Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Yoojin Chung, Brian D. Buechel, Woongsang Sunwoo, Joseph D. Wagner, Bertrand Delgutte

ABSTRACT

Users of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Here, we characterized temporal coding and ITD sensitivity of single neurons in a novel animal model of early-onset deafness. Rabbits were deafened as neonates and deprived of auditory stimulation until they reached adult age when single-unit recordings from the auditory midbrain were made chronically using an unanesthetized preparation. The results are compared to measurements from adult-deafened rabbits with normal auditory development to understand the effect of early-onset deafness on neural temporal coding and ITD sensitivity. Neurons in the inferior colliculus (IC) of early-deafened rabbits were less likely to show sustained, excitatory responses to pulse train stimulation and more likely to show suppressive responses compared to neurons in adult-deaf animals. Fewer neurons showed synchronized responses to pulse trains at any rate in the early-deaf group. In addition, fewer neurons showed significant ITD sensitivity in their overall firing rate in the early-deaf group compared to adult-deaf animals. Neural ITD discrimination thresholds in the early-deaf group were poorer than thresholds in adult-deaf group, especially at high pulse rates. The overall degradation in neural ITD sensitivity is consistent with the difficulties encountered by human CI users with early-onset hearing loss. These results lay the groundwork for investigating whether the degradations in temporal coding and ITD sensitivity observed in early-deaf animals can be reversed by appropriate CI stimulation during development. More... »

PAGES

37-56

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10162-018-00708-w

DOI

http://dx.doi.org/10.1007/s10162-018-00708-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111258713

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30623319


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA", 
            "Department of Otolaryngology, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Yoojin", 
        "id": "sg:person.01232533151.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232533151.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA", 
            "Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buechel", 
        "givenName": "Brian D.", 
        "id": "sg:person.01024267353.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024267353.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gachon University Gil Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411653.4", 
          "name": [
            "Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA", 
            "Department of Otolaryngology, Harvard Medical School, 02115, Boston, MA, USA", 
            "Department of Otolaryngology, Gachon University Gil Medical Center, 405-760, Incheon, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sunwoo", 
        "givenName": "Woongsang", 
        "id": "sg:person.01341423720.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341423720.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Eye and Ear Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.39479.30", 
          "name": [
            "Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagner", 
        "givenName": "Joseph D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA", 
            "Department of Otolaryngology, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delgutte", 
        "givenName": "Bertrand", 
        "id": "sg:person.01035744777.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035744777.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cne.20888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003717556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.20888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003717556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.23038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003780199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnins.2016.00077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006058756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2006.04982.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007461381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0762-04.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008026407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-5955(98)00209-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008806838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2011.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009400046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00731.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009455654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(91)90120-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009715707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(91)90120-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009715707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.21886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010522106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/417543a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010760754", 
          "https://doi.org/10.1038/417543a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-016-0569-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015296753", 
          "https://doi.org/10.1007/s10162-016-0569-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-016-0569-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015296753", 
          "https://doi.org/10.1007/s10162-016-0569-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2015.12.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016157790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-5955(02)00644-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016409138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2011.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017539243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0048739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018844305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-5955(99)00171-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019715836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-015-0527-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021016552", 
          "https://doi.org/10.1007/s10162-015-0527-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-015-0527-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021016552", 
          "https://doi.org/10.1007/s10162-015-0527-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2084-13.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021409973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.22262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021834445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.22262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021834445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2008.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023877984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(02)02235-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025931228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-013-0380-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027342908", 
          "https://doi.org/10.1007/s10162-013-0380-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0052-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028057487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/h0035203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028457988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9861(19991004)412:4<543::aid-cne1>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029039678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-5955(97)00046-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029876209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fnl.09.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030432785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(74)90521-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030559232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(74)90521-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030559232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00269.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031364373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(69)90010-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034313821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3213-10.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037008023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhp222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037969329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2014.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038063487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2014.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038782763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00221-003-1619-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040067770", 
