Effect of Pulse Rate and Polarity on the Sensitivity of Auditory Brainstem and Cochlear Implant Users to Electrical Stimulation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

Robert P. Carlyon, John M. Deeks, Colette M. McKay

ABSTRACT

To further understand the response of the human brainstem to electrical stimulation, a series of experiments compared the effect of pulse rate and polarity on detection thresholds between auditory brainstem implant (ABI) and cochlear implant (CI) patients. Experiment 1 showed that for 400-ms pulse trains, ABI users' thresholds dropped by about 2 dB as pulse rate was increased from 71 to 500 pps, but only by an average of 0.6 dB as rate was increased further to 3500 pps. This latter decrease was much smaller than the 7.7-dB observed for CI users. A similar result was obtained for pulse trains with a 40-ms duration. Furthermore, experiment 2 showed that the threshold difference between 500- and 3500-pps pulse trains remained much smaller for ABI than for CI users, even for durations as short as 2 ms, indicating the effect of a fast-acting mechanism. Experiment 3 showed that ABI users' thresholds were lower for alternating-polarity than for fixed-polarity pulse trains, and that this difference was greater at 3500 pps than at 500 pps, consistent with the effect of pulse rate on ABI users' thresholds being influenced by charge interactions between successive biphasic pulses. Experiment 4 compared thresholds and loudness between trains of asymmetric pulses of opposite polarity, in monopolar mode, and showed that in both cases less current was needed when the anodic, rather than the cathodic, current was concentrated into a short time interval. This finding is similar to that previously observed for CI users and is consistent with ABI users being more sensitive to anodic than cathodic current. We argue that our results constrain potential explanations for the differences in the perception of electrical stimulation by CI and ABI users, and have potential implications for future ABI stimulation strategies. More... »

PAGES

653-668

References to SciGraph publications

  • 2013-06. The Polarity Sensitivity of the Electrically Stimulated Human Auditory Nerve Measured at the Level of the Brainstem in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • 2013-02. Temporal Processing in the Auditory System in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • 2008-06. Higher Sensitivity of Human Auditory Nerve Fibers to Positive Electrical Currents in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • 2007-09. Changes Across Time in Spike Rate and Spike Amplitude of Auditory Nerve Fibers Stimulated by Electric Pulse Trains in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • 2011-04. Extending the Limits of Place and Temporal Pitch Perception in Cochlear Implant Users in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • 2006-09. Asymmetric Pulses in Cochlear Implants: Effects of Pulse Shape, Polarity, and Rate in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10162-015-0530-z

    DOI

    http://dx.doi.org/10.1007/s10162-015-0530-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007682117

