Quantitative pulsed CEST-MRI at a clinical 3T MRI system View Full Text


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Article Info

DATE

2017-05-31

AUTHORS

Julia Stabinska, Tom Cronenberg, Hans-Jörg Wittsack, Rotem Shlomo Lanzman, Anja Müller-Lutz

ABSTRACT

ObjectivesThe goal of this study was to quantify CEST related parameters such as chemical exchange rate and fractional concentration of exchanging protons at a clinical 3T scanner. For this purpose, two CEST quantification approaches—the AREX metric (for ‘apparent exchange dependent relaxation’), and the AREX-based Ω-plot method were used. In addition, two different pulsed RF irradiation schemes, using Gaussian-shaped and spin-lock pulses, were compared.Materials and methodsNumerical simulations as well as MRI measurements in phantoms were performed. For simulations, the Bloch–McConnell equations were solved using a two-pool exchange model. MR experiments were performed on a clinical 3T MRI scanner using a cylindrical phantom filled with creatine solution at different pH values and different concentrations.ResultsThe validity of the Ω-plot method and the AREX approach using spin-lock preparation for determination of the quantitative CEST parameters was demonstrated. Especially promising results were achieved for the Ω-plot method when the spin-lock preparation was employed.ConclusionPulsed CEST at 3T could be used to quantify parameters such as exchange rate constants and concentrations of protons exchanging with free water. In the future this technique might be used to estimate the exchange rates and concentrations of biochemical substances in human tissues in vivo. More... »

PAGES

505-516

References to SciGraph publications

  • 2014-02-26. Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner in MAGNETIC RESONANCE MATERIALS IN PHYSICS, BIOLOGY AND MEDICINE
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    http://scigraph.springernature.com/pub.10.1007/s10334-017-0625-0

    DOI

    http://dx.doi.org/10.1007/s10334-017-0625-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085727859

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28569374


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