          "https://doi.org/10.1007/s00221-003-1619-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aud.0b013e31806dc21a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040782176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aud.0b013e31806dc21a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040782176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00900.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041627503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.1092310411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043010531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.1092310411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043010531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5517-09.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043484981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5517-09.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043484981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2008.01.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043587052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2004.067421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044488886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(92)90172-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044963902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(92)90172-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044963902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-0102(94)90043-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045551896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-0102(94)90043-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045551896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2010.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046909772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.22339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048360709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.22339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048360709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00303.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049167581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(90)90030-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053618165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(90)90030-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053618165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1121/1.3068457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062320903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1121/1.3257546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062322747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1121/1.395554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062346846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1121/1.396664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062347956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1121/1.405554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062356843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1119419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062452714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00392.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063199748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1699-16.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067642958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3795-15.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067643241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1999.82.3.1363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074519570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1999.82.6.2883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074564069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.20-04-01605.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074586884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.23-02-00716.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075219790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1989.61.2.269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079453828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1987.57.5.1338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079835763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1995.73.2.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082496255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.21452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084484845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2018.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101044346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2018.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101044346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2018.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101044346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3328-17.2018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105227964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-018-00693-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106809798", 
          "https://doi.org/10.1007/s10162-018-00693-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Users of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Here, we characterized temporal coding and ITD sensitivity of single neurons in a novel animal model of early-onset deafness. Rabbits were deafened as neonates and deprived of auditory stimulation until they reached adult age when single-unit recordings from the auditory midbrain were made chronically using an unanesthetized preparation. The results are compared to measurements from adult-deafened rabbits with normal auditory development to understand the effect of early-onset deafness on neural temporal coding and ITD sensitivity. Neurons in the inferior colliculus (IC) of early-deafened rabbits were less likely to show sustained, excitatory responses to pulse train stimulation and more likely to show suppressive responses compared to neurons in adult-deaf animals. Fewer neurons showed synchronized responses to pulse trains at any rate in the early-deaf group. In addition, fewer neurons showed significant ITD sensitivity in their overall firing rate in the early-deaf group compared to adult-deaf animals. Neural ITD discrimination thresholds in the early-deaf group were poorer than thresholds in adult-deaf group, especially at high pulse rates. The overall degradation in neural ITD sensitivity is consistent with the difficulties encountered by human CI users with early-onset hearing loss. These results lay the groundwork for investigating whether the degradations in temporal coding and ITD sensitivity observed in early-deaf animals can be reversed by appropriate CI stimulation during development.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10162-018-00708-w", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2682961", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4241821", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438937", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2488660", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021546", 
        "issn": [
          "1525-3961", 
          "1438-7573"
        ], 
        "name": "Journal of the Association for Research in Otolaryngology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness", 
    "pagination": "37-56", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2defb248a8a1e31494979bc4df40878b276c6cec7ffca00673be582fd5799723"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30623319"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100892857"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10162-018-00708-w"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111258713"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10162-018-00708-w", 
      "https://app.dimensions.ai/details/publication/pub.1111258713"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113644_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10162-018-00708-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10162-018-00708-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10162-018-00708-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10162-018-00708-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10162-018-00708-w'


