Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with rheumatoid arthritis treated with methotrexate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09-08

AUTHORS

Keisuke Watanabe, Kaoru Takase, Shigeru Ohno, Haruko Ideguchi, Akito Nozaki, Yoshiaki Ishigatsubo

ABSTRACT

Immunosuppressive therapy can induce viral reactivation in patients with chronic hepatitis B virus (HBV) infection and, more rarely, in patients with resolved HBV infection. We report the case of a 57-year-old Japanese woman with rheumatoid arthritis (RA) who developed de-novo hepatitis B virus-related hepatitis after methotrexate (MTX) therapy. Entecavir and oral prednisolone following steroid pulse therapy were administered and her liver function recovered. MTX is widely used for RA for its efficiency and safety. But some cases of HBV reactivation caused by MTX, including de-novo hepatitis, have been reported. Considering these conditions, more attention should be paid when using MTX in patients with RA. And more studies are needed to determine who needs screening of HBV, monitoring of HBV-DNA, and prophylaxis with chemotherapy or immunosuppressive therapy. More... »

PAGES

470-473

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10165-011-0521-9

DOI

http://dx.doi.org/10.1007/s10165-011-0521-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000940515

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21901356


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