadjuvant chemotherapy. High protein levels of FGF8 and FGF18 were detected in 40 (51.8%) and 33 (42.3%) patients, respectively. Kaplan\u2013Meier analysis demonstrated significantly shorter overall survival in patients with high expression of FGF8 (p\u202f=\u20090.04). Multivariable Cox proportional hazard regression models revealed that high expression of FGF8 (Hazard ratio [HR] 0.53, 95% Confidence interval [CI] 0.32\u20130.89, p\u202f=\u20090.016) was an independent prognostic factor for diminished overall survival in patients with PDAC. By contrast, no statistical significance was found for FGF18 overexpression. In addition, the FGF8 protein level correlated with the factor resection margin (p\u202f=\u20090.042).ConclusionFGF8 is a\u00a0promising target for new anticancer therapies using FGF inhibitors in pancreatic ductal adenocarcinomas.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10353-020-00669-6", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1371289", 
            "issn": [
              "1682-8631", 
              "1682-4016"
            ], 
            "name": "European Surgery", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "52"
          }
        ], 
        "keywords": [
          "pancreatic ductal adenocarcinoma", 
          "ductal adenocarcinoma", 
          "overall survival", 
          "high expression", 
          "multivariable Cox proportional hazards regression models", 
          "Cox proportional hazards regression model", 
          "proportional hazards regression models", 
          "diminished overall survival", 
          "independent prognostic factor", 
          "Kaplan-Meier analysis", 
          "shorter overall survival", 
          "protein levels", 
          "hazards regression models", 
          "pancreatic cancer therapy", 
          "number of cancers", 
          "neoadjuvant chemotherapy", 
          "prognostic factors", 
          "resection margins", 
          "patient survival", 
          "poor prognosis", 
          "postoperative specimens", 
          "new anticancer therapies", 
          "immunostaining scores", 
          "staining rate", 
          "eligibility criteria", 
          "patients", 
          "promising biomarker", 
          "malignant cells", 
          "median score", 
          "adenocarcinoma", 
          "protein expression", 
          "anticancer therapy", 
          "promising target", 
          "statistical significance", 
          "higher protein levels", 
          "cancer therapy", 
          "fibroblast growth", 
          "expression levels", 
          "survival", 
          "therapy", 
          "immunohistochemistry", 
          "expression of Fgf8", 
          "FGF inhibitors", 
          "FGF18", 
          "scores", 
          "regression models", 
          "expression", 
          "overexpression", 
          "chemotherapy", 
          "prognosis", 
          "cancer", 
          "levels", 
          "Fgf8", 
          "biomarkers", 
          "inhibitors", 
          "cells", 
          "years", 
          "target", 
          "factors", 
          "criteria", 
          "activity", 
          "ResultsSpecimens", 
          "significance", 
          "role", 
          "specimens", 
          "rate", 
          "contrast", 
          "analysis", 
          "advances", 
          "data", 
          "addition", 
          "margin", 
          "number", 
          "distinctive advances", 
          "growth", 
          "intensity", 
          "model", 
          "products", 
          "field"
        ], 
        "name": "Fibroblast growth factor 8 overexpression is predictive of poor prognosis in pancreatic ductal adenocarcinoma", 
        "pagination": "282-289", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1131537430"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10353-020-00669-6"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10353-020-00669-6", 
          "https://app.dimensions.ai/details/publication/pub.1131537430"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_851.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10353-020-00669-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10353-020-00669-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10353-020-00669-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10353-020-00669-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10353-020-00669-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    253 TRIPLES      22 PREDICATES      117 URIs      96 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10353-020-00669-6 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N8c6a1839bcb74db880727d9f77deea06
