Vasa recta hyalinosis reflects severe arteriolopathy in renal allografts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-08

AUTHORS

Hideyo Oguchi, Ken Sakai, Yutaka Yamaguchi, Tetuo Mikami, Tetsuo Nemoto, Yasushi Ohashi, Takeshi Kawamura, Masaki Muramatsu, Yoshihiro Itabashi, Kazunobu Shinoda, Yoji Hyodo, Yusuke Takahashi, Yuki Kawaguchi, Hiroka Onishi, Yuko Hamasaki, Kazutoshi Shibuya, Seiichiro Shishido

ABSTRACT

AimWe examined the clinicopathologic significance of hyalinosis in the vasa recta in the medulla of allograft kidney biopsies.MethodWe analyzed biopsy specimens from January 2010 to December 2015, obtained from both the cortex and medulla (including the vasa recta) ≥ 1 year after living-donor kidney transplantation. We excluded biopsy specimens from recipients who had undergone transplantation due to diabetic nephropathy or who had diabetes mellitus after transplantation. We evaluated hyaline arteriolopathy in the cortex using the aah score determined by the Banff 2007 classification.ResultAmong 381 biopsy specimens obtained from 248 transplant recipients ≥ 1 year after transplantation, 36 specimens obtained from 34 recipients showed vasa recta hyalinosis (VRH) in the medulla. Among these 36 specimens, 17 had a score of aah3, 16 had a score of aah2, and 3 had a score of aah1. The incidence of VRH was 1.9% at ≥ 1 to < 4 years, 7.1% at ≥ 4 to < 8 years, and 50.0% at ≥ 8 years. The aah scores and the proportion of hyalinosis in the arteriolar media among all muscular arterioles in the cortex were significantly higher in the VRH group at ≥ 8 years in the late-phase biopsy (P < 0.01). The graft survival was worse in the VRH group (P = 0.024), although there was no significant difference in the graft survival between the ≥ aah2 and < aah2 groups at ≥ 8 years in the late-phase biopsy (P = 0.159).ConclusionVRH in renal allografts reflects severe arteriolopathy of the cortex. VRH in the late-phase biopsy may be a prognostic factor for graft survival. More... »

PAGES

799-806

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-019-01709-6

DOI

http://dx.doi.org/10.1007/s10157-019-01709-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112024410

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30734165


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26 schema:description AimWe examined the clinicopathologic significance of hyalinosis in the vasa recta in the medulla of allograft kidney biopsies.MethodWe analyzed biopsy specimens from January 2010 to December 2015, obtained from both the cortex and medulla (including the vasa recta) ≥ 1 year after living-donor kidney transplantation. We excluded biopsy specimens from recipients who had undergone transplantation due to diabetic nephropathy or who had diabetes mellitus after transplantation. We evaluated hyaline arteriolopathy in the cortex using the aah score determined by the Banff 2007 classification.ResultAmong 381 biopsy specimens obtained from 248 transplant recipients ≥ 1 year after transplantation, 36 specimens obtained from 34 recipients showed vasa recta hyalinosis (VRH) in the medulla. Among these 36 specimens, 17 had a score of aah3, 16 had a score of aah2, and 3 had a score of aah1. The incidence of VRH was 1.9% at ≥ 1 to < 4 years, 7.1% at ≥ 4 to < 8 years, and 50.0% at ≥ 8 years. The aah scores and the proportion of hyalinosis in the arteriolar media among all muscular arterioles in the cortex were significantly higher in the VRH group at ≥ 8 years in the late-phase biopsy (P < 0.01). The graft survival was worse in the VRH group (P = 0.024), although there was no significant difference in the graft survival between the ≥ aah2 and < aah2 groups at ≥ 8 years in the late-phase biopsy (P = 0.159).ConclusionVRH in renal allografts reflects severe arteriolopathy of the cortex. VRH in the late-phase biopsy may be a prognostic factor for graft survival.
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32 schema:keywords AAH1
33 AAH2
34 AimWe
35 Banff 2007 classification
36 MethodWe
37 aah score
38 allograft kidney biopsy
39 allografts
40 arteriolar media
41 arterioles
42 arteriolopathy
43 biopsy
44 biopsy specimens
45 classification
46 clinicopathologic significance
47 cortex
48 diabetes mellitus
49 diabetic nephropathy
50 differences
51 factors
52 graft survival
53 group
54 hyalinosis
55 incidence
56 kidney biopsy
57 kidney transplantation
58 live donor kidney transplantation
59 medium
60 medulla
61 mellitus
62 muscular arterioles
63 nephropathy
64 prognostic factors
65 proportion
66 recipients
67 rectum
68 renal allografts
69 scores
70 significance
71 significant differences
72 specimens
73 survival
74 transplant recipients
75 transplantation
76 vasa recta
77 years
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