Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10

AUTHORS

Yohei Ichimura, Yoshihide Asano, Masaru Hatano, Zenshiro Tamaki, Tomonori Takekoshi, Asako Kogure, Manabu Tomita, Tomohiko Kawashima, Miki Miyazaki, Takashi Taniguchi, Takehiro Takahashi, Hiroshi Mitsui, Makoto Sugaya, Atsushi Yao, Koichiro Kinugawa, Shinichi Sato

ABSTRACT

Systemic sclerosis (SSc) is characterized by vascular injuries, and bosentan has recently been proved to be efficacious for the prevention of new digital ulcers in SSc. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc. More... »

PAGES

548-552

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10165-011-0436-5

DOI

http://dx.doi.org/10.1007/s10165-011-0436-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008327945

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21547701


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