Expression of HIF-1α in hepatocellular carcinoma and its relationship with vasculogenic mimicry and clinical pathology View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11

AUTHORS

Xiaojie Ma, Jie Li, Bangxian Tan

ABSTRACT

ObjectiveThe aim of this study was to discuss HIF-1α expression and vasculogenic mimicry (VM) in hepatocellular carcinoma (HCC) and their relationship with the clinical pathological features and clinical significance.MethodsTwo hundred and seven specimens from patients in The Affiliated Hospital of North Sichuan Medical College who received hepatic cell carcinoma resection were tested by immunohistochemistry and double staining of CD31 and PSA. Then detected the expression of HIF-1α, VM, and analysed the relationship between clinical pathology.ResultsThe HIF-1α positive rate was 71.01% and its expression was associated with liver cirrhosis, tumor size and TNM stage (P < 0.05). HIF-1α protein expression was positively associated with the VM (γ = 0.1988, P = 0.0041).ConclusionHypoxia may be the reason for VM in high invasive HCC, regulating the tumor microenvironment may have great significance in inhibiting invasion and metastasis of HCC. More... »

PAGES

528-531

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10330-013-1217-8

DOI

http://dx.doi.org/10.1007/s10330-013-1217-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006154823


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