Evaluation of a newly proposed renal risk score for Japanese patients with ANCA-associated glomerulonephritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-04-08

AUTHORS

Masaya Saito, Ayano Saito, Fumito Abe, Chihiro Imaizumi, Hajime Kaga, Masato Sawamura, Mizuho Nara, Masatoyo Ozawa, Ryuta Sato, Takahiro Nakayama, Shin Okuyama, Rie Masai, Hiroshi Ohtani, Atsushi Komatsuda, Hideki Wakui, Naoto Takahashi

ABSTRACT

BackgroundWe determined the usefulness and prognostic ability of the renal risk score (RRS), proposed in Europe, for Japanese patients with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) and high myeloperoxidase (MPO)-ANCA positivity; these aspects remain to be verified.MethodsThis retrospective study was conducted on 86 Japanese patients with new, biopsy-confirmed AAGN. We calculated the RRS and analyzed the relationship between this classification, and clinicopathological features and prognosis. We also compared the predictive values between RRS for endpoints including renal death and conventional prognostic tools for patients with AAGN.ResultsThere were 33, 37, and 16 patients in the low-, medium-, and high-risk groups, respectively. All patients were MPO-ANCA positive. The median follow-up period was 33 months; 16 (18.6%) patients progressed to end-stage renal disease (ESRD). In the high-risk group, 9/16 (56.3%) patients progressed to ESRD, and renal prognosis was significantly poorer than that in other groups (low-risk group, P < 0.001; medium-risk group, P = 0.004). In Cox multivariate regression analysis, RRS was an independent, poor renal prognostic factor (hazard ratio 5.22; 95% confidence interval 2.20–12.40; P < 0.001). The receiver-operating characteristic curves of the RRS for each endpoint were comparable with those of the 2010 histological classification and those of the severity classification of Japanese rapidly progressive glomerulonephritis.ConclusionsThis is the first study to report the usefulness of the RRS for predicting renal outcomes among Japanese patients with AAGN. Our predictive value of the RRS was comparable with that of conventional prognostic tools. More... »

PAGES

760-769

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-022-02217-w

DOI

http://dx.doi.org/10.1007/s10157-022-02217-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146961360

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35394553


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21 schema:description BackgroundWe determined the usefulness and prognostic ability of the renal risk score (RRS), proposed in Europe, for Japanese patients with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) and high myeloperoxidase (MPO)-ANCA positivity; these aspects remain to be verified.MethodsThis retrospective study was conducted on 86 Japanese patients with new, biopsy-confirmed AAGN. We calculated the RRS and analyzed the relationship between this classification, and clinicopathological features and prognosis. We also compared the predictive values between RRS for endpoints including renal death and conventional prognostic tools for patients with AAGN.ResultsThere were 33, 37, and 16 patients in the low-, medium-, and high-risk groups, respectively. All patients were MPO-ANCA positive. The median follow-up period was 33 months; 16 (18.6%) patients progressed to end-stage renal disease (ESRD). In the high-risk group, 9/16 (56.3%) patients progressed to ESRD, and renal prognosis was significantly poorer than that in other groups (low-risk group, P < 0.001; medium-risk group, P = 0.004). In Cox multivariate regression analysis, RRS was an independent, poor renal prognostic factor (hazard ratio 5.22; 95% confidence interval 2.20–12.40; P < 0.001). The receiver-operating characteristic curves of the RRS for each endpoint were comparable with those of the 2010 histological classification and those of the severity classification of Japanese rapidly progressive glomerulonephritis.ConclusionsThis is the first study to report the usefulness of the RRS for predicting renal outcomes among Japanese patients with AAGN. Our predictive value of the RRS was comparable with that of conventional prognostic tools.
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27 schema:keywords AAGN
28 ANCA
29 ANCA positivity
30 BackgroundWe
31 ConclusionsThis
32 Cox multivariate regression analysis
33 Europe
34 Japanese patients
35 MPO-ANCA
36 MethodsThis retrospective study
37 ResultsThere
38 ability
39 analysis
40 antibodies
41 antineutrophil cytoplasmic antibody
42 aspects
43 characteristic curve
44 classification
45 clinicopathological features
46 curves
47 cytoplasmic antibodies
48 death
49 disease
50 end-stage renal disease
51 endpoint
52 evaluation
53 factors
54 features
55 first study
56 follow
57 glomerulonephritis
58 group
59 high-risk group
60 higher myeloperoxidase
61 histological classification
62 median follow
63 medium
64 months
65 multivariate regression analysis
66 myeloperoxidase
67 outcomes
68 patients
69 period
70 positivity
71 predictive value
72 prognosis
73 prognostic ability
74 prognostic factors
75 prognostic tool
76 receiver-operating characteristic curve
77 regression analysis
78 relationship
79 renal death
80 renal disease
81 renal outcomes
82 renal prognosis
83 renal risk score
84 retrospective study
85 risk score
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