Adaptive response of yeasts to furfural and 5-hydroxymethylfurfural and new chemical evidence for HMF conversion to 2,5-bis-hydroxymethylfuran View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-09

AUTHORS

Z. L. Liu, P. J. Slininger, B. S. Dien, M. A. Berhow, C. P. Kurtzman, S. W. Gorsich

ABSTRACT

Renewable lignocellulosic materials are attractive low-cost feedstocks for bioethanol production. Furfural and 5-hydroxymethylfurfural (HMF) are among the most potent inhibitory compounds generated from acid hydrolysis of lignocelluloses to simple sugars for fermentation. In Saccharomyces cerevisiae ATCC 211239 and NRRL Y-12632 and Pichia stipitis NRRL Y-7124, furfural and HMF inhibition were determined to be dose-dependent at concentrations from 10 to 120 mM. The yeast strains were more sensitive to inhibition by furfural than HMF at the same concentration, while combined treatment of furfural and HMF synergistically suppressed cell growth. A metabolite transformed from HMF by strain NRRL Y-12632 was isolated from the culture supernatant, and conclusively identified as 2,5-bis-hydroxymethylfuran, a previously postulated HMF alcohol, with a composition of C6H8O3 and a molecular weight of 128. It is proposed that, in the presence of HMF, the yeast reduces the aldehyde group on the furan ring of HMF into an alcohol, in a similar manner as for furfural. The accumulation of this biotransformed metabolite may be less toxic to yeast cultures than HMF, as evidenced by the rapid yeast fermentation and growth rates associated with HMF conversion. The ability of yeasts to adapt to and transform furfural and HMF offers the potential for in situ detoxification of these inhibitors and suggests a genetic basis for further development of highly tolerant strains for biofuel production. More... »

PAGES

345-352

References to SciGraph publications

  • 2001-01-30. Genetic Engineering for Improved Xylose Fermentation by Yeasts in RECENT PROGRESS IN BIOCONVERSION OF LIGNOCELLULOSICS
  • 2001-08-30. Metabolic Engineering of Saccharomyces cerevisiae for Xylose Utilization in METABOLIC ENGINEERING
  • 1993-05. Biotransformation of furfural and 5-hydroxymethyl furfural by enteric bacteria in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2000-06. Physiological effects of 5-hydroxymethylfurfural on Saccharomyces cerevisiae in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10295-004-0148-3

    DOI

    http://dx.doi.org/10.1007/s10295-004-0148-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011965280

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15338422


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