Comparative proteomic analysis of renal proteins from IgA nephropathy model mice and control mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-05-20

AUTHORS

Rena Miyakawa, Akiko Sato, Yuka Matsuda, Ayano Saito, Fumito Abe, Hirotoshi Matsumura, Masafumi Odaka, Takehiro Suzuki, Naoshi Dohmae, Atsushi Komatsuda, Naoto Takahashi, Hideki Wakui

ABSTRACT

BackgroundHigh-IgA ddY (HIGA) mice, an animal model of human IgA nephropathy (IgAN), spontaneously develop nephropathy with glomerular IgA deposition and markedly elevated serum IgA levels from 25 weeks of age.MethodsWe performed a comparative proteomic analysis of the renal proteins collected from HIGA mice and control C57BL/6 mice at 5 or 38 weeks of age (the H5, H38, C5, and C38 groups) (n = 4 in each group). Proteins were extracted from the left whole kidney of each mouse and analyzed using nano-liquid chromatography–tandem mass spectrometry. The right kidneys were used for histopathological examinations.ResultsImmunohistochemical examinations showed glomerular deposition of IgA and the immunoglobulin joining (J) chain, and increased numbers of interstitial IgA- and J-chain-positive plasma cells in the H38 group. In the proteomic analysis, > 5000 proteins were identified, and 33 proteins with H38/H5 ratios of > 5.0, H38/C38 ratios of > 5.0, and C38/C5 ratios of < 1.5 were selected. Among them, there were various proteins that are known to be involved in human IgAN and/or animal IgAN models. Immunohistochemical examinations validated the proteomic results for some proteins. Furthermore, two proteins that are known to be associated with kidney disease displayed downregulated expression (H38/H5 ratio: 0.01) in the H38 group.ConclusionsThe results of comparative proteomic analysis of renal proteins were consistent with previous histopathological and serological findings obtained in ddY and HIGA mice. Various proteins that are known to be involved in kidney disease, including IgAN, and potential disease marker proteins exhibited markedly altered levels in HIGA mice. More... »

PAGES

666-679

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-020-01898-5

DOI

http://dx.doi.org/10.1007/s10157-020-01898-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1127758271

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32436031


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73 number
74 plasma cells
75 protein
76 proteomic analysis
77 proteomic results
78 ratio
79 renal proteins
80 results
81 right kidney
82 serological findings
83 serum IgA levels
84 spectrometry
85 weeks
86 weeks of age
87 whole kidney
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