Ultrasonography is a potent tool for the prediction of progressive joint destruction during clinical remission of rheumatoid arthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-07-18

AUTHORS

Ryusuke Yoshimi, Maasa Hama, Kaoru Takase, Atsushi Ihata, Daiga Kishimoto, Kayo Terauchi, Reikou Watanabe, Takeaki Uehara, Sei Samukawa, Atsuhisa Ueda, Mitsuhiro Takeno, Yoshiaki Ishigatsubo

ABSTRACT

ObjectivesAlthough “clinical remission” has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can predict progressive joint destruction during clinical remission of RA.MethodsThirty-one patients with RA in clinical remission based on the disease activity score in 28 joints were recruited for this study. Bilateral wrists and all of the metacarpophalangeal and proximal interphalangeal (PIP) joints were examined by power Doppler (PD) ultrasonography (US), and the PD signals were scored semiquantitatively in each joint. The total PD score was calculated as the sum of individual scores for each joint.ResultsAmong 22 RA patients who maintained clinical remission during the 2-year follow-up period, seven showed radiographic progression. Radiographic progression was strongly associated with total PD score at entry, with all patients showing radiographic progression having a total PD score of ≥2 at entry and none of the patients with a total PD score of ≤1 showing any radiographic progression. There was no significant association of therapeutic agents with progressing or non-progressing cases.ConclusionsPD-US detects synovitis causing joint destruction even when the patient is in clinical remission. Thus, remission visible on US is essential to reach “true remission” of RA. More... »

PAGES

456-465

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10165-012-0690-1

DOI

http://dx.doi.org/10.1007/s10165-012-0690-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036215587

