Particularités génétiques et épidémiologiques des tumeurs urothéliales de la voie excrétrice supérieure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-04

AUTHORS

M. Rouprêt, P. Colin

ABSTRACT

Le butétait de décrire l’histoire naturelle et les particularités de la carcinogenèse des tumeurs de la voie excrétrice urinaire supérieure (TVES). Une revue de la littérature sur Medline a été réalisée en considérant l’ensemble des articles répertoriés jusqu’en 2014 et en utilisant différentes combinaisons des mots clés suivant: carcinome urothélial; clonalité; carcinogenèse; mutations; instabilité chromosomique; syndrome de Lynch; polymorphisme génétique; épidémiologie; facteurs de risque; tabac; acide aristolochique (AcA); uretère; bassinet. La carcinogenèse des TVES et des tumeurs de vessie présente d’importantes bases communes dont l’implication de la mutation du proto-oncogène FGFR3. Plusieurs facteurs de risque génétiques spécifiques aux TVES non établis dans les tumeurs de la vessie comme le syndrome de Lynch ou certains polymorphismes génétiques ont également été mis en évidence expliquant ainsi la susceptibilité de certains individus à développer ce type de tumeurs. L’incidence estimée des TVES est de 1,2 cas pour 100 000 habitants par an en Europe. L’incidence des tumeurs pyélocalicielles est stable depuis 30 ans, alors que la fréquence des localisations urétérales est en augmentation avec le temps. Les stades et grades avancés seraient plus fréquents au diagnostic. Celuici aurait lieu à un âge moyen plus tardif (> 70 ans). Le ratio homme/femme est de l’ordre de 2. Les principaux carcinogènes de l’urothélium restent le tabac et l’exposition professionnelle. Il existe des facteurs environnementaux spécifiques aux TVES. L’exposition à l’AcA (néphropathie des Balkans et herbes chinoises) est à l’origine d’une carcinogenèse spécifique du haut appareil urinaire. More... »

PAGES

184-190

Journal

TITLE

Oncologie

ISSUE

4

VOLUME

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10269-015-2506-3

DOI

http://dx.doi.org/10.1007/s10269-015-2506-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016089176


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