Decreased antigen-specific T-cell proliferation by moDC among hepatitis B vaccine non-responders on haemodialysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-06

AUTHORS

M. A. Verkade, C. J. van Druningen, C. T. op de Hoek, W. Weimar, M. G. H. Betjes

ABSTRACT

Patients with end-stage kidney disease, whether or not on renal replacement therapy, have an impaired immune system. This is clinically manifested by a large percentage of patients unresponsive to the standard vaccination procedure for hepatitis B virus (HBV). In this study, the immune response to HBV vaccination is related to the in vitro function of monocyte-derived dendritic cells (moDC). We demonstrate that mature moDC from nonresponders to HBV vaccination have a less mature phenotype, compared to responders and healthy volunteers, although this did not affect their allostimulatory capacity. However, proliferation of autologous T cells in the presence of tetanus toxoid and candida antigen was decreased in non-responders. Also, HLA-matched CD4+ hsp65-specific human T-cell clones showed markedly decreased proliferation in the group of non-responders. Our results indicate that impairment of moDC to stimulate antigen-specific T cells provides an explanation for the clinical immunodeficiency of patients with end-stage kidney disease. More... »

PAGES

65-71

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10238-007-0127-x

DOI

http://dx.doi.org/10.1007/s10238-007-0127-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001794827

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17609878


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