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26138501


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Auditory Brain Stem Implants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Auditory Threshold", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cochlear Implants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Electric Stimulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Loudness Perception", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "MRC Cognition and Brain Sciences Unit", 
              "id": "https://www.grid.ac/institutes/grid.415036.5", 
              "name": [
                "MRC Cognition & Brain Sciences Unit, 15 Chaucer Rd., Cambridge, England"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carlyon", 
            "givenName": "Robert P.", 
            "id": "sg:person.01272240240.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272240240.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "MRC Cognition and Brain Sciences Unit", 
              "id": "https://www.grid.ac/institutes/grid.415036.5", 
              "name": [
                "MRC Cognition & Brain Sciences Unit, 15 Chaucer Rd., Cambridge, England"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deeks", 
            "givenName": "John M.", 
            "id": "sg:person.01115267203.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115267203.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bionics Institute", 
              "id": "https://www.grid.ac/institutes/grid.431365.6", 
              "name": [
                "Audiology & Deafness Research Group, School of Psychological Sciences, University of Manchester, M13 9PL, Manchester, England", 
                "The Bionics Institute of Australia, 384 Albert St, 3002, East Melbourne, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McKay", 
            "givenName": "Colette M.", 
            "id": "sg:person.0754245034.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754245034.16"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0378-5955(92)90024-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001239212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-5955(92)90024-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001239212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-008-0112-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002641638", 
              "https://doi.org/10.1007/s10162-008-0112-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-008-0112-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002641638", 
              "https://doi.org/10.1007/s10162-008-0112-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/aud.0000000000000146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002767792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/aud.0000000000000146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002767792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.heares.2006.02.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003181356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-010-0248-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004832465", 
              "https://doi.org/10.1007/s10162-010-0248-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-010-0248-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004832465", 
              "https://doi.org/10.1007/s10162-010-0248-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2008.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006057007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-012-0354-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011131444", 
              "https://doi.org/10.1007/s10162-012-0354-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moo.0b013e328357613d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013291451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moo.0b013e328357613d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013291451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-006-0040-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015911698", 
              "https://doi.org/10.1007/s10162-006-0040-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-007-0086-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020443388", 
              "https://doi.org/10.1007/s10162-007-0086-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-007-0086-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020443388", 
              "https://doi.org/10.1007/s10162-007-0086-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mlg.0000178327.42926.ec", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024862472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mlg.0000178327.42926.ec", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024862472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mlg.0000178327.42926.ec", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024862472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.heares.2010.06.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034763625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-5955(90)90173-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036109000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-5955(90)90173-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036109000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-5955(85)90005-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036836874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-5955(85)90005-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036836874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003446-200506000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042666163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003446-200506000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042666163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003446-200506000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042666163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-013-0377-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049810852", 
