Pancreatic cancer — Adjuvant therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04-01

AUTHORS

Asma Sultana, John Neoptolemos, Paula Ghaneh

ABSTRACT

Pancreatic cancer ranks tenth in terms of newly diagnosed cases, but just 10%–15% of these patients can undergo resection. Survival after curative surgery is dismal, as recurrences occur either locally or in the liver. Adjuvant treatment with either chemotherapy or chemoradiation (with or without maintenance chemotherapy) has been employed, to improve the poor prognosis. Justification for the use of chemoradiation, with follow on chemotherapy, is based on the results of an underpowered 1987 GITSG study, which closed prematurely and compared intervention to observation. There has been no survival advantage demonstrated in the one randomized controlled trial that examined chemoradiation compared to chemotherapy. There is a clear cut survival advantage however with chemotherapy compared to observation, based on the results from two large randomized controlled trials, and supported by an individual patient data meta-analysis. The standard of care for adjuvant therapy based on level I evidence (from the ESPAC-1 trial) is post operative chemotherapy using 5-Fluorouracil with folinic acid providing a best estimate of 29% five years survival. More... »

PAGES

170-175

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10330-007-0047-y

DOI

http://dx.doi.org/10.1007/s10330-007-0047-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025712702


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sultana", 
        "givenName": "Asma", 
        "id": "sg:person.01246775112.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246775112.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neoptolemos", 
        "givenName": "John", 
        "id": "sg:person.0750565077.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750565077.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghaneh", 
        "givenName": "Paula", 
        "id": "sg:person.07372440237.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07372440237.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02924237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078215791", 
          "https://doi.org/10.1007/bf02924237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ijgc:27:3:217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013651129", 
          "https://doi.org/10.1385/ijgc:27:3:217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002689900215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050456898", 
          "https://doi.org/10.1007/s002689900215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002689900604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006562316", 
          "https://doi.org/10.1007/s002689900604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-005-0539-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011385152", 
          "https://doi.org/10.1007/s10552-005-0539-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02924238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077938662", 
          "https://doi.org/10.1007/bf02924238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015676534", 
          "https://doi.org/10.1038/sj.bjc.6602513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-5-37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027053207", 
          "https://doi.org/10.1186/1471-2407-5-37"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-04-01", 
    "datePublishedReg": "2007-04-01", 
    "description": "Pancreatic cancer ranks tenth in terms of newly diagnosed cases, but just 10%\u201315% of these patients can undergo resection. Survival after curative surgery is dismal, as recurrences occur either locally or in the liver. Adjuvant treatment with either chemotherapy or chemoradiation (with or without maintenance chemotherapy) has been employed, to improve the poor prognosis. Justification for the use of chemoradiation, with follow on chemotherapy, is based on the results of an underpowered 1987 GITSG study, which closed prematurely and compared intervention to observation. There has been no survival advantage demonstrated in the one randomized controlled trial that examined chemoradiation compared to chemotherapy. There is a clear cut survival advantage however with chemotherapy compared to observation, based on the results from two large randomized controlled trials, and supported by an individual patient data meta-analysis. The standard of care for adjuvant therapy based on level I evidence (from the ESPAC-1 trial) is post operative chemotherapy using 5-Fluorouracil with folinic acid providing a best estimate of 29% five years survival.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10330-007-0047-y", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1032171", 
        "issn": [
          "1610-1979", 
          "1613-9089"
        ], 
        "name": "The Chinese-German Journal of Clinical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "survival advantage", 
      "post-operative chemotherapy", 
      "cancer adjuvant therapy", 
      "use of chemoradiation", 
      "standard of care", 
      "individual patient data", 
      "curative surgery", 
      "GITSG study", 
      "operative chemotherapy", 
      "adjuvant treatment", 
      "adjuvant therapy", 
      "poor prognosis", 
      "folinic acid", 
      "pancreatic cancer", 
      "year survival", 
      "Level I", 
      "chemotherapy", 
      "chemoradiation", 
      "patient data", 
      "therapy", 
      "trials", 
      "survival", 
      "resection", 
      "patients", 
      "surgery", 
      "recurrence", 
      "prognosis", 
      "follow", 
      "cancer", 
      "liver", 
      "care", 
      "intervention", 
      "treatment", 
      "cases", 
      "study", 
      "acid", 
      "results", 
      "use", 
      "data", 
      "observations", 
      "standards", 
      "advantages", 
      "best estimate", 
      "estimates", 
      "terms", 
      "justification"
    ], 
    "name": "Pancreatic cancer \u2014 Adjuvant therapy", 
    "pagination": "170-175", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025712702"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10330-007-0047-y"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10330-007-0047-y", 
      "https://app.dimensions.ai/details/publication/pub.1025712702"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_443.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10330-007-0047-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10330-007-0047-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10330-007-0047-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10330-007-0047-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10330-007-0047-y'