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22802010


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antirheumatic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthritis, Rheumatoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Joints", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synovitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography, Doppler", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshimi", 
        "givenName": "Ryusuke", 
        "id": "sg:person.01207257733.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207257733.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hama", 
        "givenName": "Maasa", 
        "id": "sg:person.01203416633.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203416633.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takase", 
        "givenName": "Kaoru", 
        "id": "sg:person.0756602733.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756602733.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ihata", 
        "givenName": "Atsushi", 
        "id": "sg:person.01364010267.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364010267.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kishimoto", 
        "givenName": "Daiga", 
        "id": "sg:person.01053764557.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053764557.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terauchi", 
        "givenName": "Kayo", 
        "id": "sg:person.011622074633.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011622074633.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Reikou", 
        "id": "sg:person.0607374601.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607374601.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uehara", 
        "givenName": "Takeaki", 
        "id": "sg:person.01077164063.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077164063.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samukawa", 
        "givenName": "Sei", 
        "id": "sg:person.01104153361.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104153361.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Atsuhisa", 
        "id": "sg:person.01032032373.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032032373.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeno", 
        "givenName": "Mitsuhiro", 
        "id": "sg:person.01027461256.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027461256.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishigatsubo", 
        "givenName": "Yoshiaki", 
        "id": "sg:person.01125133646.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125133646.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00256-010-1064-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026797282", 
          "https://doi.org/10.1007/s00256-010-1064-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-010-0293-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000337192", 
          "https://doi.org/10.1007/s10165-010-0293-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar3341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019283741", 
          "https://doi.org/10.1186/ar3341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-009-0190-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013181451", 
          "https://doi.org/10.1007/s10165-009-0190-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-011-1802-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028634147", 
          "https://doi.org/10.1007/s00296-011-1802-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-010-0367-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001253751", 
          "https://doi.org/10.1007/s10165-010-0367-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-010-0318-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027279913", 
          "https://doi.org/10.1007/s10165-010-0318-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-011-0512-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005458025", 
          "https://doi.org/10.1007/s10165-011-0512-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-07-18", 
    "datePublishedReg": "2012-07-18", 
    "description": "ObjectivesAlthough \u201cclinical remission\u201d has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can predict progressive joint destruction during clinical remission of RA.MethodsThirty-one patients with RA in clinical remission based on the disease activity score in 28 joints were recruited for this study. Bilateral wrists and all of the metacarpophalangeal and proximal interphalangeal (PIP) joints were examined by power Doppler (PD) ultrasonography (US), and the PD signals were scored semiquantitatively in each joint. The total PD score was calculated as the sum of individual scores for each joint.ResultsAmong 22 RA patients who maintained clinical remission during the 2-year follow-up period, seven showed radiographic progression. Radiographic progression was strongly associated with total PD score at entry, with all patients showing radiographic progression having a total PD score of \u22652 at entry and none of the patients with a total PD score of \u22641 showing any radiographic progression. There was no significant association of therapeutic agents with progressing or non-progressing cases.ConclusionsPD-US detects synovitis causing joint destruction even when the patient is in clinical remission. Thus, remission visible on US is essential to reach \u201ctrue remission\u201d of RA.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10165-012-0690-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6071961", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023369", 