              "https://doi.org/10.1007/s10162-013-0377-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/aud.0000000000000048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052669581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/aud.0000000000000048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052669581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/51.395310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061184603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1121/1.1760795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062270240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1121/1.3257231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062322743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1121/1.399185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062350477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1121/1.423316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062374580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1121/1.4807900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062400194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8160013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/2013.9.jns12686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071079205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/2013.9.jns12686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071079205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/2013.9.jns12686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071079205"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-10", 
        "datePublishedReg": "2015-10-01", 
        "description": "To further understand the response of the human brainstem to electrical stimulation, a series of experiments compared the effect of pulse rate and polarity on detection thresholds between auditory brainstem implant (ABI) and cochlear implant (CI) patients. Experiment 1 showed that for 400-ms pulse trains, ABI users' thresholds dropped by about 2 dB as pulse rate was increased from 71 to 500 pps, but only by an average of 0.6 dB as rate was increased further to 3500 pps. This latter decrease was much smaller than the 7.7-dB observed for CI users. A similar result was obtained for pulse trains with a 40-ms duration. Furthermore, experiment 2 showed that the threshold difference between 500- and 3500-pps pulse trains remained much smaller for ABI than for CI users, even for durations as short as 2 ms, indicating the effect of a fast-acting mechanism. Experiment 3 showed that ABI users' thresholds were lower for alternating-polarity than for fixed-polarity pulse trains, and that this difference was greater at 3500 pps than at 500 pps, consistent with the effect of pulse rate on ABI users' thresholds being influenced by charge interactions between successive biphasic pulses. Experiment 4 compared thresholds and loudness between trains of asymmetric pulses of opposite polarity, in monopolar mode, and showed that in both cases less current was needed when the anodic, rather than the cathodic, current was concentrated into a short time interval. This finding is similar to that previously observed for CI users and is consistent with ABI users being more sensitive to anodic than cathodic current. We argue that our results constrain potential explanations for the differences in the perception of electrical stimulation by CI and ABI users, and have potential implications for future ABI stimulation strategies. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10162-015-0530-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2751479", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1021546", 
            "issn": [
              "1525-3961", 
              "1438-7573"
            ], 
            "name": "Journal of the Association for Research in Otolaryngology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "Effect of Pulse Rate and Polarity on the Sensitivity of Auditory Brainstem and Cochlear Implant Users to Electrical Stimulation", 
        "pagination": "653-668", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2497b778ff9237c17cdae0b1c66b6ba4f299d2133564573b66a40800161ad4b1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26138501"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100892857"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10162-015-0530-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007682117"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10162-015-0530-z", 
          "https://app.dimensions.ai/details/publication/pub.1007682117"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:10", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88247_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs10162-015-0530-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10162-015-0530-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10162-015-0530-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10162-015-0530-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10162-015-0530-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    214 TRIPLES      21 PREDICATES      65 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10162-015-0530-z schema:about N1648739ca0014d1f852a726b4609010a
    2 N57807e9b4fd846cd89fc41d6b9340f33
    3 N76f8b14c05924eb997b67bc52594ca14
    4 N9babf035ab42461eb2931fd234e40f83
    5 N9fe3185d9d114f2d8a00ee3d4f6fd25c
    6 Na4811f3d43d7432ab1e4df18b682523d
    7 Nb9d8a99e949149a1b5cfbfee7f6ff8c1
    8 Nc4ce29f65001492b8558b09a42e341cd
    9 Ne9e7216a7d0e4b33931c9bd61c06aff6
    10 Nec0420f0017b4c5db852abf3205bc2bc
    11 Nf257e54b38f84e21b7db1961beee570a
    12 anzsrc-for:11
    13 anzsrc-for:1109
    14 schema:author Nea1a02074ca34c30860344cfe47f215f
    15 schema:citation sg:pub.10.1007/s10162-006-0040-0
    16 sg:pub.10.1007/s10162-007-0086-7
    17 sg:pub.10.1007/s10162-008-0112-4
    18 sg:pub.10.1007/s10162-010-0248-x
    19 sg:pub.10.1007/s10162-012-0354-z
    20 sg:pub.10.1007/s10162-013-0377-0
    21 https://doi.org/10.1016/0378-5955(85)90005-x
    22 https://doi.org/10.1016/0378-5955(90)90173-m
    23 https://doi.org/10.1016/0378-5955(92)90024-h
    24 https://doi.org/10.1016/j.heares.2006.02.012
    25 https://doi.org/10.1016/j.heares.2010.06.017
    26 https://doi.org/10.1016/j.neuroscience.2008.02.041