 

This table displays all metadata directly associated to this object as RDF triples.

149 TRIPLES      21 PREDICATES      78 URIs      62 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10330-007-0047-y schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nbbb41cb0e3b44b6db746c2b55821ee96
4 schema:citation sg:pub.10.1007/bf02924237
5 sg:pub.10.1007/bf02924238
6 sg:pub.10.1007/s002689900215
7 sg:pub.10.1007/s002689900604
8 sg:pub.10.1007/s10552-005-0539-4
9 sg:pub.10.1038/sj.bjc.6602513
10 sg:pub.10.1186/1471-2407-5-37
11 sg:pub.10.1385/ijgc:27:3:217
12 schema:datePublished 2007-04-01
13 schema:datePublishedReg 2007-04-01
14 schema:description Pancreatic cancer ranks tenth in terms of newly diagnosed cases, but just 10%–15% of these patients can undergo resection. Survival after curative surgery is dismal, as recurrences occur either locally or in the liver. Adjuvant treatment with either chemotherapy or chemoradiation (with or without maintenance chemotherapy) has been employed, to improve the poor prognosis. Justification for the use of chemoradiation, with follow on chemotherapy, is based on the results of an underpowered 1987 GITSG study, which closed prematurely and compared intervention to observation. There has been no survival advantage demonstrated in the one randomized controlled trial that examined chemoradiation compared to chemotherapy. There is a clear cut survival advantage however with chemotherapy compared to observation, based on the results from two large randomized controlled trials, and supported by an individual patient data meta-analysis. The standard of care for adjuvant therapy based on level I evidence (from the ESPAC-1 trial) is post operative chemotherapy using 5-Fluorouracil with folinic acid providing a best estimate of 29% five years survival.
15 schema:genre article
16 schema:isAccessibleForFree false
17 schema:isPartOf N0dce01313cc54885ba7d48f73b9cd680
18 Ncd6c86728b234ece88a16cc5f8cbff6a
19 sg:journal.1032171
20 schema:keywords GITSG study
21 Level I
22 acid
23 adjuvant therapy
24 adjuvant treatment
25 advantages
26 best estimate
27 cancer
28 cancer adjuvant therapy
29 care
30 cases
31 chemoradiation
32 chemotherapy
33 curative surgery
34 data
35 estimates
36 folinic acid
37 follow
38 individual patient data
39 intervention
40 justification
41 liver
42 observations
43 operative chemotherapy
44 pancreatic cancer
45 patient data
46 patients
47 poor prognosis
48 post-operative chemotherapy
49 prognosis
50 recurrence
51 resection
52 results
53 standard of care
54 standards
55 study
56 surgery
57 survival
58 survival advantage
59 terms
60 therapy
61 treatment
62 trials
63 use
64 use of chemoradiation
65 year survival
66 schema:name Pancreatic cancer — Adjuvant therapy
67 schema:pagination 170-175
68 schema:productId N56e3390dff7d47e7a9a76d2a4f539e55
69 Ncf6179136ca84c438ff832a9919ef1ef
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025712702
71 https://doi.org/10.1007/s10330-007-0047-y
72 schema:sdDatePublished 2022-09-02T15:53
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nb3f5cb34bd394cd28e71b4e65b907c1f
75 schema:url https://doi.org/10.1007/s10330-007-0047-y
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0dce01313cc54885ba7d48f73b9cd680 schema:issueNumber 2
80 rdf:type schema:PublicationIssue
81 N3b5bcfc706ed4249ba71595e71100d3f rdf:first sg:person.07372440237.86
82 rdf:rest rdf:nil