 

This table displays all metadata directly associated to this object as RDF triples.

324 TRIPLES      21 PREDICATES      97 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10162-018-00708-w schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Naa8cbacf310743e0b6e118229d64f99f
4 schema:citation sg:pub.10.1007/s00221-003-1619-x
5 sg:pub.10.1007/s10162-013-0380-5
6 sg:pub.10.1007/s10162-015-0527-7
7 sg:pub.10.1007/s10162-016-0569-5
8 sg:pub.10.1007/s10162-018-00693-0
9 sg:pub.10.1038/417543a
10 https://doi.org/10.1002/(sici)1096-9861(19991004)412:4<543::aid-cne1>3.0.co;2-3
11 https://doi.org/10.1002/ar.1092310411
12 https://doi.org/10.1002/cne.20888
13 https://doi.org/10.1002/cne.21886
14 https://doi.org/10.1002/cne.22262
15 https://doi.org/10.1002/cne.22339
16 https://doi.org/10.1002/cne.23038
17 https://doi.org/10.1016/0006-8993(74)90521-6
18 https://doi.org/10.1016/0014-4886(69)90010-7
19 https://doi.org/10.1016/0168-0102(94)90043-4
20 https://doi.org/10.1016/0378-5955(90)90030-s
21 https://doi.org/10.1016/0378-5955(91)90120-x
22 https://doi.org/10.1016/0378-5955(92)90172-j
23 https://doi.org/10.1016/j.heares.2008.06.005
24 https://doi.org/10.1016/j.heares.2011.01.019
25 https://doi.org/10.1016/j.heares.2014.08.005
26 https://doi.org/10.1016/j.heares.2014.10.004
27 https://doi.org/10.1016/j.heares.2018.01.014
28 https://doi.org/10.1016/j.jneumeth.2008.01.023
29 https://doi.org/10.1016/j.jneumeth.2010.05.014
30 https://doi.org/10.1016/j.jneumeth.2011.01.001
31 https://doi.org/10.1016/j.neuron.2015.12.041
32 https://doi.org/10.1016/s0006-8993(02)02235-7
33 https://doi.org/10.1016/s0378-5955(02)00644-5
34 https://doi.org/10.1016/s0378-5955(97)00046-4
35 https://doi.org/10.1016/s0378-5955(98)00209-3
36 https://doi.org/10.1016/s0378-5955(99)00171-9
37 https://doi.org/10.1037/h0035203
38 https://doi.org/10.1093/cercor/bhp222
39 https://doi.org/10.1097/aud.0b013e31806dc21a
40 https://doi.org/10.1111/j.1460-9568.2006.04982.x
41 https://doi.org/10.1113/jphysiol.2004.067421
42 https://doi.org/10.1121/1.3068457
43 https://doi.org/10.1121/1.3257546
44 https://doi.org/10.1121/1.395554
45 https://doi.org/10.1121/1.396664
46 https://doi.org/10.1121/1.405554
47 https://doi.org/10.1126/science.1119419
48 https://doi.org/10.1152/jn.00269.2012
49 https://doi.org/10.1152/jn.00303.2012
50 https://doi.org/10.1152/jn.00392.2016
51 https://doi.org/10.1152/jn.00731.2010
52 https://doi.org/10.1152/jn.00900.2004
53 https://doi.org/10.1152/jn.1987.57.5.1338
54 https://doi.org/10.1152/jn.1989.61.2.269
55 https://doi.org/10.1152/jn.1995.73.2.449
56 https://doi.org/10.1152/jn.1999.82.3.1363
57 https://doi.org/10.1152/jn.1999.82.6.2883
58 https://doi.org/10.1371/journal.pone.0048739
59 https://doi.org/10.1523/jneurosci.0052-07.2007
60 https://doi.org/10.1523/jneurosci.0762-04.2004
61 https://doi.org/10.1523/jneurosci.1699-16.2016
62 https://doi.org/10.1523/jneurosci.20-04-01605.2000
63 https://doi.org/10.1523/jneurosci.2084-13.2014
64 https://doi.org/10.1523/jneurosci.23-02-00716.2003
65 https://doi.org/10.1523/jneurosci.3213-10.2010
66 https://doi.org/10.1523/jneurosci.3328-17.2018
67 https://doi.org/10.1523/jneurosci.3795-15.2016
68 https://doi.org/10.1523/jneurosci.5517-09.2010
69 https://doi.org/10.2217/fnl.09.5
70 https://doi.org/10.3389/fnins.2016.00077
71 https://doi.org/10.7554/elife.21452
72 schema:datePublished 2019-02
73 schema:datePublishedReg 2019-02-01
74 schema:description Users of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Here, we characterized temporal coding and ITD sensitivity of single neurons in a novel animal model of early-onset deafness. Rabbits were deafened as neonates and deprived of auditory stimulation until they reached adult age when single-unit recordings from the auditory midbrain were made chronically using an unanesthetized preparation. The results are compared to measurements from adult-deafened rabbits with normal auditory development to understand the effect of early-onset deafness on neural temporal coding and ITD sensitivity. Neurons in the inferior colliculus (IC) of early-deafened rabbits were less likely to show sustained, excitatory responses to pulse train stimulation and more likely to show suppressive responses compared to neurons in adult-deaf animals. Fewer neurons showed synchronized responses to pulse trains at any rate in the early-deaf group. In addition, fewer neurons showed significant ITD sensitivity in their overall firing rate in the early-deaf group compared to adult-deaf animals. Neural ITD discrimination thresholds in the early-deaf group were poorer than thresholds in adult-deaf group, especially at high pulse rates. The overall degradation in neural ITD sensitivity is consistent with the difficulties encountered by human CI users with early-onset hearing loss. These results lay the groundwork for investigating whether the degradations in temporal coding and ITD sensitivity observed in early-deaf animals can be reversed by appropriate CI stimulation during development.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree false
78 schema:isPartOf N05f72d1515e348669916966f053e0c2f
79 Nddf05a442f424486bc21b8928e4cb825
80 sg:journal.1021546
81 schema:name Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness
82 schema:pagination 37-56
83 schema:productId N4eedea0c1ec045ad98589e1b4fd39714
84 N59933592968a49cab2788f32de77b68f
85 N60e82ddf223f4ec894fa38c3f1c3bcf9
86 Na270993dec6a4250bc8200a85cefdfbb
87 Nc3c644f5ca5f41e9a8f76c16a7e86e0c
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111258713
89 https://doi.org/10.1007/s10162-018-00708-w
90 schema:sdDatePublished 2019-04-11T10:30
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N90ddbe51c2c441ceb459a22aed0446a3
93 schema:url https://link.springer.com/10.1007%2Fs10162-018-00708-w
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N05f72d1515e348669916966f053e0c2f schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 N3336f73ce0a8409eb5da7c3693dae782 rdf:first sg:person.01341423720.94
100 rdf:rest Nefd4428b436348bfb1294bf5a5cf630f
101 N3e48ac71c33e496ebd2387e10365f246 schema:affiliation https://www.grid.ac/institutes/grid.39479.30
102 schema:familyName Wagner
103 schema:givenName Joseph D.
104 rdf:type schema:Person
105 N4eedea0c1ec045ad98589e1b4fd39714 schema:name readcube_id
106 schema:value 2defb248a8a1e31494979bc4df40878b276c6cec7ffca00673be582fd5799723
107 rdf:type schema:PropertyValue
108 N59933592968a49cab2788f32de77b68f schema:name dimensions_id
109 schema:value pub.1111258713
