Ontology type: schema:ScholarlyArticle
2008-06
AUTHORST. Arai, H. Hashimoto, K. Kawai, A. Mori, Y. Ohnishi, K. Hioki, M. Ito, M. Saito, Y. Ueyama, M. Ohsugi, R. Suzuki, N. Kubota, T. Yamauchi, K. Tobe, T. Kadowaki, K. Kosaka
ABSTRACTThe objective of this study was to characterise the fulminant type 1 diabetes mellitus (DM) accompanying abrupt hyperglycaemia and ketonuria observed in insulin receptor substrate 2 (IRS2)-deficient mice. IRS2-deficient mice backcrossed onto the original C57BL/6J:Jc1 background (B6J-IRS2−/− mice) for more than 10 generations were used. Eight male IRS2-deficient mice with ketonuria and abrupt increase in plasma glucose concentrations over 25 mmol/l were used as the fulminant type 1 diabetic mice (diabetic mice) and 8 male IRS2-deficient mice (8 weeks old) without glycosuria were used as the control mice. Plasma metabolite, immunoreactive insulin (IRI) and C-peptide concentrations, hepatic energy metabolism related enzyme activities and histopathological change in pancreatic islets were investigated. The diabetic mice showed significantly higher plasma glucose and cholesterol concentrations and lower plasma IRI and C-peptide concentrations than the control mice. In livers of the diabetic mice, glycolytic and malate-aspartate shuttle enzyme activities decreased significantly and gluconeogenic, lipogenic and ketone body synthesis enzyme activities increased significantly compared to those in the control mice. The pancreatic islets of the diabetic mice decreased significantly in size and number of β cells. The diabetic IRS2-deficient mice did not show the islet-related antibodies observed in the diabetic NOD mice in their sera. The characteristics of the diabetic IRS2-deficient mice resembled those of the human nonautoimmune fulminant type 1 DM. IRS2-deficient mice may be a useful animal model for studying the degradation mechanism of pancreatic β cells in the process of development of fulminant type 1 DM. More... »
PAGES93-99
http://scigraph.springernature.com/pub.10.1007/s10238-008-0163-1
DOIhttp://dx.doi.org/10.1007/s10238-008-0163-1
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1018169586
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18618219
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diabetes Mellitus, Type 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fatty Acids, Nonesterified",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin Receptor Substrate Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intracellular Signaling Peptides and Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred NOD",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Triglycerides",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, 180-8602, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.412202.7",
"name": [
"Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, 180-8602, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Arai",
"givenName": "T.",
"id": "sg:person.0750657730.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750657730.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.452212.2",
"name": [
"Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Hashimoto",
"givenName": "H.",
"id": "sg:person.0612617362.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612617362.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.452212.2",
"name": [
"Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Kawai",
"givenName": "K.",
"id": "sg:person.0575370733.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575370733.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Japan",
"id": "http://www.grid.ac/institutes/grid.412202.7",
"name": [
"Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Japan"
],
"type": "Organization"
},
"familyName": "Mori",
"givenName": "A.",
"id": "sg:person.0721422602.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721422602.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.452212.2",
"name": [
"Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Ohnishi",
"givenName": "Y.",
"id": "sg:person.0751522134.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751522134.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.452212.2",
"name": [
"Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Hioki",
"givenName": "K.",
"id": "sg:person.01341440063.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341440063.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.452212.2",
"name": [
"Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Ito",
"givenName": "M.",
"id": "sg:person.015367606562.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015367606562.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.452212.2",
"name": [
"Animal Resource Center, Central Institute for Experimental Animals, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Saito",
"givenName": "M.",
"id": "sg:person.015541543365.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015541543365.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Ueyama",
"givenName": "Y.",
"id": "sg:person.01135276626.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135276626.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Ohsugi",
"givenName": "M.",
"id": "sg:person.0576536747.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576536747.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Suzuki",
"givenName": "R.",
"id": "sg:person.01170707724.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170707724.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kubota",
"givenName": "N.",
"id": "sg:person.0706615603.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706615603.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yamauchi",
"givenName": "T.",
"id": "sg:person.012027672272.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012027672272.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Tobe",