83 N56e3390dff7d47e7a9a76d2a4f539e55 schema:name dimensions_id
84 schema:value pub.1025712702
85 rdf:type schema:PropertyValue
86 N83233fbaa14b4f1ca3454fd864c5f43f rdf:first sg:person.0750565077.18
87 rdf:rest N3b5bcfc706ed4249ba71595e71100d3f
88 Nb3f5cb34bd394cd28e71b4e65b907c1f schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 Nbbb41cb0e3b44b6db746c2b55821ee96 rdf:first sg:person.01246775112.38
91 rdf:rest N83233fbaa14b4f1ca3454fd864c5f43f
92 Ncd6c86728b234ece88a16cc5f8cbff6a schema:volumeNumber 6
93 rdf:type schema:PublicationVolume
94 Ncf6179136ca84c438ff832a9919ef1ef schema:name doi
95 schema:value 10.1007/s10330-007-0047-y
96 rdf:type schema:PropertyValue
97 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
98 schema:name Medical and Health Sciences
99 rdf:type schema:DefinedTerm
100 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
101 schema:name Oncology and Carcinogenesis
102 rdf:type schema:DefinedTerm
103 sg:journal.1032171 schema:issn 1610-1979
104 1613-9089
105 schema:name The Chinese-German Journal of Clinical Oncology
106 schema:publisher Springer Nature
107 rdf:type schema:Periodical
108 sg:person.01246775112.38 schema:affiliation grid-institutes:grid.10025.36
109 schema:familyName Sultana
110 schema:givenName Asma
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246775112.38
112 rdf:type schema:Person
113 sg:person.07372440237.86 schema:affiliation grid-institutes:grid.10025.36
114 schema:familyName Ghaneh
115 schema:givenName Paula
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07372440237.86
117 rdf:type schema:Person
118 sg:person.0750565077.18 schema:affiliation grid-institutes:grid.10025.36
119 schema:familyName Neoptolemos
120 schema:givenName John
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750565077.18
122 rdf:type schema:Person
123 sg:pub.10.1007/bf02924237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078215791
124 https://doi.org/10.1007/bf02924237
125 rdf:type schema:CreativeWork
126 sg:pub.10.1007/bf02924238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077938662
127 https://doi.org/10.1007/bf02924238
128 rdf:type schema:CreativeWork
129 sg:pub.10.1007/s002689900215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050456898
130 https://doi.org/10.1007/s002689900215
131 rdf:type schema:CreativeWork
132 sg:pub.10.1007/s002689900604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006562316
133 https://doi.org/10.1007/s002689900604
134 rdf:type schema:CreativeWork
135 sg:pub.10.1007/s10552-005-0539-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011385152
136 https://doi.org/10.1007/s10552-005-0539-4
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/sj.bjc.6602513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015676534
139 https://doi.org/10.1038/sj.bjc.6602513
140 rdf:type schema:CreativeWork
141 sg:pub.10.1186/1471-2407-5-37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027053207
142 https://doi.org/10.1186/1471-2407-5-37
143 rdf:type schema:CreativeWork
144 sg:pub.10.1385/ijgc:27:3:217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013651129
145 https://doi.org/10.1385/ijgc:27:3:217
146 rdf:type schema:CreativeWork
147 grid-institutes:grid.10025.36 schema:alternateName Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK
148 schema:name Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, L69 3GA, Liverpool, UK
149 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...