    27 https://doi.org/10.1097/00003446-200506000-00002
    28 https://doi.org/10.1097/01.mlg.0000178327.42926.ec
    29 https://doi.org/10.1097/aud.0000000000000048
    30 https://doi.org/10.1097/aud.0000000000000146
    31 https://doi.org/10.1097/moo.0b013e328357613d
    32 https://doi.org/10.1109/51.395310
    33 https://doi.org/10.1121/1.1760795
    34 https://doi.org/10.1121/1.3257231
    35 https://doi.org/10.1121/1.399185
    36 https://doi.org/10.1121/1.423316
    37 https://doi.org/10.1121/1.4807900
    38 https://doi.org/10.1126/science.8160013
    39 https://doi.org/10.3171/2013.9.jns12686
    40 schema:datePublished 2015-10
    41 schema:datePublishedReg 2015-10-01
    42 schema:description To further understand the response of the human brainstem to electrical stimulation, a series of experiments compared the effect of pulse rate and polarity on detection thresholds between auditory brainstem implant (ABI) and cochlear implant (CI) patients. Experiment 1 showed that for 400-ms pulse trains, ABI users' thresholds dropped by about 2 dB as pulse rate was increased from 71 to 500 pps, but only by an average of 0.6 dB as rate was increased further to 3500 pps. This latter decrease was much smaller than the 7.7-dB observed for CI users. A similar result was obtained for pulse trains with a 40-ms duration. Furthermore, experiment 2 showed that the threshold difference between 500- and 3500-pps pulse trains remained much smaller for ABI than for CI users, even for durations as short as 2 ms, indicating the effect of a fast-acting mechanism. Experiment 3 showed that ABI users' thresholds were lower for alternating-polarity than for fixed-polarity pulse trains, and that this difference was greater at 3500 pps than at 500 pps, consistent with the effect of pulse rate on ABI users' thresholds being influenced by charge interactions between successive biphasic pulses. Experiment 4 compared thresholds and loudness between trains of asymmetric pulses of opposite polarity, in monopolar mode, and showed that in both cases less current was needed when the anodic, rather than the cathodic, current was concentrated into a short time interval. This finding is similar to that previously observed for CI users and is consistent with ABI users being more sensitive to anodic than cathodic current. We argue that our results constrain potential explanations for the differences in the perception of electrical stimulation by CI and ABI users, and have potential implications for future ABI stimulation strategies.
    43 schema:genre research_article
    44 schema:inLanguage en
    45 schema:isAccessibleForFree true
    46 schema:isPartOf Ne61ff00257574f3690f7216d7d867366
    47 Nf79a40c4179a4861a377ded94339d70c
    48 sg:journal.1021546
    49 schema:name Effect of Pulse Rate and Polarity on the Sensitivity of Auditory Brainstem and Cochlear Implant Users to Electrical Stimulation
    50 schema:pagination 653-668
    51 schema:productId N169cefd842a246048093d3e2bc9d681e
    52 N3b2ce55f655343459bdd34c5dc882284
    53 N7cc4526356494322a2245e5a7fb08a8c
    54 Nda2d590b6eed447697aeae306207b455
    55 Ndb069f894c2b4c289967f781f8ea500f
    56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007682117
    57 https://doi.org/10.1007/s10162-015-0530-z
    58 schema:sdDatePublished 2019-04-11T13:10
    59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    60 schema:sdPublisher Nfa87cc8286974f88ab8d7b59a72a592d
    61 schema:url http://link.springer.com/10.1007%2Fs10162-015-0530-z
    62 sgo:license sg:explorer/license/
    63 sgo:sdDataset articles
    64 rdf:type schema:ScholarlyArticle
    65 N1648739ca0014d1f852a726b4609010a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    66 schema:name Humans
    67 rdf:type schema:DefinedTerm
    68 N169cefd842a246048093d3e2bc9d681e schema:name doi
    69 schema:value 10.1007/s10162-015-0530-z
    70 rdf:type schema:PropertyValue
    71 N3b2ce55f655343459bdd34c5dc882284 schema:name dimensions_id
    72 schema:value pub.1007682117
    73 rdf:type schema:PropertyValue
    74 N4217bbb49877473ca09d207645cdc984 rdf:first sg:person.01115267203.81
    75 rdf:rest Nbb0b5c034cff4f0a8f69bbbad4a1644e
    76 N57807e9b4fd846cd89fc41d6b9340f33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Auditory Threshold
    78 rdf:type schema:DefinedTerm
    79 N76f8b14c05924eb997b67bc52594ca14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Heart Rate
    81 rdf:type schema:DefinedTerm
    82 N7cc4526356494322a2245e5a7fb08a8c schema:name nlm_unique_id
    83 schema:value 100892857
    84 rdf:type schema:PropertyValue
    85 N9babf035ab42461eb2931fd234e40f83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Loudness Perception
    87 rdf:type schema:DefinedTerm
    88 N9fe3185d9d114f2d8a00ee3d4f6fd25c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Aged, 80 and over
    90 rdf:type schema:DefinedTerm
    91 Na4811f3d43d7432ab1e4df18b682523d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Auditory Brain Stem Implants
    93 rdf:type schema:DefinedTerm
    94 Nb9d8a99e949149a1b5cfbfee7f6ff8c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Electric Stimulation
    96 rdf:type schema:DefinedTerm
    97 Nbb0b5c034cff4f0a8f69bbbad4a1644e rdf:first sg:person.0754245034.16
    98 rdf:rest rdf:nil
    99 Nc4ce29f65001492b8558b09a42e341cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Middle Aged
    101 rdf:type schema:DefinedTerm
    102 Nda2d590b6eed447697aeae306207b455 schema:name readcube_id
    103 schema:value 2497b778ff9237c17cdae0b1c66b6ba4f299d2133564573b66a40800161ad4b1
    104 rdf:type schema:PropertyValue
    105 Ndb069f894c2b4c289967f781f8ea500f schema:name pubmed_id
    106 schema:value 26138501
    107 rdf:type schema:PropertyValue
    108 Ne61ff00257574f3690f7216d7d867366 schema:volumeNumber 16
    109 rdf:type schema:PublicationVolume
    110 Ne9e7216a7d0e4b33931c9bd61c06aff6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Aged
    112 rdf:type schema:DefinedTerm
    113 Nea1a02074ca34c30860344cfe47f215f rdf:first sg:person.01272240240.40
    114 rdf:rest N4217bbb49877473ca09d207645cdc984
    115 Nec0420f0017b4c5db852abf3205bc2bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Cochlear Implants
