Clinical study of docetaxel combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12-19

AUTHORS

Wei Luo, Wei Ge, Yongfa Zheng, Xianfeng Pan, Jing Song, Huilin Xu, Pingpo Ming

ABSTRACT

ObjectiveThe aim of this study was to study the short-term curative effects and adverse reactions of docetaxel (DOC) in concurrent chemoradiotherapy compared to DDP plus 5-Fu (DF) combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma.MethodsThirty-three patients in the experimental group (DOC group) were given DOC 25 mg/m2 ivgtt, d1, 7 times, concurrent radiotherapy was performed from d1. Thirty-three patients in the control group (DF group) were given cisplatin 25 mg/m2 ivgtt d1-3 and 5-Fu 550 mg/m2 iv, d1-5, 3 weeks a cycle, 2 cycles, and concurrent radiotherapy was performed from d1. Six MV X-ray and 9 MeV electronic line for external irradiation were adopted in concurrent radiotherapy.ResultsThe response rates of DOC group and DF group were 90.9% and 93.9%, the rates of neutropenia were 45.45% and 67.74%, and the rates of oral mucositis were 60.61% and 90.32%.ConclusionThe difference of short-term curative effects between DOC group and DF group was not statistically significant in patients with advanced nasopharyngeal carcinoma. The rates of adverse reactions were lower in DOC group. DOC combined with concurrent radiotherapy could be a new choice for patients with advanced nasopharyngeal carcinoma. More... »

PAGES

592-595

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10330-013-1252-5

DOI

http://dx.doi.org/10.1007/s10330-013-1252-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048798569


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