Elevation of human leukocyte antigen-G expression is associated with the severe encephalitis associated with neurogenic pulmonary edema caused by Enterovirus ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

Xiao-Qun Zheng, Xiao-Qing Chen, Yan Gao, Miao Fu, Yi-Ping Chen, Dan-Ping Xu, Aifen Lin, Wei-Hua Yan

ABSTRACT

Enterovirus 71 (EV71) infection can develop devastating clinical outcomes such as brain stem encephalitis (BE) and pulmonary edema (PE). Alteration of human leukocyte antigen-G (HLA-G) expression or cytokine production was considered playing important roles in virus-related pathogenesis. However, clinical relevance of HLA-G in EV71 infection remains unknown. In the current study, patients were stratified by disease severity as BE (n = 107) and PE (n = 18). HLA-G expression on peripheral blood monocytes from patients with BE (n = 15), patients with PE (n = 15) and control subjects (n = 31) was analyzed with flow cytometry. Plasma soluble HLA-G (sHLA-G) (in 67 BE, 18 PE and 120 control subjects), IL-6 and IL-10 (in 50 patients with BE, 18 patients with PE and 45 control subjects) were determined with enzyme-linked immunosorbent assay. Data showed that the percentage of HLA-G-positive monocytes (mean 7.76 vs 3.68 %, p < 0.001), levels for sHLA-G (median 129.2 vs 70.6 U/ml, p < 0.001), IL-10 (median 160.5 vs 29.5 pg/ml, p < 0.001) and IL-6 (median 20.50 vs 5.21 pg/ml, p = 0.002) was significantly higher in patients with PE than in patients with BE. Taken together, our findings indicated that elevation of HLA-G expression on monocytes, plasma sHLA-G, IL-10 and IL-6 levels was associated with PE in patients infected with EV71. More... »

PAGES

161-167

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10238-013-0237-6

DOI

http://dx.doi.org/10.1007/s10238-013-0237-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022392452

