Enantiomeric Separation of (R,S)-Aclidinium Bromide with Negatively Charged Gamma-Cyclodextrin by CE View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04

AUTHORS

Hana Adamusová, Naděžda Novotná, Zuzana Bosáková, Michal Douša

ABSTRACT

A new CE method for separation of (R,S)-aclidinium bromide enantiomers has been developed and validated. In this method, sulphated γ-CD 4.8% (w/v) in acidic background electrolyte based on potassium dihydrogen phosphate (100 mM, pH = 3.0) buffer was used for the determination in an uncoated fused silica capillary with extended capillary light path. The effect on the resolution of the chiral selector concentration, of the pH of the background electrolyte and also of other parameters was studied. (R)-Aclidinium bromide has therapeutic properties and, thus, a screening method is required for determination of low concentrations of (S)-aclidinium bromide as an optical impurity. The proposed method enables determination of 0.4% (S)-aclidinium bromide as an optical impurity in a synthetic laboratory sample. More... »

PAGES

559-563

References to SciGraph publications

Journal

TITLE

Chromatographia

ISSUE

4

VOLUME

80

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10337-017-3244-z

DOI

http://dx.doi.org/10.1007/s10337-017-3244-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1054007190


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