Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-03

AUTHORS

Kalil William Alves de Lima, Roberta Losi Guembarovski, Julie Massayo Maeda Oda, Gyl Ramos, Benedito Valdecir Oliveira, Iglenir João Cavalli, Enilze Maria de Souza Fonseca Ribeiro, Marlene Silva Bardi Gonçalves, Mateus Nobrega Aoki, Sandra Odebrecht Vargas Nunes, Maria Angelica Ehara Watanabe

ABSTRACT

The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83-60.91 and OR = 24.73; IC 95% = 3.17-192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24-1.33 and OR = 0.46; 95% CI = 0.20-1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence. More... »

PAGES

13-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10238-011-0140-y

DOI

http://dx.doi.org/10.1007/s10238-011-0140-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011965752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21626393


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