    4 schema:citation sg:pub.10.1007/s00428-002-0687-9
    5 sg:pub.10.1007/s00432-018-2757-7
    6 sg:pub.10.1007/s10353-019-0575-z
    7 sg:pub.10.1007/s10353-019-0576-y
    8 sg:pub.10.1007/s10353-019-0583-z
    9 sg:pub.10.1007/s10353-019-0587-8
    10 sg:pub.10.1007/s10353-019-0598-5
    11 sg:pub.10.1007/s11605-019-04187-z
    12 sg:pub.10.1038/ajg.2017.218
    13 sg:pub.10.1038/nrc2780
    14 sg:pub.10.1038/s41388-018-0430-x
    15 sg:pub.10.1038/sj.onc.1202624
    16 sg:pub.10.1245/s10434-019-08161-6
    17 schema:datePublished 2020-10-08
    18 schema:datePublishedReg 2020-10-08
    19 schema:description BackgroundDespite distinctive advances in the field of pancreatic cancer therapy over the past few years, patient survival remains poor. Fibroblast growth factors 8 (FGF8) and 18 (FGF18) both play a role in modulating the activity of malignant cells and have been identified as promising biomarkers in a number of cancers. However, no data exist on the expression of FGF8 and FGF18 in pancreatic ductal adenocarcinoma (PDAC).MethodsProtein expression levels of FGF8 and FGF18 in postoperative specimens of neoadjuvantly treated and primarily resected patients were investigated using immunohistochemistry. Immunostaining scores were calculated as the products of the staining intensity and the staining rate. Scores exceeding the median score were considered as high expression.ResultsSpecimens from 78 patients with PDAC were available and met the eligibility criteria for analysis of protein expression using immunohistochemistry. 15 (19.2%) patients had received neoadjuvant chemotherapy. High protein levels of FGF8 and FGF18 were detected in 40 (51.8%) and 33 (42.3%) patients, respectively. Kaplan–Meier analysis demonstrated significantly shorter overall survival in patients with high expression of FGF8 (p = 0.04). Multivariable Cox proportional hazard regression models revealed that high expression of FGF8 (Hazard ratio [HR] 0.53, 95% Confidence interval [CI] 0.32–0.89, p = 0.016) was an independent prognostic factor for diminished overall survival in patients with PDAC. By contrast, no statistical significance was found for FGF18 overexpression. In addition, the FGF8 protein level correlated with the factor resection margin (p = 0.042).ConclusionFGF8 is a promising target for new anticancer therapies using FGF inhibitors in pancreatic ductal adenocarcinomas.
    20 schema:genre article
    21 schema:inLanguage en
    22 schema:isAccessibleForFree true
    23 schema:isPartOf N12ff0de3baa449628fdb92baf09d4f6b
    24 Ne2d7aaa65c934f8bb6c11615f4e50fe4
    25 sg:journal.1371289
    26 schema:keywords Cox proportional hazards regression model
    27 FGF inhibitors
    28 FGF18
    29 Fgf8
    30 Kaplan-Meier analysis
    31 ResultsSpecimens
    32 activity
    33 addition
    34 adenocarcinoma
    35 advances
    36 analysis
    37 anticancer therapy
    38 biomarkers
    39 cancer
    40 cancer therapy
    41 cells
    42 chemotherapy
    43 contrast
    44 criteria
    45 data
    46 diminished overall survival
    47 distinctive advances
    48 ductal adenocarcinoma
    49 eligibility criteria
    50 expression
    51 expression levels
    52 expression of Fgf8
    53 factors
    54 fibroblast growth
    55 field
    56 growth
    57 hazards regression models
    58 high expression
    59 higher protein levels
    60 immunohistochemistry
    61 immunostaining scores
    62 independent prognostic factor
    63 inhibitors
    64 intensity
    65 levels
    66 malignant cells
    67 margin
    68 median score
    69 model
    70 multivariable Cox proportional hazards regression models
    71 neoadjuvant chemotherapy
    72 new anticancer therapies
    73 number
    74 number of cancers
    75 overall survival
    76 overexpression
    77 pancreatic cancer therapy
    78 pancreatic ductal adenocarcinoma
    79 patient survival
    80 patients
    81 poor prognosis
    82 postoperative specimens
    83 products
    84 prognosis
    85 prognostic factors
    86 promising biomarker
    87 promising target
