An integrated biotechnology platform for developing sustainable chemical processes View Full Text


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Article Info

DATE

2015-03

AUTHORS

Nelson R. Barton, Anthony P. Burgard, Mark J. Burk, Jason S. Crater, Robin E. Osterhout, Priti Pharkya, Brian A. Steer, Jun Sun, John D. Trawick, Stephen J. Van Dien, Tae Hoon Yang, Harry Yim

ABSTRACT

Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process. More... »

PAGES

349-360

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10295-014-1541-1

DOI

http://dx.doi.org/10.1007/s10295-014-1541-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014424105

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25416472


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