Cyclooxygenase-2 Expression Correlates With Membrane-Type-1 Matrix Metalloproteinase Expression in Colorectal Cancer Tissue View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-08

AUTHORS

Hongfei Guo, Atsushi Tatsuguchi, Seiichi Shinji, Shunji Fujimori, Shu Tanaka, Katya Gudis, Yuichi Sugisaki, Kiyonori Furukawa, Takashi Tajiri, Yuh Fukuda, Teruyuki Kishida, Choitsu Sakamoto

ABSTRACT

PurposeElevated expression of cyclooxygenase-2 has been found in colorectal cancer. One of the mechanisms through which cyclooxygenase-2 affects tumorigenesis is through its overexpression, which leads to increased invasiveness of cancer cells. A crucial step in this pathway is thought to be the induction of membrane-type-1 matrix metalloproteinase, which activates matrix metalloproteinase-2. However, to date there have been few clinicopathologic studies concerning cyclooxygenase-2-mediated invasiveness in human colorectal cancer tissues.MethodsWe performed immunohistochemical analysis of the respective antigens on colorectal cancer specimens obtained by surgical resections from 96 patients with colorectal cancer.ResultsCyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression was positive exclusively in cancer cells in 88 cases (92 percent) and 23 cases (24 percent), respectively. All 23 cases expressing membrane-type-1 matrix metalloproteinase also expressed cyclooxygenase-2. Matrix metalloproteinase-2 expression was positive in cancer cells in 20 cases (21 percent) and stromal cells in 52 cases (54 percent). Expression of matrix metalloproteinase-2 in cancer cells correlated with lymphatic invasion and local recurrence. Statistically, a significant correlation was found between cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression, and membrane-type-1 matrix metalloproteinase and matrix metalloproteinase-2 expression in cancer cells. There was no association between cyclooxygenase-2 expression and matrix metalloproteinase-2 expression. However, immunostaining of serial sections revealed that in the majority of cases examined, nearly 100 percent of cancer cells expressing matrix metalloproteinase-2 also coexpressed cyclooxygenase-2.ConclusionsThis study indicates strong association between both cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression, and membrane-type-1 matrix metalloproteinase and matrix metalloproteinase-2 in colorectal cancer. These results support our thesis of a direct correlation between cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression—with consequent association between cyclooxygenase-2 and matrix metalloproteinase-2 activation, and tumor invasiveness andrecurrence in certain cases of colorectal cancer. More... »

PAGES

1184-1192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10350-006-0588-0

DOI

http://dx.doi.org/10.1007/s10350-006-0588-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042629155

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16752205


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26 schema:description PurposeElevated expression of cyclooxygenase-2 has been found in colorectal cancer. One of the mechanisms through which cyclooxygenase-2 affects tumorigenesis is through its overexpression, which leads to increased invasiveness of cancer cells. A crucial step in this pathway is thought to be the induction of membrane-type-1 matrix metalloproteinase, which activates matrix metalloproteinase-2. However, to date there have been few clinicopathologic studies concerning cyclooxygenase-2-mediated invasiveness in human colorectal cancer tissues.MethodsWe performed immunohistochemical analysis of the respective antigens on colorectal cancer specimens obtained by surgical resections from 96 patients with colorectal cancer.ResultsCyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression was positive exclusively in cancer cells in 88 cases (92 percent) and 23 cases (24 percent), respectively. All 23 cases expressing membrane-type-1 matrix metalloproteinase also expressed cyclooxygenase-2. Matrix metalloproteinase-2 expression was positive in cancer cells in 20 cases (21 percent) and stromal cells in 52 cases (54 percent). Expression of matrix metalloproteinase-2 in cancer cells correlated with lymphatic invasion and local recurrence. Statistically, a significant correlation was found between cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression, and membrane-type-1 matrix metalloproteinase and matrix metalloproteinase-2 expression in cancer cells. There was no association between cyclooxygenase-2 expression and matrix metalloproteinase-2 expression. However, immunostaining of serial sections revealed that in the majority of cases examined, nearly 100 percent of cancer cells expressing matrix metalloproteinase-2 also coexpressed cyclooxygenase-2.ConclusionsThis study indicates strong association between both cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression, and membrane-type-1 matrix metalloproteinase and matrix metalloproteinase-2 in colorectal cancer. These results support our thesis of a direct correlation between cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression—with consequent association between cyclooxygenase-2 and matrix metalloproteinase-2 activation, and tumor invasiveness andrecurrence in certain cases of colorectal cancer.
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32 schema:keywords Cyclooxygenase-2 expression correlates
33 MethodsWe
34 activation
35 analysis
36 antigen
37 association
38 cancer
39 cancer cells
40 cancer specimens
41 cancer tissues
42 cases
43 cells
44 certain cases
45 clinicopathologic study
46 colorectal cancer
47 colorectal cancer specimens
48 colorectal cancer tissues
49 consequent association
50 correlates
51 correlation
52 crucial step
53 cyclooxygenase-2
54 cyclooxygenase-2 expression
55 date
56 direct correlation
57 expression
58 expression correlates
59 human colorectal cancer tissues
60 immunohistochemical analysis
61 induction
62 invasion
63 invasiveness
64 local recurrence
65 lymphatic invasion
66 majority
67 majority of cases
68 matrix metalloproteinase
69 matrix metalloproteinase expression
70 matrix metalloproteinase-2
71 matrix metalloproteinase-2 activation
72 matrix metalloproteinase-2 expression
73 mechanism
74 membrane type 1 matrix metalloproteinase
75 membrane type 1 matrix metalloproteinase (MT1-MMP) expression
76 metalloproteinase
77 metalloproteinase expression
78 metalloproteinase-2
79 metalloproteinase-2 activation
80 metalloproteinase-2 expression
81 overexpression
82 pathway
83 patients
84 percent
85 recurrence
86 resection
87 respective antigens
88 results
89 sections
90 serial sections
91 significant correlation
92 specimens
93 step
94 stromal cells
95 strong association
96 study
97 surgical resection
98 thesis
99 tissue
100 tumorigenesis
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