        "issn": [
          "1439-7595", 
          "1439-7609"
        ], 
        "name": "Modern Rheumatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "total PD score", 
      "clinical remission", 
      "progressive joint destruction", 
      "rheumatoid arthritis", 
      "radiographic progression", 
      "joint destruction", 
      "PD scores", 
      "non-progressing cases", 
      "Disease Activity Score", 
      "proximal interphalangeal joints", 
      "power Doppler ultrasonography", 
      "subclinical synovitis", 
      "bilateral wrist", 
      "true remission", 
      "RA patients", 
      "activity score", 
      "Doppler ultrasonography", 
      "remission", 
      "interphalangeal joint", 
      "patients", 
      "ultrasonography", 
      "significant association", 
      "therapeutic agents", 
      "progression", 
      "arthritis", 
      "synovitis", 
      "scores", 
      "realistic goal", 
      "individual scores", 
      "joints", 
      "destruction", 
      "MethodsThirty", 
      "follow", 
      "metacarpophalangeal", 
      "wrist", 
      "structural damage", 
      "treatment", 
      "potent tool", 
      "study", 
      "association", 
      "entry", 
      "ObjectivesAlthough", 
      "agents", 
      "damage", 
      "evidence", 
      "period", 
      "cases", 
      "goal", 
      "tool", 
      "PD signals", 
      "signals", 
      "sum", 
      "prediction", 
      "ongoing structural damage", 
      "ResultsAmong 22 RA patients", 
      "ConclusionsPD-US detects synovitis", 
      "detects synovitis"
    ], 
    "name": "Ultrasonography is a potent tool for the prediction of progressive joint destruction during clinical remission of rheumatoid arthritis", 
    "pagination": "456-465", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036215587"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10165-012-0690-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22802010"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10165-012-0690-1", 
      "https://app.dimensions.ai/details/publication/pub.1036215587"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_564.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10165-012-0690-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10165-012-0690-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10165-012-0690-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10165-012-0690-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10165-012-0690-1'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      22 PREDICATES      105 URIs      89 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10165-012-0690-1 schema:about N05cb15a36e71417889a4248bc7819265
2 N080feaa1a1d7414e8517753da168ac61
3 N0db2c5c7eba1437ca5e7657cbb26723e
4 N12181fd342084e58b8372bb3d5fed337
5 N27af2b5ca3b64d2a842b88eb8999c48c
6 N35177f4af5f946349c49b5b7894583db
7 N54a89e28c2f94ec79a495a723aab637b
8 N62fff2569ed34b92b7cc110f384eeec0
9 N67dac795544e4f598a8f5a653e2a8943
10 N786125f35f2a463fa5f7a285343f016a
11 Nadc09f00ce144867a104e956729b9989
12 Ne518208f85d745eb81f78e9766e9e1ca
13 Nee5a33c6b6f04ee9be211a5b891e1aac
14 Nf8f3d92b14854282b72379c56e31eca8
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N165e94522d434d87b430b1e11528dfa3
18 schema:citation sg:pub.10.1007/s00256-010-1064-4
19 sg:pub.10.1007/s00296-011-1802-5
20 sg:pub.10.1007/s10165-009-0190-0
21 sg:pub.10.1007/s10165-010-0293-7
22 sg:pub.10.1007/s10165-010-0318-2
23 sg:pub.10.1007/s10165-010-0367-6
24 sg:pub.10.1007/s10165-011-0512-x
25 sg:pub.10.1186/ar3341
26 schema:datePublished 2012-07-18
27 schema:datePublishedReg 2012-07-18
28 schema:description ObjectivesAlthough “clinical remission” has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can predict progressive joint destruction during clinical remission of RA.MethodsThirty-one patients with RA in clinical remission based on the disease activity score in 28 joints were recruited for this study. Bilateral wrists and all of the metacarpophalangeal and proximal interphalangeal (PIP) joints were examined by power Doppler (PD) ultrasonography (US), and the PD signals were scored semiquantitatively in each joint. The total PD score was calculated as the sum of individual scores for each joint.ResultsAmong 22 RA patients who maintained clinical remission during the 2-year follow-up period, seven showed radiographic progression. Radiographic progression was strongly associated with total PD score at entry, with all patients showing radiographic progression having a total PD score of ≥2 at entry and none of the patients with a total PD score of ≤1 showing any radiographic progression. There was no significant association of therapeutic agents with progressing or non-progressing cases.ConclusionsPD-US detects synovitis causing joint destruction even when the patient is in clinical remission. Thus, remission visible on US is essential to reach “true remission” of RA.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree false
