Clinical features of patients with anti-neutrophil cytoplasmic autoantibodies targeting native myeloperoxidase antigen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-09

AUTHORS

Yuji Yamanishi, Toshiko Ito-Ihara, Tomokazu Nagao, Kazuko Uno, Shigeto Kobayashi, Eri Muso, Peter Y. Shane, Gary S. Firestein, Hiroshi Hashimoto, Tomio Okazaki, Kazuo Suzuki

ABSTRACT

OBJECTIVES: Anti-neutrophil cytoplasmic autoantibodies (ANCA) are useful diagnostic markers in systemic vasculitic disorders with small-vessel involvement, but depending on the particular test used, the myeloperoxidase (MPO)-ANCA results are variable. In the present study, we performed a comparative analysis between our originally developed nMPO-ANCA assay that targets the native MPO antigen and other commercially available assays using sera of patients with clinical features of ANCA-associated vasculitis (AAV). METHODS: Sera of 24 patients strongly suspected of having AAV were examined for the presence of MPO-ANCAs by our nMPO-ANCA assay and by other commercial-based MPO-ANCA assays. These results were correlated to indirect immunofluorescence microscopy staining patterns and patient clinical parameters. RESULTS: Eighteen out of 24 patients (75 %) were positive for nMPO-ANCA, compared with 13 out of 24 patients (54 %) by one of the most frequently used commercial-based MPO-ANCA enzyme-linked immunosorbent assays (ELISAs) in Japan. Interestingly, the patients who tested positive with our nMPO-ANCA assay alone showed clinical features of AAV marked by continuous fever, polyarthritis, and mild nephritis. The titers of nMPO-ANCA decreased in association with clinical improvement after treatment. CONCLUSIONS: Our data suggest that a positive nMPO-ANCA result, which identifies antibodies to human native MPO antigen, correlates with AAV disease activity. Moreover, the nMPO-ANCA test has clinical utility in detecting AAV-affected patients who have tested negative using commercially available assays. More... »

PAGES

963-971

References to SciGraph publications

  • 1990-08. Wegener's autoantigen decoded in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10165-012-0781-z

    DOI

    http://dx.doi.org/10.1007/s10165-012-0781-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000083359

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23085883


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