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23605689


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Encephalitis, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterovirus A, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterovirus Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-G Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes, Mononuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Edema", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Department of the Laboratory Medicine, the Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Xiao-Qun", 
        "id": "sg:person.01071035727.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071035727.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Department of the Laboratory Medicine, the Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xiao-Qing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Department of the Laboratory Medicine, the Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Yan", 
        "id": "sg:person.01105640374.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105640374.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Department of the Laboratory Medicine, the Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Miao", 
        "id": "sg:person.01037525174.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037525174.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Department of the Infectious Diseases, the YuYin Children Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yi-Ping", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Dan-Ping", 
        "id": "sg:person.01155310524.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155310524.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Aifen", 
        "id": "sg:person.01041062124.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041062124.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Wei-Hua", 
        "id": "sg:person.01206356160.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206356160.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.humimm.2008.08.280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001201428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2002.tb03292.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002838168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2002.tb03292.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002838168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(10)70194-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004687004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2011.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007988493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-0691.2007.01729.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010791963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2009.00723.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012311656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2009.00723.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012311656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/376998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012374878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2009.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013430113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2893.2010.01286.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019192071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-010-0578-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020376198", 
          "https://doi.org/10.1007/s00018-010-0578-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-010-0581-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022889918", 
          "https://doi.org/10.1007/s00018-010-0581-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2010.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029784148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200202150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029979978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200202150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029979978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01779-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031404743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032277257", 
          "https://doi.org/10.1038/nri2575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032277257", 
          "https://doi.org/10.1038/nri2575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1875-9572(08)60024-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037229789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2009.07.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037422444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micinf.2010.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040295131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0198-8859(00)00197-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041114505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/345905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041834002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2006.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042658556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2007.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045248164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3181a41d63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045308163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3181a41d63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045308163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3181a41d63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045308163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2011.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046052780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.24.15226-15237.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046656597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/591462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047299974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d0825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050887704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d0825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050887704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d0825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050887704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micinf.2010.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051777524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/604733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058809823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/129.3.304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059695291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/eri.09.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068079972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187153011794982059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069223422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.12.6426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074649937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077414321", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077676819", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078336841", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-05", 