32 schema:isPartOf N061423a265b74fd0ba438b66031a3bfc
33 N489e97fef39749b884e622a571c2f08f
34 sg:journal.1023369
35 schema:keywords ConclusionsPD-US detects synovitis
36 Disease Activity Score
37 Doppler ultrasonography
38 MethodsThirty
39 ObjectivesAlthough
40 PD scores
41 PD signals
42 RA patients
43 ResultsAmong 22 RA patients
44 activity score
45 agents
46 arthritis
47 association
48 bilateral wrist
49 cases
50 clinical remission
51 damage
52 destruction
53 detects synovitis
54 entry
55 evidence
56 follow
57 goal
58 individual scores
59 interphalangeal joint
60 joint destruction
61 joints
62 metacarpophalangeal
63 non-progressing cases
64 ongoing structural damage
65 patients
66 period
67 potent tool
68 power Doppler ultrasonography
69 prediction
70 progression
71 progressive joint destruction
72 proximal interphalangeal joints
73 radiographic progression
74 realistic goal
75 remission
76 rheumatoid arthritis
77 scores
78 signals
79 significant association
80 structural damage
81 study
82 subclinical synovitis
83 sum
84 synovitis
85 therapeutic agents
86 tool
87 total PD score
88 treatment
89 true remission
90 ultrasonography
91 wrist
92 schema:name Ultrasonography is a potent tool for the prediction of progressive joint destruction during clinical remission of rheumatoid arthritis
93 schema:pagination 456-465
94 schema:productId N6e59172f41b04c579c2d0625e7cde363
95 Na9e5fa1d448c404a9979d3a13be12fed
96 Ndfa21199fda346cd99bec586a6c9acd9
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036215587
98 https://doi.org/10.1007/s10165-012-0690-1
99 schema:sdDatePublished 2021-12-01T19:27
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N68a9e79865ef4ae08afe2c70135a2b67
102 schema:url https://doi.org/10.1007/s10165-012-0690-1
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N05cb15a36e71417889a4248bc7819265 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Ultrasonography, Doppler
108 rdf:type schema:DefinedTerm
109 N061423a265b74fd0ba438b66031a3bfc schema:volumeNumber 23
110 rdf:type schema:PublicationVolume
111 N080feaa1a1d7414e8517753da168ac61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Arthritis, Rheumatoid
113 rdf:type schema:DefinedTerm
114 N0db2c5c7eba1437ca5e7657cbb26723e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Middle Aged
116 rdf:type schema:DefinedTerm
117 N12181fd342084e58b8372bb3d5fed337 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Male
119 rdf:type schema:DefinedTerm
120 N165e94522d434d87b430b1e11528dfa3 rdf:first sg:person.01207257733.06
121 rdf:rest N7399736317964356819d228ba85bc5c2
122 N27af2b5ca3b64d2a842b88eb8999c48c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Female
124 rdf:type schema:DefinedTerm
125 N339098d3cccc4000b9fcd44d513c4a7f rdf:first sg:person.01104153361.18
126 rdf:rest N81402f32d9a640838b6b173da6a4e5bb
127 N35177f4af5f946349c49b5b7894583db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Remission Induction
129 rdf:type schema:DefinedTerm
130 N489e97fef39749b884e622a571c2f08f schema:issueNumber 3
131 rdf:type schema:PublicationIssue
132 N54a89e28c2f94ec79a495a723aab637b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 N62fff2569ed34b92b7cc110f384eeec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Adult
137 rdf:type schema:DefinedTerm
138 N67dac795544e4f598a8f5a653e2a8943 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Joints
140 rdf:type schema:DefinedTerm
141 N68a9e79865ef4ae08afe2c70135a2b67 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N6e59172f41b04c579c2d0625e7cde363 schema:name pubmed_id
144 schema:value 22802010
145 rdf:type schema:PropertyValue
146 N71962fb559f940b5941112c5fbc4a675 rdf:first sg:person.01077164063.38
147 rdf:rest N339098d3cccc4000b9fcd44d513c4a7f
148 N7399736317964356819d228ba85bc5c2 rdf:first sg:person.01203416633.15
149 rdf:rest N9f5b70c680a34240bce23576625540fa
150 N786125f35f2a463fa5f7a285343f016a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Antirheumatic Agents
152 rdf:type schema:DefinedTerm
153 N79ca2747abcd4db3947ec3ca817b2bf1 rdf:first sg:person.011622074633.10
154 rdf:rest Ne62c57600cb44d759a7305f949b481cd
155 N7caa48f5480347ad99d3e92f1df86b65 rdf:first sg:person.01364010267.46
156 rdf:rest N7e5bc27ead5644d89866bd4eec051fcf
157 N7e5bc27ead5644d89866bd4eec051fcf rdf:first sg:person.01053764557.34
158 rdf:rest N79ca2747abcd4db3947ec3ca817b2bf1
159 N81402f32d9a640838b6b173da6a4e5bb rdf:first sg:person.01032032373.04
160 rdf:rest Nc8ce4641017748cb999a15fe7c49720b
161 N9f5b70c680a34240bce23576625540fa rdf:first sg:person.0756602733.05
162 rdf:rest N7caa48f5480347ad99d3e92f1df86b65
163 Na9e5fa1d448c404a9979d3a13be12fed schema:name doi
164 schema:value 10.1007/s10165-012-0690-1
165 rdf:type schema:PropertyValue
166 Nadc09f00ce144867a104e956729b9989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Disease Progression
168 rdf:type schema:DefinedTerm
169 Nb6e6f49c6e944e3c877802755338226e rdf:first sg:person.01125133646.44
170 rdf:rest rdf:nil
171 Nc8ce4641017748cb999a15fe7c49720b rdf:first sg:person.01027461256.90
172 rdf:rest Nb6e6f49c6e944e3c877802755338226e
173 Ndfa21199fda346cd99bec586a6c9acd9 schema:name dimensions_id
174 schema:value pub.1036215587
175 rdf:type schema:PropertyValue
176 Ne518208f85d745eb81f78e9766e9e1ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Aged
