Indications for liver surgery in benign tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05-22

AUTHORS

Margot Fodor, Florian Primavesi, Eva Braunwarth, Benno Cardini, Thomas Resch, Reto Bale, Daniel Putzer, Benjamin Henninger, Rupert Oberhuber, Manuel Maglione, Christian Margreiter, Stefan Schneeberger, Dietmar Öfner, Stefan Stättner

ABSTRACT

BackgroundManagement of benign liver tumours (BLT) is still object of discussion. Uncertainty still exists about patient selection, details of management, indications for surgical intervention and potential surgery-related complications. The up-to-date strategies for management of the most common benign solid tumours are recapitulated in this article. In addition, recommendations concerning practical issues are presented.MethodsAvailable data from peer-reviewed publications associated with the major controversies concerning treatment strategies of solid BLT were selected through a PubMed literature search.ResultsNon-randomized controlled trials, retrospective series and case reports dominate the literature. Conservative management in BLT is associated with low overall morbidity and mortality when applied in an appropriate patient population. Surgical intervention is indicated solely in the presence of progressive symptoms and suspicion of a malignant change. Linking abdominal symptoms to BLT should be interpreted with caution. No evidence is recorded for malignant transformation in haemangiomas and focal nodular hyperplasia (FNH), while a subgroup of hepatocellular adenoma (HCA) is associated with malignancy. Follow-up controls of BLT at 3 and 6 months should be sufficient to prove the stability of the lesion and its benign nature, after which no long-term follow-up is required routinely. However, many questions regarding this topic remain without definitive answers in the literature.ConclusionConservative management of solid BLT is a worldwide trend, but the available literature does not provide high-grade evidence for this strategy. Consequently, further prospective investigations on the unclear aspects are required. Hence, this article summarises practical highlights of therapeutic strategies. More... »

PAGES

125-131

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10353-018-0536-y

DOI

http://dx.doi.org/10.1007/s10353-018-0536-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104144601

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29875801


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88 report
89 retrospective series
90 search
91 selection
92 series
93 solid benign liver tumors
94 solid tumors
95 stability
96 strategies
97 subgroups
98 surgery
99 surgery-related complications
100 surgical intervention
101 suspicion
102 symptoms
103 therapeutic strategies
104 topic
105 transformation
106 treatment strategies
107 trends
108 trials
109 tumors
110 uncertainty
111 unclear aspects
112 worldwide trend
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