    88 proportional hazards regression models
    89 protein expression
    90 protein levels
    91 rate
    92 regression models
    93 resection margins
    94 role
    95 scores
    96 shorter overall survival
    97 significance
    98 specimens
    99 staining rate
    100 statistical significance
    101 survival
    102 target
    103 therapy
    104 years
    105 schema:name Fibroblast growth factor 8 overexpression is predictive of poor prognosis in pancreatic ductal adenocarcinoma
    106 schema:pagination 282-289
    107 schema:productId N4b98029207c9419d87e965a01b1d9c39
    108 N5466f5a7d6434e698ca6bbfd5453f72c
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131537430
    110 https://doi.org/10.1007/s10353-020-00669-6
    111 schema:sdDatePublished 2022-05-20T07:37
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher N0ae48a2f23d246b8942d91988f5db625
    114 schema:url https://doi.org/10.1007/s10353-020-00669-6
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N0ae48a2f23d246b8942d91988f5db625 schema:name Springer Nature - SN SciGraph project
    119 rdf:type schema:Organization
    120 N12ff0de3baa449628fdb92baf09d4f6b schema:volumeNumber 52
    121 rdf:type schema:PublicationVolume
    122 N38d22892a48a4747ac5e91c1a917a518 rdf:first sg:person.012776107454.79
    123 rdf:rest N9da978993c6544ecbc886c623b9e9de9
    124 N41be2f9fe1104b36b72028eaf7f28f50 rdf:first sg:person.0603017413.32
    125 rdf:rest N93022c4365fa44619a72e56d2b00df23
    126 N4b98029207c9419d87e965a01b1d9c39 schema:name dimensions_id
    127 schema:value pub.1131537430
    128 rdf:type schema:PropertyValue
    129 N5466f5a7d6434e698ca6bbfd5453f72c schema:name doi
    130 schema:value 10.1007/s10353-020-00669-6
    131 rdf:type schema:PropertyValue
    132 N683622c2e997415cac54cbee5328a35b schema:affiliation grid-institutes:grid.22937.3d
    133 schema:familyName Klösch
    134 schema:givenName Bernhard
    135 rdf:type schema:Person
    136 N77e9f55651df4650a7baf2a5585a7ce7 schema:affiliation grid-institutes:grid.22937.3d
    137 schema:familyName Parak
    138 schema:givenName Ario
    139 rdf:type schema:Person
    140 N8c6a1839bcb74db880727d9f77deea06 rdf:first sg:person.01133240777.58
    141 rdf:rest N98ed13947ddf484e9d843e751d3de3bf
    142 N93022c4365fa44619a72e56d2b00df23 rdf:first sg:person.0660570115.11
    143 rdf:rest Ne8f2fada18334ffd9703f56d5029f530
    144 N98ed13947ddf484e9d843e751d3de3bf rdf:first sg:person.010324377405.28
    145 rdf:rest Nc6c313de35ff4e1eb042ef393323d80b
    146 N9da978993c6544ecbc886c623b9e9de9 rdf:first sg:person.0674116056.53
    147 rdf:rest N41be2f9fe1104b36b72028eaf7f28f50
    148 Nc23916924c1342c48d420a0daca8927a rdf:first N77e9f55651df4650a7baf2a5585a7ce7
    149 rdf:rest N38d22892a48a4747ac5e91c1a917a518
    150 Nc6c313de35ff4e1eb042ef393323d80b rdf:first sg:person.011717340405.96
    151 rdf:rest Nc23916924c1342c48d420a0daca8927a
    152 Ne2d7aaa65c934f8bb6c11615f4e50fe4 schema:issueNumber 6
    153 rdf:type schema:PublicationIssue
    154 Ne8f2fada18334ffd9703f56d5029f530 rdf:first N683622c2e997415cac54cbee5328a35b
    155 rdf:rest rdf:nil
    156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Medical and Health Sciences
    158 rdf:type schema:DefinedTerm
    159 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Oncology and Carcinogenesis
    161 rdf:type schema:DefinedTerm
    162 sg:journal.1371289 schema:issn 1682-4016
    163 1682-8631
    164 schema:name European Surgery
    165 schema:publisher Springer Nature
    166 rdf:type schema:Periodical
    167 sg:person.010324377405.28 schema:affiliation grid-institutes:grid.22937.3d
    168 schema:familyName Wilfing
    169 schema:givenName Lavinia
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010324377405.28
    171 rdf:type schema:Person
    172 sg:person.01133240777.58 schema:affiliation grid-institutes:grid.512189.6
    173 schema:familyName Jomrich
    174 schema:givenName Gerd
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133240777.58
    176 rdf:type schema:Person
    177 sg:person.011717340405.96 schema:affiliation grid-institutes:grid.22937.3d
    178 schema:familyName Radosavljevic
    179 schema:givenName Sanja
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011717340405.96
    181 rdf:type schema:Person
    182 sg:person.012776107454.79 schema:affiliation grid-institutes:grid.15788.33
