Accumulation of mature B cells in the inflamed muscle tissue of a patient with anti-155/140 antibody-positive juvenile dermatomyositis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01

AUTHORS

Tadafumi Yokoyama, Masaki Shimizu, Sayaka Ishikawa, Kazuyuki Ueno, Yasuhito Hamaguchi, Kazuhiko Takehara, Akihiro Yachie

ABSTRACT

We report the first case of a Japanese patient with anti-155/140 antibody-positive juvenile dermatomyositis (JDM). Her clinical features included severe cutaneous involvement. Serum B cell-activating factor levels were significantly increased. Mature class-switched memory B cells accumulated in inflamed muscle tissue but decreased in peripheral blood. These findings indicate that loss of B cell tolerance and accumulation of mature B cells in inflamed muscle tissue play an important role in the pathogenesis of JDM. More... »

PAGES

167-171

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10165-012-0627-8

DOI

http://dx.doi.org/10.1007/s10165-012-0627-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034403117

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22454192


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