    117 rdf:type schema:DefinedTerm
    118 Nf257e54b38f84e21b7db1961beee570a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Adult
    120 rdf:type schema:DefinedTerm
    121 Nf79a40c4179a4861a377ded94339d70c schema:issueNumber 5
    122 rdf:type schema:PublicationIssue
    123 Nfa87cc8286974f88ab8d7b59a72a592d schema:name Springer Nature - SN SciGraph project
    124 rdf:type schema:Organization
    125 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    126 schema:name Medical and Health Sciences
    127 rdf:type schema:DefinedTerm
    128 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    129 schema:name Neurosciences
    130 rdf:type schema:DefinedTerm
    131 sg:grant.2751479 http://pending.schema.org/fundedItem sg:pub.10.1007/s10162-015-0530-z
    132 rdf:type schema:MonetaryGrant
    133 sg:journal.1021546 schema:issn 1438-7573
    134 1525-3961
    135 schema:name Journal of the Association for Research in Otolaryngology
    136 rdf:type schema:Periodical
    137 sg:person.01115267203.81 schema:affiliation https://www.grid.ac/institutes/grid.415036.5
    138 schema:familyName Deeks
    139 schema:givenName John M.
    140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115267203.81
    141 rdf:type schema:Person
    142 sg:person.01272240240.40 schema:affiliation https://www.grid.ac/institutes/grid.415036.5
    143 schema:familyName Carlyon
    144 schema:givenName Robert P.
    145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272240240.40
    146 rdf:type schema:Person
    147 sg:person.0754245034.16 schema:affiliation https://www.grid.ac/institutes/grid.431365.6
    148 schema:familyName McKay
    149 schema:givenName Colette M.
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754245034.16
    151 rdf:type schema:Person
    152 sg:pub.10.1007/s10162-006-0040-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015911698
    153 https://doi.org/10.1007/s10162-006-0040-0
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1007/s10162-007-0086-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020443388
    156 https://doi.org/10.1007/s10162-007-0086-7
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1007/s10162-008-0112-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002641638
    159 https://doi.org/10.1007/s10162-008-0112-4
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1007/s10162-010-0248-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004832465
    162 https://doi.org/10.1007/s10162-010-0248-x
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s10162-012-0354-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1011131444
    165 https://doi.org/10.1007/s10162-012-0354-z
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/s10162-013-0377-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049810852
    168 https://doi.org/10.1007/s10162-013-0377-0
    169 rdf:type schema:CreativeWork
    170 https://doi.org/10.1016/0378-5955(85)90005-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036836874
    171 rdf:type schema:CreativeWork
    172 https://doi.org/10.1016/0378-5955(90)90173-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1036109000
    173 rdf:type schema:CreativeWork
    174 https://doi.org/10.1016/0378-5955(92)90024-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1001239212
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1016/j.heares.2006.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003181356
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1016/j.heares.2010.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034763625
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1016/j.neuroscience.2008.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006057007
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1097/00003446-200506000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042666163
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1097/01.mlg.0000178327.42926.ec schema:sameAs https://app.dimensions.ai/details/publication/pub.1024862472
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1097/aud.0000000000000048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052669581
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1097/aud.0000000000000146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002767792
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1097/moo.0b013e328357613d schema:sameAs https://app.dimensions.ai/details/publication/pub.1013291451
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1109/51.395310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061184603
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1121/1.1760795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062270240
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1121/1.3257231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062322743
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1121/1.399185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062350477
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1121/1.423316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062374580
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1121/1.4807900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062400194
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1126/science.8160013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652982
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.3171/2013.9.jns12686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071079205
    207 rdf:type schema:CreativeWork
    208 https://www.grid.ac/institutes/grid.415036.5 schema:alternateName MRC Cognition and Brain Sciences Unit
    209 schema:name MRC Cognition & Brain Sciences Unit, 15 Chaucer Rd., Cambridge, England
    210 rdf:type schema:Organization
    211 https://www.grid.ac/institutes/grid.431365.6 schema:alternateName Bionics Institute
    212 schema:name Audiology & Deafness Research Group, School of Psychological Sciences, University of Manchester, M13 9PL, Manchester, England
    213 The Bionics Institute of Australia, 384 Albert St, 3002, East Melbourne, Australia
    214 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...