High resolution single-shot EPI at 7T View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-03

AUTHORS

Oliver Speck, J. Stadler, M. Zaitsev

ABSTRACT

OBJECTIVE: Single-shot echo planar imaging (EPI) acquisitions at 7T are challenging due to increased distortions, signal dropouts, RF-power requirements, and reduced T2*. This study developed and tested pulse sequence and protocol modifications required to allow high resolution EPI for whole brain functional neuroimaging. MATERIALS AND METHODS: Using geometric distortion correction methods, modified fat saturation, and parallel imaging, we acquired high resolution single-shot gradient-echo EPI data at 7T with different spatial resolution. The BOLD sensitivity was evaluated and quantified in a breath hold experiment. RESULTS: Single-shot EPI data with isotropic resolution from 3 to 1.1 mm were acquired in human subjects. The RF-power deposition has been reduced to allow up to 22 slices per second. In addition, acoustic noise and helium boil-off have been reduced. A reduction of the fat saturation flip angle resulted in up to 20% signal gain without compromising the fat suppression quality. For the coil used, the BOLD sensitivity is highest for 2 or 1.4 mm isotropic resolution. CONCLUSION: High resolution single-shot EPI in the whole brain can be performed at 7T with high efficiency, low signal dropout, and without major geometric distortions. More... »

PAGES

73

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10334-007-0087-x

DOI

http://dx.doi.org/10.1007/s10334-007-0087-x

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17973132


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57 schema:description OBJECTIVE: Single-shot echo planar imaging (EPI) acquisitions at 7T are challenging due to increased distortions, signal dropouts, RF-power requirements, and reduced T2*. This study developed and tested pulse sequence and protocol modifications required to allow high resolution EPI for whole brain functional neuroimaging. MATERIALS AND METHODS: Using geometric distortion correction methods, modified fat saturation, and parallel imaging, we acquired high resolution single-shot gradient-echo EPI data at 7T with different spatial resolution. The BOLD sensitivity was evaluated and quantified in a breath hold experiment. RESULTS: Single-shot EPI data with isotropic resolution from 3 to 1.1 mm were acquired in human subjects. The RF-power deposition has been reduced to allow up to 22 slices per second. In addition, acoustic noise and helium boil-off have been reduced. A reduction of the fat saturation flip angle resulted in up to 20% signal gain without compromising the fat suppression quality. For the coil used, the BOLD sensitivity is highest for 2 or 1.4 mm isotropic resolution. CONCLUSION: High resolution single-shot EPI in the whole brain can be performed at 7T with high efficiency, low signal dropout, and without major geometric distortions.
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