Endostar enhances anti-tumor effects of radiation via inhibition of HIF-1α and bFGF in lung adenocarcinoma cell line A549 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12-19

AUTHORS

Huilin Xu, Wei Ge, Fangfang Jie, Dedong Cao, Pingpo Ming, Wei Luo, Jing Song, Changhu Li

ABSTRACT

ObjectiveThe aim of the study was to investigate whether enhanced anti-tumor effects of endostar (ES) on radiation involved hypoxia inducible factor-1α (HIF-1α) and basic fibroblast growth factor (bFGF).MethodsA549 cells were divided into four groups: control group; endostar (ES) group; radiation (RT) group; endostar plus radiation (ES + RT) group. The inhibition of proliferation rates of A549 cells was measured by cell counting kit-8 (CCK-8). HIF-1α and bFGF expression levels were checked by enzyme linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR).ResultsThe proliferation inhibition rate in the ES + RT group was higher than that in other groups. On the other hand, the expressions of HIF-1α and bFGF in the ES + RT group were significantly reduced compared to other groups. HIF-1α and bFGF levels were positively correlated (r = 0.80, P < 0.01).ConclusionOur results suggest that endostar could enhance anti-tumor effect of radiation by reducing expressions of HIF-1α and bFGF. More... »

PAGES

559-563

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10330-013-1255-2

DOI

http://dx.doi.org/10.1007/s10330-013-1255-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050736785


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