Simultaneous Determination of Escin Ia and Its Isomer Isoescin Ia by LC–MS–MS: Application to a Pharmacokinetic Study of Escin Ia ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-08

AUTHORS

Mengliang Zhang, Xiujun Wu, Xiangyong Cui, Feng Gao, Chao Zhang, Yan Yang, Jingkai Gu

ABSTRACT

A rapid and sensitive LC–MS–MS method for the simultaneous determination of escin Ia and isoescin Ia in rat plasma, urine, feces and bile samples was developed and validated. Analytes and telmisartan [internal standard (IS)] were extracted by solid-phase extraction on C18 cartridges. Components in the extract were separated on an HC-C18 column (5 μm, 150 × 4.6 mm i.d.) using 10 mM ammonium acetate–methanol–acetonitrile (40:30:30, v/v/v) as the mobile phase. The method demonstrated good linearity from 5 ng mL−1 (LLOQ) to 1,500 ng mL−1 for both escin Ia and isoescin Ia. Intra- and inter-day precision measured as RSD was within ±15%. Recoveries and matrix effects of both escin Ia and isoescin Ia were satisfactory in all four matrices examined. The method was successfully applied to a pharmacokinetic study in Wistar rats after a single intravenous administration of escin Ia at the dose of 1.0 mg kg−1. More... »

PAGES

243-250

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10337-011-2053-z

DOI

http://dx.doi.org/10.1007/s10337-011-2053-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039313132


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