The expression and clinical significance of β-catenin and colorectal cancer stem cells marker EpCAMhigh/CD44+ in colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12-19

AUTHORS

Dan Liu, Jinghua Sun, Jinming Zhu, Huan Zhou, Yang Zhang

ABSTRACT

ObjectiveThe aim of the study was to explore the role of Wnt/β-catenin signalling pathway in the maintenance, invasion and metastasis of colorectal cancer stem cells.MethodsDouble immunohistochemical staining was used to detect the expression of EpCAMhigh/CD44+ which is regarded as the marker of colorectal cancer stem cells in 80 cases of colorectal cancer and their corresponding liver metastases. The SP method of immunohistochemistry was used to detect the expression of the key protein β-catenin in the Wnt pathway in these tissue. The expression and correlation of β-catenin and EpCAMhigh/CD44+ in colorectal cancer were analyzed and their role on the biological behavior of colorectal cancer was explored.ResultsThe abnormal expression of β-catenin was significantly higher in colorectal cancer than in the paraneoplastic normal intestinal mucosa [55% (44/80) vs 10% (2/20), P < 0.05]. The positive expression of EpCAMhigh/CD44+ was significantly higher in colorectal cancer than in the paraneoplastic normal intestinal mucosa [66.25% (53/80) vs 0% (0/20), P < 0.05]. In the 80 cases of colorectal cancer, the abnormal expression of β-catenin has no correlation with gender (P = 0.079), age (P = 0.416) and the magnitude (P = 0.816) of the tumor (P > 0.05), but it was significantly correlated with degree of differentiation (P = 0.001), depth of invasion (P = 0.001), clinical stage (P = 0.000) and metastasis (P = 0.000). In the colorectal cancer, the expression of EpCAMhigh/CD44+ cells has no correlation with gender (P = 0.934) and the magnitude (P = 0.160) of the tumor (P > 0.05), but was significantly correlated with age (P = 0.021), degree of differentiation (P = 0.013), depth of invasion (P = 0.000), clinical stage (P = 0.000) and metastasis (P = 0.000). In the corresponding liver metastases, we could also detecte EpCAMhigh/CD44+ cells. In cases with abnormal expression of β-catenin, the positive expression rate of EpCAMhigh/CD44+ was significantly higher than those with normal expression of β-catenin (84.1% vs 44.4%), and the difference was statistically significant (P < 0.05).ConclusionThe abnormal activation of Wnt/β-catenin signalling pathway may prompt the abnormal proliferation of the colorectal cancer stem cells, which leads to the recurrence and metastasis of the cancer. More... »

PAGES

581-585

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10330-013-1258-z

DOI

http://dx.doi.org/10.1007/s10330-013-1258-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016059508


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