Embryotransfer an Tag 2/3 vs. Tag 5/6 und „time-lapse imaging“ View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-26

AUTHORS

Jens Erik Dietrich, Thomas Strowitzki

ABSTRACT

BackgroundThe goal of medically assisted reproduction (MAR) is the birth of a healthy child. The effectiveness and compatibility of MAR are of central importance and affect the treatment strategy. In general, the clinical results after MAR are associated with an increased risk for perinatal complications. The main risk is multifetal gestations; to reduce these, transfer of a single embryo is recommended. To enable high effectiveness, an assessment of embryo developmental capacity is of the utmost importance. Here, extended in vitro culture until the formation of a blastocyst is of special interest. However, the transfer of a blastocyst on day 5/6 is associated with an increased risk for perinatal complications compared to the transfer of a cleavage stage embryo on day 2/3. Therefore, the decision on treatment strategy requires that effectiveness be weighed against the risks.ObjectivesOverview of risks and benefits of the in vitro culture of human embryos up to day 5/6 compared to day 2/3 embryo transfers in MAR.ConclusionThe decision regarding transfer on day 2/3 or on day 5/6 is complex. To minimize perinatal risks, multifetal gestation should be avoided in both cases. The most effective way to do this is to perform single embryo transfers. Additional perinatal risks after extended in vitro culture are possibly due to in vitro culture conditions and/or current selection criteria, both for the patient collective and the embryos to be transferred. When assessing the efficacy of MAR treatment, there is no apparent cumulative difference in pregnancy rates and live birth rates between treatment involving transfer on day 2/3 or on day 5/6. More... »

PAGES

1-6

References to SciGraph publications

  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2017-08-29. Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro in SCIENTIFIC REPORTS
  • 2015-12-02. High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos in SCIENTIFIC REPORTS
  • 2015-01-11. Is it time for a paradigm shift in understanding embryo selection? in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
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    http://scigraph.springernature.com/pub.10.1007/s10304-021-00422-6

    DOI

    http://dx.doi.org/10.1007/s10304-021-00422-6

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