    "datePublishedReg": "2014-05-01", 
    "description": "Enterovirus 71 (EV71) infection can develop devastating clinical outcomes such as brain stem encephalitis (BE) and pulmonary edema (PE). Alteration of human leukocyte antigen-G (HLA-G) expression or cytokine production was considered playing important roles in virus-related pathogenesis. However, clinical relevance of HLA-G in EV71 infection remains unknown. In the current study, patients were stratified by disease severity as BE (n\u00a0=\u00a0107) and PE (n\u00a0=\u00a018). HLA-G expression on peripheral blood monocytes from patients with BE (n\u00a0=\u00a015), patients with PE (n\u00a0=\u00a015) and control subjects (n\u00a0=\u00a031) was analyzed with flow cytometry. Plasma soluble HLA-G (sHLA-G) (in 67 BE, 18 PE and 120 control subjects), IL-6 and IL-10 (in 50 patients with BE, 18 patients with PE and 45 control subjects) were determined with enzyme-linked immunosorbent assay. Data showed that the percentage of HLA-G-positive monocytes (mean 7.76 vs 3.68\u00a0%, p\u00a0<\u00a00.001), levels for sHLA-G (median 129.2 vs 70.6\u00a0U/ml, p\u00a0<\u00a00.001), IL-10 (median 160.5 vs 29.5\u00a0pg/ml, p\u00a0<\u00a00.001) and IL-6 (median 20.50 vs 5.21\u00a0pg/ml, p\u00a0=\u00a00.002) was significantly higher in patients with PE than in patients with BE. Taken together, our findings indicated that elevation of HLA-G expression on monocytes, plasma sHLA-G, IL-10 and IL-6 levels was associated with PE in patients infected with EV71. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10238-013-0237-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1027081", 
        "issn": [
          "1591-8890", 
          "1591-9528"
        ], 
        "name": "Clinical and Experimental Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Elevation of human leukocyte antigen-G expression is associated with the severe encephalitis associated with neurogenic pulmonary edema caused by Enterovirus 71", 
    "pagination": "161-167", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6aae79f28078c214210d87041f294d7595d2534c1f864390da148aa1b23ef228"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23605689"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100973405"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10238-013-0237-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022392452"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10238-013-0237-6", 
      "https://app.dimensions.ai/details/publication/pub.1022392452"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000532.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10238-013-0237-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10238-013-0237-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10238-013-0237-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10238-013-0237-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10238-013-0237-6'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      83 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10238-013-0237-6 schema:about N0bcefc7678bf4f89afe0f304661decfa
2 N109e471d07e44671a2c16de3efd93d40
3 N1154d48a308349ee8393151ad66afc7b
4 N19c2bde507bd49ef9507ac642b7f7f03
5 N206861a52446411fb700540ff3390337
6 N314576add2144e94b6724c868619e7d3
7 N4de0f41379724062867b9d41a539f2d2
8 N5b235941e75d42428c09862f85a3d4c3
9 N5fb906ab17114c60a49aba33e0413177
10 N745154df925143ab89c3d28ee9a432eb
11 N8ebb3a8f8dff45dc98ea5e439c73e4a8
12 N9ab516c75cbe46deb243d16ccf639e65
13 Nad8eb919e4a642b49845765f4be8eee9
14 Naf6fe43094234e89b120e81ff5e95a05
15 Ncf353d4108cf40e5b1777ef1b9d52c1c
16 Nd1d6e0713b8d41f49db9d115b3cb7d15
17 Nd5716635fbba410e9d3bcf767ea483af
18 Nea9dff0073ff4094906cbf42c328042c
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author N18372be9ec8b47b69e211377cb14a48d
22 schema:citation sg:pub.10.1007/s00018-010-0578-1
23 sg:pub.10.1007/s00018-010-0581-6
24 sg:pub.10.1038/nri2575
25 https://app.dimensions.ai/details/publication/pub.1077414321
26 https://app.dimensions.ai/details/publication/pub.1077676819
27 https://app.dimensions.ai/details/publication/pub.1078336841
28 https://doi.org/10.1016/j.coph.2009.05.007
29 https://doi.org/10.1016/j.humimm.2006.12.003
30 https://doi.org/10.1016/j.humimm.2008.08.280
31 https://doi.org/10.1016/j.humimm.2009.07.022
32 https://doi.org/10.1016/j.humimm.2010.11.009
33 https://doi.org/10.1016/j.humimm.2011.02.008
34 https://doi.org/10.1016/j.humimm.2011.06.012
35 https://doi.org/10.1016/j.it.2007.11.005
36 https://doi.org/10.1016/j.micinf.2010.03.006
37 https://doi.org/10.1016/j.micinf.2010.07.007
38 https://doi.org/10.1016/s0198-8859(00)00197-x
39 https://doi.org/10.1016/s1473-3099(10)70194-8
40 https://doi.org/10.1016/s1875-9572(08)60024-8
41 https://doi.org/10.1086/345905
42 https://doi.org/10.1086/376998
43 https://doi.org/10.1086/591462
44 https://doi.org/10.1086/604733
45 https://doi.org/10.1093/infdis/129.3.304
46 https://doi.org/10.1097/00002030-200202150-00005
47 https://doi.org/10.1097/inf.0b013e3181a41d63
48 https://doi.org/10.1097/qad.0b013e32832d0825
49 https://doi.org/10.1111/j.1365-2893.2010.01286.x
50 https://doi.org/10.1111/j.1469-0691.2007.01729.x
51 https://doi.org/10.1111/j.1600-0897.2009.00723.x
52 https://doi.org/10.1111/j.1651-2227.2002.tb03292.x
53 https://doi.org/10.1128/jvi.01779-10
54 https://doi.org/10.1128/jvi.79.24.15226-15237.2005
55 https://doi.org/10.1586/eri.09.45
56 https://doi.org/10.2174/187153011794982059
57 https://doi.org/10.4049/jimmunol.164.12.6426
58 schema:datePublished 2014-05
59 schema:datePublishedReg 2014-05-01