"givenName": "K.",
"id": "sg:person.01100423277.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100423277.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kadowaki",
"givenName": "T.",
"id": "sg:person.01353472360.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353472360.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kosaka",
"givenName": "K.",
"id": "sg:person.076537560.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.076537560.46"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/372182a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046415369",
"https://doi.org/10.1038/372182a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11259-005-3223-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045346050",
"https://doi.org/10.1007/s11259-005-3223-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-004-1626-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013271852",
"https://doi.org/10.1007/s00125-004-1626-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/372186a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049271444",
"https://doi.org/10.1038/372186a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-005-1829-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017463483",
"https://doi.org/10.1007/s00125-005-1829-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/12631",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011418048",
"https://doi.org/10.1038/12631"
],
"type": "CreativeWork"
}
],
"datePublished": "2008-06",
"datePublishedReg": "2008-06-01",
"description": "The objective of this study was to characterise the fulminant type 1 diabetes mellitus (DM) accompanying abrupt hyperglycaemia and ketonuria observed in insulin receptor substrate 2 (IRS2)-deficient mice. IRS2-deficient mice backcrossed onto the original C57BL/6J:Jc1 background (B6J-IRS2\u2212/\u2212 mice) for more than 10 generations were used. Eight male IRS2-deficient mice with ketonuria and abrupt increase in plasma glucose concentrations over 25 mmol/l were used as the fulminant type 1 diabetic mice (diabetic mice) and 8 male IRS2-deficient mice (8 weeks old) without glycosuria were used as the control mice. Plasma metabolite, immunoreactive insulin (IRI) and C-peptide concentrations, hepatic energy metabolism related enzyme activities and histopathological change in pancreatic islets were investigated. The diabetic mice showed significantly higher plasma glucose and cholesterol concentrations and lower plasma IRI and C-peptide concentrations than the control mice. In livers of the diabetic mice, glycolytic and malate-aspartate shuttle enzyme activities decreased significantly and gluconeogenic, lipogenic and ketone body synthesis enzyme activities increased significantly compared to those in the control mice. The pancreatic islets of the diabetic mice decreased significantly in size and number of \u03b2 cells. The diabetic IRS2-deficient mice did not show the islet-related antibodies observed in the diabetic NOD mice in their sera. The characteristics of the diabetic IRS2-deficient mice resembled those of the human nonautoimmune fulminant type 1 DM. IRS2-deficient mice may be a useful animal model for studying the degradation mechanism of pancreatic \u03b2 cells in the process of development of fulminant type 1 DM.",
"genre": "article",
"id": "sg:pub.10.1007/s10238-008-0163-1",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1027081",
"issn": [
"1591-8890",
"1591-9528"
],
"name": "Clinical and Experimental Medicine",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"keywords": [
"fulminant type 1 diabetes mellitus",
"type 1 diabetes mellitus",
"Irs2-deficient mice",
"C-peptide concentrations",
"diabetes mellitus",
"diabetic mice",
"control mice",
"immunoreactive insulin",
"deficient mice",
"pancreatic islets",
"type 1 diabetic mice",
"\u03b2-cells",
"Insulin receptor substrate-2-deficient (IRS2(-/-)) mice",
"diabetic NOD mice",
"plasma immunoreactive insulin",
"plasma glucose concentration",
"higher plasma glucose",
"useful animal model",
"insulin receptor substrate 2",
"hepatic energy metabolism",
"pancreatic \u03b2-cells",
"NOD mice",
"histopathological changes",
"plasma glucose",
"cholesterol concentrations",
"animal models",
"plasma metabolites",
"mice",
"enzyme activity",
"mellitus",
"glucose concentration",
"ketonuria",
"energy metabolism",
"islets",
"substrate 2",
"hyperglycaemia",
"glycosuria",
"cells",
"insulin",
"liver",
"activity",
"serum",
"C57BL/6J",
"antibodies",
"concentration",
"metabolism",
"glucose",
"metabolites",
"study",
"background",
"increase",
"abrupt increase",
"objective",
"changes",
"mechanism",
"development",
"number",
"process of development",
"characteristics",
"size",
"model",
"generation",
"process",
"degradation mechanism"
],
"name": "Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice",
"pagination": "93-99",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1018169586"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10238-008-0163-1"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"18618219"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10238-008-0163-1",
"https://app.dimensions.ai/details/publication/pub.1018169586"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_471.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s10238-008-0163-1"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10238-008-0163-1'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10238-008-0163-1'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10238-008-0163-1'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10238-008-0163-1'
This table displays all metadata directly associated to this object as RDF triples.
310 TRIPLES
22 PREDICATES
108 URIs
94 LITERALS
18 BLANK NODES