Therapeutic response of patients with adult Still’s disease to biologic agents: multicenter results in Japan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12-09

AUTHORS

Rie Suematsu, Akihide Ohta, Emi Matsuura, Hiroki Takahashi, Takao Fujii, Takahiko Horiuchi, Seiji Minota, Yoshiaki Ishigatsubo, Toshiyuki Ota, Shuji Takei, Sachiko Soejima, Hisako Inoue, Syuichi Koarada, Yoshifumi Tada, Kohei Nagasawa

ABSTRACT

ObjectiveThe efficacy of biologics in treating adult Still’s disease (ASD) is suggested, but the information is still lacking and the validation is insufficient. To determine the efficacy of several biologic agents in refractory ASD in Japan, a multicenter survey was performed.MethodClinical data on 16 ASD patients who had been treated with at least 1 of the biological agents (total 24 occasions) were collected retrospectively.ResultsInfliximab was used in 9 cases, etanercept in 4, and tocilizumab in 11. Half of the patients that had been treated initially with infliximab or etanercept were changed to another biologics. Tocilizumab was effective in cases switched from another 2 drugs. Tocilizumab showed efficacy in treating both systemic and arthritic symptoms and showed apparent steroid-sparing effect and the highest continuation rate.ConclusionTocilizumab may be a promising biologic agent in refractory ASD. More... »

PAGES

712-719

Journal

TITLE

Modern Rheumatology

ISSUE

5

VOLUME

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10165-011-0569-6

DOI

http://dx.doi.org/10.1007/s10165-011-0569-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037475550

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22160845


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35 schema:description ObjectiveThe efficacy of biologics in treating adult Still’s disease (ASD) is suggested, but the information is still lacking and the validation is insufficient. To determine the efficacy of several biologic agents in refractory ASD in Japan, a multicenter survey was performed.MethodClinical data on 16 ASD patients who had been treated with at least 1 of the biological agents (total 24 occasions) were collected retrospectively.ResultsInfliximab was used in 9 cases, etanercept in 4, and tocilizumab in 11. Half of the patients that had been treated initially with infliximab or etanercept were changed to another biologics. Tocilizumab was effective in cases switched from another 2 drugs. Tocilizumab showed efficacy in treating both systemic and arthritic symptoms and showed apparent steroid-sparing effect and the highest continuation rate.ConclusionTocilizumab may be a promising biologic agent in refractory ASD.
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42 schema:keywords ASD
43 ASD patients
44 ConclusionTocilizumab
45 Japan
46 MethodClinical data
47 ResultsInfliximab
48 adults
49 agents
50 apparent steroid-sparing effect
51 arthritic symptoms
52 biologic agents
53 biological agents
54 biologics
55 cases
56 continuation rates
57 data
58 disease
59 drugs
60 effect
61 efficacy
62 efficacy of biologics
63 etanercept
64 half
65 high continuation rates
66 infliximab
67 information
68 multicenter results
69 multicenter survey
70 patients
71 promising biologic agent
72 rate
73 refractory ASD
74 response
75 results
76 steroid-sparing effect
77 survey
78 symptoms
79 therapeutic response
80 tocilizumab
81 validation
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