60 schema:description Enterovirus 71 (EV71) infection can develop devastating clinical outcomes such as brain stem encephalitis (BE) and pulmonary edema (PE). Alteration of human leukocyte antigen-G (HLA-G) expression or cytokine production was considered playing important roles in virus-related pathogenesis. However, clinical relevance of HLA-G in EV71 infection remains unknown. In the current study, patients were stratified by disease severity as BE (n = 107) and PE (n = 18). HLA-G expression on peripheral blood monocytes from patients with BE (n = 15), patients with PE (n = 15) and control subjects (n = 31) was analyzed with flow cytometry. Plasma soluble HLA-G (sHLA-G) (in 67 BE, 18 PE and 120 control subjects), IL-6 and IL-10 (in 50 patients with BE, 18 patients with PE and 45 control subjects) were determined with enzyme-linked immunosorbent assay. Data showed that the percentage of HLA-G-positive monocytes (mean 7.76 vs 3.68 %, p < 0.001), levels for sHLA-G (median 129.2 vs 70.6 U/ml, p < 0.001), IL-10 (median 160.5 vs 29.5 pg/ml, p < 0.001) and IL-6 (median 20.50 vs 5.21 pg/ml, p = 0.002) was significantly higher in patients with PE than in patients with BE. Taken together, our findings indicated that elevation of HLA-G expression on monocytes, plasma sHLA-G, IL-10 and IL-6 levels was associated with PE in patients infected with EV71.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N630f19371a264572a086e0420551afff
65 Ndb446d089c1946bc9fcb4055dda0e0c1
66 sg:journal.1027081
67 schema:name Elevation of human leukocyte antigen-G expression is associated with the severe encephalitis associated with neurogenic pulmonary edema caused by Enterovirus 71
68 schema:pagination 161-167
69 schema:productId N313b7fb424b44122ae95c9cdd59758e6
70 N8ca08aa3a4b844ebae54d5d9f5d831f5
71 N95e1b178bc4948429d202c773675aafb
72 Nafb0e700b5d646558a67c176f3be4efa
73 Nf74a8fef230f42e49d8aa451313e3144
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022392452
75 https://doi.org/10.1007/s10238-013-0237-6
76 schema:sdDatePublished 2019-04-10T20:01
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nba29d640748e406782ac7df4e9df3d5e
79 schema:url http://link.springer.com/10.1007%2Fs10238-013-0237-6
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N08aa6bbbb5eb4a87ad1862b347fa21b1 rdf:first N5d12a24dd1374fcf9b67e3e86fbd01d5
84 rdf:rest N6024aeae47e449dfaa98b6683021586c
85 N0bcefc7678bf4f89afe0f304661decfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Encephalitis, Viral
87 rdf:type schema:DefinedTerm
88 N109e471d07e44671a2c16de3efd93d40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Enzyme-Linked Immunosorbent Assay
90 rdf:type schema:DefinedTerm
91 N1154d48a308349ee8393151ad66afc7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Severity of Illness Index
93 rdf:type schema:DefinedTerm
94 N18372be9ec8b47b69e211377cb14a48d rdf:first sg:person.01071035727.00
95 rdf:rest N08aa6bbbb5eb4a87ad1862b347fa21b1
96 N19c2bde507bd49ef9507ac642b7f7f03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Pulmonary Edema
98 rdf:type schema:DefinedTerm
99 N202fcfc5103344909bfbecdd8155388a rdf:first Na3fbd46da9c14116a7322eaaafc20a2f
100 rdf:rest N6d89022335f846d3a2f538ee0263ee69
101 N206861a52446411fb700540ff3390337 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Adolescent
103 rdf:type schema:DefinedTerm
104 N313b7fb424b44122ae95c9cdd59758e6 schema:name dimensions_id
105 schema:value pub.1022392452
106 rdf:type schema:PropertyValue
107 N314576add2144e94b6724c868619e7d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Child, Preschool
109 rdf:type schema:DefinedTerm
110 N4de0f41379724062867b9d41a539f2d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Enterovirus A, Human
112 rdf:type schema:DefinedTerm
113 N5b235941e75d42428c09862f85a3d4c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Male
115 rdf:type schema:DefinedTerm
116 N5d12a24dd1374fcf9b67e3e86fbd01d5 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
117 schema:familyName Chen
118 schema:givenName Xiao-Qing
119 rdf:type schema:Person
120 N5fb906ab17114c60a49aba33e0413177 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Flow Cytometry
122 rdf:type schema:DefinedTerm
123 N6024aeae47e449dfaa98b6683021586c rdf:first sg:person.01105640374.38
124 rdf:rest Nd87b9c5a87a24a62b05f2f69dd7c8777
125 N630f19371a264572a086e0420551afff schema:volumeNumber 14
126 rdf:type schema:PublicationVolume
127 N6d89022335f846d3a2f538ee0263ee69 rdf:first sg:person.01155310524.84
128 rdf:rest Nd0076f35d15241df8278a4178cd6c9ca
129 N745154df925143ab89c3d28ee9a432eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name HLA-G Antigens
131 rdf:type schema:DefinedTerm
132 N8ca08aa3a4b844ebae54d5d9f5d831f5 schema:name doi
133 schema:value 10.1007/s10238-013-0237-6
134 rdf:type schema:PropertyValue
135 N8ebb3a8f8dff45dc98ea5e439c73e4a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Interleukin-6
137 rdf:type schema:DefinedTerm
138 N90d156d506fe4b1e9189e1a0d0309823 rdf:first sg:person.01206356160.52
139 rdf:rest rdf:nil
140 N95e1b178bc4948429d202c773675aafb schema:name nlm_unique_id
141 schema:value 100973405
142 rdf:type schema:PropertyValue
143 N9ab516c75cbe46deb243d16ccf639e65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 Na3fbd46da9c14116a7322eaaafc20a2f schema:affiliation https://www.grid.ac/institutes/grid.268099.c
147 schema:familyName Chen
148 schema:givenName Yi-Ping
149 rdf:type schema:Person
150 Nad8eb919e4a642b49845765f4be8eee9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Leukocytes, Mononuclear
152 rdf:type schema:DefinedTerm
153 Naf6fe43094234e89b120e81ff5e95a05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Enterovirus Infections
155 rdf:type schema:DefinedTerm
156 Nafb0e700b5d646558a67c176f3be4efa schema:name readcube_id
157 schema:value 6aae79f28078c214210d87041f294d7595d2534c1f864390da148aa1b23ef228
158 rdf:type schema:PropertyValue
159 Nba29d640748e406782ac7df4e9df3d5e schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Ncf353d4108cf40e5b1777ef1b9d52c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Interleukin-10
163 rdf:type schema:DefinedTerm
164 Nd0076f35d15241df8278a4178cd6c9ca rdf:first sg:person.01041062124.19
165 rdf:rest N90d156d506fe4b1e9189e1a0d0309823
166 Nd1d6e0713b8d41f49db9d115b3cb7d15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Child
168 rdf:type schema:DefinedTerm
169 Nd5716635fbba410e9d3bcf767ea483af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Infant
171 rdf:type schema:DefinedTerm
172 Nd87b9c5a87a24a62b05f2f69dd7c8777 rdf:first sg:person.01037525174.00
173 rdf:rest N202fcfc5103344909bfbecdd8155388a
174 Ndb446d089c1946bc9fcb4055dda0e0c1 schema:issueNumber 2
175 rdf:type schema:PublicationIssue
176 Nea9dff0073ff4094906cbf42c328042c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Female
178 rdf:type schema:DefinedTerm
179 Nf74a8fef230f42e49d8aa451313e3144 schema:name pubmed_id
180 schema:value 23605689
181 rdf:type schema:PropertyValue
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
186 schema:name Immunology