110 rdf:type schema:PropertyValue
111 N60e82ddf223f4ec894fa38c3f1c3bcf9 schema:name nlm_unique_id
112 schema:value 100892857
113 rdf:type schema:PropertyValue
114 N76b2120ae96d445db33b7690818ed2d1 rdf:first sg:person.01024267353.05
115 rdf:rest N3336f73ce0a8409eb5da7c3693dae782
116 N90ddbe51c2c441ceb459a22aed0446a3 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 Na270993dec6a4250bc8200a85cefdfbb schema:name doi
119 schema:value 10.1007/s10162-018-00708-w
120 rdf:type schema:PropertyValue
121 Naa8cbacf310743e0b6e118229d64f99f rdf:first sg:person.01232533151.18
122 rdf:rest N76b2120ae96d445db33b7690818ed2d1
123 Nc3c644f5ca5f41e9a8f76c16a7e86e0c schema:name pubmed_id
124 schema:value 30623319
125 rdf:type schema:PropertyValue
126 Nddf05a442f424486bc21b8928e4cb825 schema:volumeNumber 20
127 rdf:type schema:PublicationVolume
128 Nefd4428b436348bfb1294bf5a5cf630f rdf:first N3e48ac71c33e496ebd2387e10365f246
129 rdf:rest Nfcd6bd94815a456bae0014e5c9493f1a
130 Nfcd6bd94815a456bae0014e5c9493f1a rdf:first sg:person.01035744777.59
131 rdf:rest rdf:nil
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
136 schema:name Neurosciences
137 rdf:type schema:DefinedTerm
138 sg:grant.2438937 http://pending.schema.org/fundedItem sg:pub.10.1007/s10162-018-00708-w
139 rdf:type schema:MonetaryGrant
140 sg:grant.2488660 http://pending.schema.org/fundedItem sg:pub.10.1007/s10162-018-00708-w
141 rdf:type schema:MonetaryGrant
142 sg:grant.2682961 http://pending.schema.org/fundedItem sg:pub.10.1007/s10162-018-00708-w
143 rdf:type schema:MonetaryGrant
144 sg:grant.4241821 http://pending.schema.org/fundedItem sg:pub.10.1007/s10162-018-00708-w
145 rdf:type schema:MonetaryGrant
146 sg:journal.1021546 schema:issn 1438-7573
147 1525-3961
148 schema:name Journal of the Association for Research in Otolaryngology
149 rdf:type schema:Periodical
150 sg:person.01024267353.05 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
151 schema:familyName Buechel
152 schema:givenName Brian D.
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024267353.05
154 rdf:type schema:Person
155 sg:person.01035744777.59 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
156 schema:familyName Delgutte
157 schema:givenName Bertrand
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035744777.59
159 rdf:type schema:Person
160 sg:person.01232533151.18 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
161 schema:familyName Chung
162 schema:givenName Yoojin
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232533151.18
164 rdf:type schema:Person
165 sg:person.01341423720.94 schema:affiliation https://www.grid.ac/institutes/grid.411653.4
166 schema:familyName Sunwoo
167 schema:givenName Woongsang
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341423720.94
169 rdf:type schema:Person
170 sg:pub.10.1007/s00221-003-1619-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040067770
171 https://doi.org/10.1007/s00221-003-1619-x
172 rdf:type schema:CreativeWork
173 sg:pub.10.1007/s10162-013-0380-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027342908
174 https://doi.org/10.1007/s10162-013-0380-5
175 rdf:type schema:CreativeWork
176 sg:pub.10.1007/s10162-015-0527-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021016552
177 https://doi.org/10.1007/s10162-015-0527-7
178 rdf:type schema:CreativeWork
179 sg:pub.10.1007/s10162-016-0569-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015296753
180 https://doi.org/10.1007/s10162-016-0569-5
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/s10162-018-00693-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106809798
183 https://doi.org/10.1007/s10162-018-00693-0
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/417543a schema:sameAs https://app.dimensions.ai/details/publication/pub.1010760754
186 https://doi.org/10.1038/417543a
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1002/(sici)1096-9861(19991004)412:4<543::aid-cne1>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029039678
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/ar.1092310411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043010531
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/cne.20888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003717556
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/cne.21886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010522106
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/cne.22262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021834445
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/cne.22339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048360709
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/cne.23038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003780199
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0006-8993(74)90521-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030559232
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/0014-4886(69)90010-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034313821
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0168-0102(94)90043-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045551896
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0378-5955(90)90030-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1053618165
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0378-5955(91)90120-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009715707
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0378-5955(92)90172-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1044963902
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.heares.2008.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023877984
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.heares.2011.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017539243
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.heares.2014.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038063487
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.heares.2014.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038782763
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.heares.2018.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101044346
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.jneumeth.2008.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043587052
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.jneumeth.2010.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046909772
