Ontology type: schema:ScholarlyArticle
2010-07
AUTHORSF. Reyal, M. -A. Bollet, G. Roubaud, A. Vincent-Salomon, R. -J. Salmon
ABSTRACTDepuis plus de dix ans, le développement continu de nouvelles technologies d’analyse à haut débit offre aux scientifiques la possibilité d’étudier la biologie du vivant en général et des cancers en particulier par des voies aussi différentes que complémentaires. Ainsi, les altérations de la structure de l’ADN (amplification, délétion, gain), les pertes d’hétérozygotie (LOH), les altérations du niveau d’expression des gènes, les altérations du contrôle posttranscriptionnelle des microARN, l’activation des complexes protéiques peuvent être analysées simultanément à l’échelle du génome humain. Nous présentons ici un résumé des découvertes obtenues par l’analyse à haut débit du profil d’expression des cancers du sein, en insistant particulièrement sur l’impact majeur de ces travaux sur la connaissance et la prise en charge clinique de ces patientes. Les terabytes de données biologiques accumulées par les scientifiques depuis plus de dix ans ne répondent pas simplement à une lubie technologique mais sont au contraire des outils déterminants de la dissection moderne de ces tumeurs. L’amélioration du pronostic des patientes atteintes de cancer du sein passe nécessairement par l’utilisation de ces technologies. More... »
PAGES396-402
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