187 rdf:type schema:DefinedTerm
188 sg:journal.1027081 schema:issn 1591-8890
189 1591-9528
190 schema:name Clinical and Experimental Medicine
191 rdf:type schema:Periodical
192 sg:person.01037525174.00 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
193 schema:familyName Fu
194 schema:givenName Miao
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037525174.00
196 rdf:type schema:Person
197 sg:person.01041062124.19 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
198 schema:familyName Lin
199 schema:givenName Aifen
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041062124.19
201 rdf:type schema:Person
202 sg:person.01071035727.00 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
203 schema:familyName Zheng
204 schema:givenName Xiao-Qun
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071035727.00
206 rdf:type schema:Person
207 sg:person.01105640374.38 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
208 schema:familyName Gao
209 schema:givenName Yan
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105640374.38
211 rdf:type schema:Person
212 sg:person.01155310524.84 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
213 schema:familyName Xu
214 schema:givenName Dan-Ping
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155310524.84
216 rdf:type schema:Person
217 sg:person.01206356160.52 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
218 schema:familyName Yan
219 schema:givenName Wei-Hua
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206356160.52
221 rdf:type schema:Person
222 sg:pub.10.1007/s00018-010-0578-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020376198
223 https://doi.org/10.1007/s00018-010-0578-1
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s00018-010-0581-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022889918
226 https://doi.org/10.1007/s00018-010-0581-6
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nri2575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032277257
229 https://doi.org/10.1038/nri2575
230 rdf:type schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1077414321 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1077676819 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1078336841 schema:CreativeWork
234 https://doi.org/10.1016/j.coph.2009.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013430113
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.humimm.2006.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042658556
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.humimm.2008.08.280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001201428
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.humimm.2009.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037422444
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.humimm.2010.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029784148
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.humimm.2011.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046052780
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.humimm.2011.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007988493
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.it.2007.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045248164
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.micinf.2010.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040295131
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.micinf.2010.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051777524
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s0198-8859(00)00197-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041114505
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s1473-3099(10)70194-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004687004
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s1875-9572(08)60024-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037229789
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1086/345905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041834002
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1086/376998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012374878
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1086/591462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047299974
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1086/604733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058809823
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1093/infdis/129.3.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059695291
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1097/00002030-200202150-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029979978
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1097/inf.0b013e3181a41d63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045308163
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1097/qad.0b013e32832d0825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050887704
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1365-2893.2010.01286.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019192071
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.1469-0691.2007.01729.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010791963
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1600-0897.2009.00723.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012311656
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1651-2227.2002.tb03292.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002838168
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1128/jvi.01779-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031404743
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1128/jvi.79.24.15226-15237.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046656597
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1586/eri.09.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068079972
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2174/187153011794982059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069223422
291 rdf:type schema:CreativeWork
292 https://doi.org/10.4049/jimmunol.164.12.6426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074649937
293 rdf:type schema:CreativeWork
294 https://www.grid.ac/institutes/grid.268099.c schema:alternateName Wenzhou Medical College
295 schema:name Department of the Infectious Diseases, the YuYin Children Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
296 Department of the Laboratory Medicine, the Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
297 Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China
298 Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...