Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-03-28

AUTHORS

Atsushi Komatsuda, Hideki Wakui, Takashi Nimura, Ken-ichi Sawada

ABSTRACT

A 63-year-old woman with active rheumatoid arthritis (RA) had been treated with methotrexate and prednisolone. She developed cervical lymph node swelling 30 months after the initiation of infliximab therapy. A computed tomography revealed cervical and mediastinal lymph node swelling and multiple nodules (up to 13 mm in diameter) in the lungs. A lymph node biopsy showed infiltration of numerous Hodgkin-like and Reed-Sternberg-like cells. Immunohistological studies showed that these cells were positive for CD15, CD30, and Epstein-Barr virus (EBV) latent membrane protein. In site hybridization revealed the presence of EBV RNA in the nuclei of these cells. EBV DNA was detected in the biopsy specimen by southern blot analysis. She was diagnosed as having EBV-associated lymphoproliferative disorder (LPD). Immunodeficiency-associated LPD related with infliximab therapy was considered. Cessation of infliximab therapy only led to dramatic regression of LPD. This case illustrates that EBV-associated LPDs can occur as part of infliximab adverse effects in patients with RA. More... »

PAGES

315-318

References to SciGraph publications

  • 2005-05-01. Infliximab-Associated Lymphoproliferative Disorders in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10165-008-0053-0

    DOI

    http://dx.doi.org/10.1007/s10165-008-0053-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010426230

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18368468


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