    183 schema:familyName Winkler
    184 schema:givenName Daniel
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012776107454.79
    186 rdf:type schema:Person
    187 sg:person.0603017413.32 schema:affiliation grid-institutes:grid.512189.6
    188 schema:familyName Schindl
    189 schema:givenName Martin
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603017413.32
    191 rdf:type schema:Person
    192 sg:person.0660570115.11 schema:affiliation grid-institutes:grid.512189.6
    193 schema:familyName Schoppmann
    194 schema:givenName Sebastian F.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660570115.11
    196 rdf:type schema:Person
    197 sg:person.0674116056.53 schema:affiliation grid-institutes:grid.22937.3d
    198 schema:familyName Timelthaler
    199 schema:givenName Gerald
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674116056.53
    201 rdf:type schema:Person
    202 sg:pub.10.1007/s00428-002-0687-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048525089
    203 https://doi.org/10.1007/s00428-002-0687-9
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1007/s00432-018-2757-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107345277
    206 https://doi.org/10.1007/s00432-018-2757-7
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1007/s10353-019-0575-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1112540711
    209 https://doi.org/10.1007/s10353-019-0575-z
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s10353-019-0576-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1112731686
    212 https://doi.org/10.1007/s10353-019-0576-y
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1007/s10353-019-0583-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1114349026
    215 https://doi.org/10.1007/s10353-019-0583-z
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s10353-019-0587-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113358534
    218 https://doi.org/10.1007/s10353-019-0587-8
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1007/s10353-019-0598-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1114523611
    221 https://doi.org/10.1007/s10353-019-0598-5
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1007/s11605-019-04187-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1113059570
    224 https://doi.org/10.1007/s11605-019-04187-z
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/ajg.2017.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090933253
    227 https://doi.org/10.1038/ajg.2017.218
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nrc2780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025760788
    230 https://doi.org/10.1038/nrc2780
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/s41388-018-0430-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1106019061
    233 https://doi.org/10.1038/s41388-018-0430-x
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/sj.onc.1202624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027431068
    236 https://doi.org/10.1038/sj.onc.1202624
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1245/s10434-019-08161-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123813588
    239 https://doi.org/10.1245/s10434-019-08161-6
    240 rdf:type schema:CreativeWork
    241 grid-institutes:grid.15788.33 schema:alternateName Vienna University of Economics and Business, Welthandelsplatz 1, 1020, Vienna, Austria
    242 schema:name Vienna University of Economics and Business, Welthandelsplatz 1, 1020, Vienna, Austria
    243 rdf:type schema:Organization
    244 grid-institutes:grid.22937.3d schema:alternateName Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria
    245 Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria
    246 schema:name Comprehensive Cancer Center (CCC), Spitalgasse 23, 1090, Vienna, Austria
    247 Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria
    248 Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria
    249 rdf:type schema:Organization
    250 grid-institutes:grid.512189.6 schema:alternateName Comprehensive Cancer Center (CCC), Spitalgasse 23, 1090, Vienna, Austria
    251 schema:name Comprehensive Cancer Center (CCC), Spitalgasse 23, 1090, Vienna, Austria
    252 Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria
    253 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...