178 rdf:type schema:DefinedTerm
179 Ne62c57600cb44d759a7305f949b481cd rdf:first sg:person.0607374601.30
180 rdf:rest N71962fb559f940b5941112c5fbc4a675
181 Nee5a33c6b6f04ee9be211a5b891e1aac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Synovitis
183 rdf:type schema:DefinedTerm
184 Nf8f3d92b14854282b72379c56e31eca8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Longitudinal Studies
186 rdf:type schema:DefinedTerm
187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical and Health Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
191 schema:name Clinical Sciences
192 rdf:type schema:DefinedTerm
193 sg:grant.6071961 http://pending.schema.org/fundedItem sg:pub.10.1007/s10165-012-0690-1
194 rdf:type schema:MonetaryGrant
195 sg:journal.1023369 schema:issn 1439-7595
196 1439-7609
197 schema:name Modern Rheumatology
198 rdf:type schema:Periodical
199 sg:person.01027461256.90 schema:affiliation grid-institutes:grid.268441.d
200 schema:familyName Takeno
201 schema:givenName Mitsuhiro
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027461256.90
203 rdf:type schema:Person
204 sg:person.01032032373.04 schema:affiliation grid-institutes:grid.268441.d
205 schema:familyName Ueda
206 schema:givenName Atsuhisa
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032032373.04
208 rdf:type schema:Person
209 sg:person.01053764557.34 schema:affiliation grid-institutes:grid.268441.d
210 schema:familyName Kishimoto
211 schema:givenName Daiga
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053764557.34
213 rdf:type schema:Person
214 sg:person.01077164063.38 schema:affiliation grid-institutes:grid.268441.d
215 schema:familyName Uehara
216 schema:givenName Takeaki
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077164063.38
218 rdf:type schema:Person
219 sg:person.01104153361.18 schema:affiliation grid-institutes:grid.268441.d
220 schema:familyName Samukawa
221 schema:givenName Sei
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104153361.18
223 rdf:type schema:Person
224 sg:person.01125133646.44 schema:affiliation grid-institutes:grid.268441.d
225 schema:familyName Ishigatsubo
226 schema:givenName Yoshiaki
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125133646.44
228 rdf:type schema:Person
229 sg:person.011622074633.10 schema:affiliation grid-institutes:grid.268441.d
230 schema:familyName Terauchi
231 schema:givenName Kayo
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011622074633.10
233 rdf:type schema:Person
234 sg:person.01203416633.15 schema:affiliation grid-institutes:grid.268441.d
235 schema:familyName Hama
236 schema:givenName Maasa
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203416633.15
238 rdf:type schema:Person
239 sg:person.01207257733.06 schema:affiliation grid-institutes:grid.268441.d
240 schema:familyName Yoshimi
241 schema:givenName Ryusuke
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207257733.06
243 rdf:type schema:Person
244 sg:person.01364010267.46 schema:affiliation grid-institutes:grid.268441.d
245 schema:familyName Ihata
246 schema:givenName Atsushi
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364010267.46
248 rdf:type schema:Person
249 sg:person.0607374601.30 schema:affiliation grid-institutes:grid.268441.d
250 schema:familyName Watanabe
251 schema:givenName Reikou
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607374601.30
253 rdf:type schema:Person
254 sg:person.0756602733.05 schema:affiliation grid-institutes:grid.268441.d
255 schema:familyName Takase
256 schema:givenName Kaoru
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756602733.05
258 rdf:type schema:Person
259 sg:pub.10.1007/s00256-010-1064-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026797282
260 https://doi.org/10.1007/s00256-010-1064-4
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s00296-011-1802-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028634147
263 https://doi.org/10.1007/s00296-011-1802-5
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s10165-009-0190-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013181451
266 https://doi.org/10.1007/s10165-009-0190-0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s10165-010-0293-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000337192
269 https://doi.org/10.1007/s10165-010-0293-7
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s10165-010-0318-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027279913
272 https://doi.org/10.1007/s10165-010-0318-2
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s10165-010-0367-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001253751
275 https://doi.org/10.1007/s10165-010-0367-6
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/s10165-011-0512-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005458025
278 https://doi.org/10.1007/s10165-011-0512-x
279 rdf:type schema:CreativeWork
280 sg:pub.10.1186/ar3341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019283741
281 https://doi.org/10.1186/ar3341
282 rdf:type schema:CreativeWork
283 grid-institutes:grid.268441.d schema:alternateName Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan
284 schema:name Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, 236-0004, Kanazawa-ku, Yokohama, Japan
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...