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.jneumeth.2011.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009400046
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.neuron.2015.12.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016157790
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0006-8993(02)02235-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025931228
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0378-5955(02)00644-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016409138
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0378-5955(97)00046-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029876209
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0378-5955(98)00209-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008806838
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0378-5955(99)00171-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019715836
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1037/h0035203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028457988
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/cercor/bhp222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037969329
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/aud.0b013e31806dc21a schema:sameAs https://app.dimensions.ai/details/publication/pub.1040782176
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1460-9568.2006.04982.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007461381
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1113/jphysiol.2004.067421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044488886
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1121/1.3068457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062320903
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1121/1.3257546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062322747
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1121/1.395554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062346846
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1121/1.396664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062347956
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1121/1.405554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062356843
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/science.1119419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062452714
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1152/jn.00269.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031364373
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1152/jn.00303.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049167581
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1152/jn.00392.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063199748
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1152/jn.00731.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009455654
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1152/jn.00900.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041627503
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1152/jn.1987.57.5.1338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079835763
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1152/jn.1989.61.2.269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079453828
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1152/jn.1995.73.2.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082496255
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1152/jn.1999.82.3.1363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074519570
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1152/jn.1999.82.6.2883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074564069
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1371/journal.pone.0048739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018844305
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1523/jneurosci.0052-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028057487
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1523/jneurosci.0762-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008026407
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1523/jneurosci.1699-16.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067642958
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1523/jneurosci.20-04-01605.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074586884
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1523/jneurosci.2084-13.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021409973
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1523/jneurosci.23-02-00716.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075219790
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1523/jneurosci.3213-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037008023
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1523/jneurosci.3328-17.2018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105227964
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1523/jneurosci.3795-15.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067643241
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1523/jneurosci.5517-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043484981
305 rdf:type schema:CreativeWork
306 https://doi.org/10.2217/fnl.09.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030432785
307 rdf:type schema:CreativeWork
308 https://doi.org/10.3389/fnins.2016.00077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006058756
309 rdf:type schema:CreativeWork
310 https://doi.org/10.7554/elife.21452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084484845
311 rdf:type schema:CreativeWork
312 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
313 schema:name Department of Otolaryngology, Harvard Medical School, 02115, Boston, MA, USA
314 Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA
315 Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, 02115, Boston, MA, USA
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.39479.30 schema:alternateName Massachusetts Eye and Ear Infirmary
318 schema:name Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.411653.4 schema:alternateName Gachon University Gil Medical Center
321 schema:name Department of Otolaryngology, Gachon University Gil Medical Center, 405-760, Incheon, South Korea
322 Department of Otolaryngology, Harvard Medical School, 02115, Boston, MA, USA
323 Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 02114, Boston, MA, USA
324 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...