LC–MS–MS Determination of Troxerutin in Plasma and Its Application to a Pharmacokinetic Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-01

AUTHORS

Xiangyong Cui, Mengliang Zhang, Xin Guan, Lei Yin, Yantong Sun, J. Paul Fawcett, Jingkai Gu

ABSTRACT

A highly sensitive liquid chromatography–tandem mass spectrometry (LC–MS–MS) method for the determination of troxerutin in human plasma using tramadol as internal standard (IS) has been developed and validated. Sample preparation involved liquid–liquid extraction with ethyl acetate–isopropanol (95:5, v/v). The analyte and IS were separated by RP–LC with gradient elution using 10 mM ammonium acetate containing 0.1% formic acid and methanol at a flow rate of 0.9 mL min−1. LC–MS–MS in the positive ion mode employed multiple reaction monitoring of the transitions at m/z 743.2→435.3 and m/z 264.1→58.0 for troxerutin and IS, respectively. The assay was linear in the concentration range 0.01–10 ng mL−1 with precision and accuracy within assay variability limits as per FDA guidelines. The assay was successfully applied to a pharmacokinetic study involving oral administration of 300 mg troxerutin to eight healthy Chinese volunteers. More... »

PAGES

165-169

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10337-010-1827-z

DOI

http://dx.doi.org/10.1007/s10337-010-1827-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046164478


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