Ontology type: schema:ScholarlyArticle
2010-04
AUTHORSF. Reyal, J. -Y. Pierga, R. -J. Salmon, A. Vincent-Salomon, M. -A. Bollet
ABSTRACTLes critères usuels cliniques et pathologiques ne permettent pas de définir précisément le pronostic individuel des patientes traitées pour cancer du sein et entraînent un « surtraitement » adjuvant d’un grand nombre d’entre elles. Trois outils fondés sur l’expression génique, à moyen ou haut débit, ont été développés pour tenter de pallier cette imprécision. Leurs validations sur des séries indépendantes ont abouti à leur développement commercial. Les études sont en cours pour savoir dans quelle mesure ces signatures génomiques apportent un bénéfice cliniquement perceptible en termes de pronostic et de meilleure indication thérapeutique. Ces signatures moléculaires de première génération reposent essentiellement dans leur composition sur les voies des récepteurs aux estrogènes, du gène HER2 et de la prolifération. Il reste à démontrer qu’une utilisation de marqueurs immunohistochimiques de routine, correctement calibrés et combinés n’apporte pas une information équivalente. More... »
PAGES263-268
http://scigraph.springernature.com/pub.10.1007/s10269-010-1876-9
DOIhttp://dx.doi.org/10.1007/s10269-010-1876-9
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